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Doctor insights on: Symptoms Of Mixed Connective Tissue Disease

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What are the major presenting symptoms of mixed connective tissue disease?

What are the major presenting symptoms of mixed connective tissue disease?

Joint, skin, interna: Mctd can have a variety of signs and sympotms whichcan change with times. By the name it is a mixture of a variety of connective tissue diseases: systemic lupus erythematosus, scleroderma, polymyositis and rheumatoid arthritis. Depending on which condition is prominent at the time. When you are evaluated your physician will look for causes of the symptoms from these categories. ...Read more

Tissue (Definition)

The body is composed of tissue that are classically described as beiing derived from three basic embyonic layers known as the endoderm, mesoderm and ectoderm that then differentiate into the structures that compose the body such as skin, soft tissues, bone, muscle, organs, etc. Stem cells are not differentiated and have the potential to ...Read more


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What are some symptoms of connective tissue disease?

What are some symptoms of connective tissue disease?

Connective tissue dz: Most common are fatigue, fevers, muscle and joint pain, stiffness, and weakness. There can be others, making the symptoms non-specific. Speak with your primary physician. ...Read more

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Undifferentiated connective tissue disease.Methotrexate was very effective controlling symptoms but not tolerated due to side effects.Other options?

Undifferentiated connective tissue disease.Methotrexate was very effective controlling symptoms but not tolerated due to side effects.Other options?

That is 4 Ur rheumat: There's others to try but this is not the forum 2 get an answer. Other treatments r available but also have side effects. U need 2 take this up with ur rheumatologist or whoever is caring 4 u. ...Read more

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Ever since symptoms of my undifferent connective tissue disease started, i get indescribable exhaustion very easily despite good sleep & normal labs. Why?

Ever since symptoms of my undifferent connective tissue disease started, i get indescribable exhaustion very easily despite good sleep & normal labs. Why?

See below: If the disease is considered active, the inflammatory molecules such il-6 can mediate fatigue by anemia, cause pain due to swelling, and make you feel unwell. When you get rid of the inflammation, people tend to feel better. ...Read more

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If you have positive cryofibrinogen with symptoms and a history of connective tissue disease, when is it advisable to get opinion of a hematologist? What types of tests would the hematologist run?

If you have positive cryofibrinogen with symptoms and a history of connective tissue disease, when is it advisable to get opinion of a hematologist?   What types of tests would the hematologist run?

A lot: Most hematologists like to run a battery of tests. You want to have a very good insurance for these expensive tests. You may even want a second or third opinion to know if it is necessary to obtain all these tests. You may need a little bit of Prednisone or you may really need a lot of tests. Therefore try to obtain additional opinions. ...Read more

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Rheum treats me 4 unspecif connective tissue disease.Many symptoms & homogen ANA 1:640.All other labs neg.If having sx, why are other labs neg?Frustrating.

More info needed: What are your symptoms? What is your sed rate? From the information given it looks like the doctor is treating the lab work and not the patient. ...Read more

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Is an ANA of 1:640 (multiple times) significant if many of the symptoms of a connective tissue disease are there but other bloodwork including specific antibodies are negative?

Is an ANA of 1:640  (multiple times) significant if many of the symptoms of  a connective tissue disease are there but other bloodwork including specific antibodies are negative?

Probably, but note,: Diagnosis of lupus depends on presence of at least 4 criteria from a multitude of criteria not just symptoms. Examples include arthritis, ana, low white or red blood count, pleurisy, confusion, rash, etc. Some of the criteria may occasionally have different reasons other than lupus. Your doctor can address with you what criteria you may actually have that count towards lupus. ...Read more

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Connective Tissue (Definition)

There are many types of connective tissue, but in general it is a mass of fibers and thick "goopy" fluids secreted by specialized cells. The body often uses connective tissue to help ...Read more