Doctor insights on:
Symptoms Of Nf1 And Nf2
Possible: NIH diagnostic criteria for NF1 with two or more of following features:1)6 or more café-au-lait macules over 5 mm in diameter prepubertal individuals over 15 mm in greatest diameter in postpubertal. 2) 2or more neurofibromas or one plexiform neurofibroma.3)Freckling in armpit or groin areas4)Optic glioma (optic nerve tumor)5) > 2 Lisch nodules (iris of eye)6)typical bone lesions 7)1deg relative nf1 ...Read more
Many manifestations: Commonly nf gradually appears with development of brown flat spots and soft nodules under the skin. The brown (café-au-lai) spots are the main symptom of neurofibromatosis. Freckling of armpits, neurofibromas orsubcutaneous bumps, which increase in number with age. Lisch nodules (hamartomas of iris), gliomas of the optic nerve, skeletal dysplasias with limb abnormalities and scoliosis. ...Read more
There are 2 froms.: Nf-1 is characterized by tumors on small nerves under the skin. The worst form of this was depicted in a movie called the "elephant man". Tumors on spinal nerves can cause numness and weakness of certain arm or leg muscles. Nf-2 is characterized by brain tumors. The most common form is a tumor on both hearing nerves. Hearing loss, dizzyness, and ringing in the ear are common symptoms of nf-2. ...Read more
Sometimes at birth: Several signs of nf, the main one six or more flat brown spots over 5 mm in greatest diameter in children and over 15 mm in greatest diameter in post-pubertal individuals, two or more soft nodules or neurofibromas or 1 plexiform neurofibroma, freckling in the axillary or groin regions, tumors of optic nerve, gliomas, bony abnormality such as scoliosis, bone overgrowth or congenital fracture. ...Read more
Puberty: Usually. But the rarer types can show up sooner. ...Read more
Many others: There are a number of criteria necessary to make the diagnosis of neurofibromatosis. A relative with the condition, neurofibromas (fleshy bumps), more than 5 brown patches (cafe au lait spots) > 1.5 cm in adults, freckling under the arms and groin, and eye changes (can be diagnosed by an ophthalmologist). There are also many different forms of the condition. ...Read more
NF 1 is caused by: Mutations of the NF gene, 17q11.2. Clinical course varies widely depending largely on location & size of brain, skin, eye & other tumors. Initial evaluations by a geneticist, ped. Neurologist, ped. Ophthalmologist, developmental/behavioral pediatrician. & Early Intervention, http://www. Dds. Ca.gov/EarlyStart/home. Cfm., guide management. Learning Disabilities & ADHD are common. See www. Ctf. Org. ...Read more
If lumps occur after 19 year and no other symptoms of neurofibromatosis found in early age. Which I seen in wikipidia? But it look like lipoma is it?
Need to see it.: You can have one neurofibroma without having neurofibromatosis, but it's more likely, statistically, to be a lipoma. A dermatologist can usually tell the difference just by looking, but a biopsy might be necessary to know for sure. Either way, see a dermatologist so you won't need to worry about it anymore. ...Read more
How I physically examine that my lumps are only lipomas not neurofibroma? I have only lumps no other symptoms of neurofibromatosis? My age is 27
Other signs with NF1:
Some helpful clues in distinguishing the 2:
café au lait macules--irregularly shaped, evenly pigmented, brown macules. Most have 6 or more café au lait spots that are 1.5 cm or greater in diameter.
Axillary and/or perineal freckling
neurofibromas nodules may be brown, pink, or skin colored, soft or firm to the touch, and they may have the pathognomonic buttonhole invagination when pressed on. ...Read more
Sir, I have no symptoms of neurofibromatosis and also not in my father and mom but some lumps are in my hand and very few on my thigh, is it lipoma?
Not reported: Chances of nf1 and nf2 occurring in same patient extremely rare. They are caused by different genes and chromosomes. Nf1 occurs in an estimated one out of every 3, 500 births. Approximately 50% inherited and other 50% of cases are the result of spontaneous genetic mutation. Severity varies with expression. Nf2 occurs in an estimated one out of every 40, 000 births. Smaller percentage inherited. ...Read more
I have two extremely light hyperpigmented areas that are about 2 cm and 1.5 cm each. And then two actual cafe au spots that are both less than 1cm. No other criteria at all. Nf1, nf2? Something else? Or just normal?
Just normal: You need 6 or more cafe au lait spots to make the diagnosis, other signs are Lisch nodules in the iris, optic gliomas in the brain, fibromas in skin and kidneys ...Read more
I have Neurofibromatosis NF1 and I'm struggling to gain weight I eat a lot more than normal people but still can't seem to gain any weight. I'm u/wigh?
Endocrinologist: Input is what you need, ask for a referral, best wishes ...Read more
Nerve ; brain tumors: Neurofibromatosis, inherited problem, with varying degrees of involvement from mild to severe. Neurofibroma is benign tumor that originates from the nerve cells. Tumors usually arise from nerves in the skin or jut under the skin. Type 1 usually appears in children with brown flat skin spots, freckling in armpits, and soft tumors under the skin and sometimes bone deformity. Type 2 usually brain tumors. ...Read more
Congenital condition: Neurofibromatosis is an autosomal dominant genetic disease, meaning if one of your parents has the disease you have a 50% chance of inheriting the disease. There are also instances of spontaneous mutation in about half of cases where an individual has the disease but it is not seen in family members. Either way, you are born with the condition, but may not see symptoms until later. ...Read more
Define rare: At 1/4000 births this is relatively common compared to many genetically influenced afflictions. About a 3rd are new mutations and the others are passed from an affected parent to half their offspring. ...Read more
Long history: Von Recklinghausen's (NF1) has pictorial history, dating back to thirteenth century. In 1768, Akenside published a scientifically-based description of NF1, recognizing that scholars such as Parè and Aldrovandi, in fact suffered from a disorder of the nerves. Neuromas of NF1 were first detailed by Smith in 1849, but Frederick von Recklinghausen is credited with its discovery and coined the name. ...Read more
Neurofibromatosis: Neurofibromatosis or nf is an inherited disorder or one that occur spontaneously in a patient. It is a disorder that involves the nerves, structures that carry information from the brain to outlying parts of our bodies. In nf there are tumors, which in most cases are benign that arise from these nerves. The disease is extremely variable in how it affects a patient. ...Read more
Many signs: Physician with physical exam can detect many signs of nf. Symptoms of nf1, most common form may be seen at birth and may include light brown spots on the skin ("cafe-au-lait" spots), two or more growths on the iris of the eye, a tumor of optic nerve, a larger than normal head circumference, development of subcutaneous nodules or neurofibromas, abnormal spine, tibia, or other bone. ...Read more
What type?: Nf-1 has classic skin manifestations - one just examines skin to see if criteria for the number/size of nevi and ash-leaf spots on the skin are seen. ...Read more
NF-2: The average life expectancy for someone with NF2 is 65 years of age with appropriate screening and intervention. ...Read more
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