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Doctor insights on: Symptomatic Lupus

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Which percentage of diagnosed lupus cases are sle, systemic lupus erythmatosus?

Which percentage of  diagnosed lupus cases are sle, systemic lupus erythmatosus?

Lupus: Lupus comes in 4 major types: systemic, discoid (skin only), neonatal, and drug-induced. Some people who have an abnormality in their immune system and fail to make a body defense protein called complement are also at risk for developing lupus. It has been estimated that 1.5 million people in the US have one of these lupus forms. Women are 2-3 times more likely to develop this disease than men. ...Read more

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Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

Positif ANA IF, Anti-B2 glicoprotein igM, anti-CMV igG, Lupus Anticoagulants, history of DVT. Dr suspect Antiphospholipid Syndrome (APS). Possible?

POSSIBLE: Your lab outcomes plus the prior DVT, seem consistent, but other labs may further assist such as changes in PTT. Might get additional opinion to confirm your diagnosis, and exclude other problems, but certainly antiphospholipid antibody syndrome seems high on list. ...Read more

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1280 ANA, -ENA and compliments. lupus symptoms, but rheum said no lupus because I have Blau Syndrome, rare autoinflammatory, doesn't cause ANA. Help!

1280 ANA, -ENA and compliments. lupus symptoms, but rheum said no lupus because I have Blau Syndrome, rare autoinflammatory, doesn't cause ANA. Help!

Talk to your MD: Blau syndrome, systemic granulomatous syndrome, is a rare autoimmune disease affecting many organs. It can simulate, at least initially, other autoimmune diseases. There is effective treatment for most patients with the disease. Either talk with your rheumatologist or go to a tertiary medical center. ...Read more

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Ana positive strong family history of lupus. Lupus symptoms. Could it be sarcoidosis instead of lupus.

Maybe: ANA positive diseases are related. Diagnosis is based not just on serologic testing, but also on your clinical symptoms. You should be evaluated by a rheumatologist in order to receive an accurate diagnosis and then receive the most appropriate treatment. ...Read more

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Does having 1 autoimmune disorder predispose u2 others? Mom with hoshimoto's>psoriatic arthritis>viral hepatitis>acute myeloid leukemia.

Does having 1 autoimmune disorder predispose u2 others? Mom with hoshimoto's>psoriatic arthritis>viral hepatitis>acute myeloid leukemia.

Yes: The presence of an autoimmune disorder points to dysregulation of the immune system and thus one is far more likely to have other autoimmune diseases . However, it is not directly linked to viral hepatitis or AML. ...Read more

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Causes of elevated CRP (18.4) and C4 comlement (46)? History: ana, ccp positive. Sjogren's symptoms but ssa/b neg. No arthritis. Fatigued.?

Causes of elevated CRP (18.4) and C4 comlement (46)? History: ana, ccp positive. Sjogren's symptoms but ssa/b neg. No arthritis. Fatigued.?

You have inflammatio: Your tests indicate inflammation. Sjogren's not associated with high inflammation. Ccp positivity fairly specific for ra. Chronic fatigue is common in both RA and sjogrens. And sjogren's (2') common in ra! responds well to Nuvigil or provigil! have you seen a rheumatology specialist to sort things out? ...Read more

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Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Mild Psoriasis sufferer, chronic pain right forarm & elbow. Blood tests 80 titre ana, positive anticentromere. Psoriatic arthritis or scleroderma?

Occam's Razor: Usually Systemic Sclerosis and/or limited Scleroderma is not characterized by arthritis like you describe. The typical biomarker the anti Scl-70 (anti-topoisermorase). Symptoms have to be put into context and better described than elbow and forearm pain. This one you should see a rheumatologist about. Dermatology would be useful as well. Best of luck! ...Read more

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Are discoid lupus and sle different?

Are discoid lupus and sle different?

Yes: Discoid lupus is confined to the skin while systemic lupus can affect literally any organ of the body including the skin. ...Read more

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P-Anca positive, negative MPO??? Wegener's vasculitis suspected due to clinical symptoms. 6 yr old with juvenile arthritis.

P-Anca positive, negative MPO??? Wegener's vasculitis suspected due to clinical symptoms. 6 yr old with juvenile arthritis.

Autoimmune: The positive ANCA test supports the diagnosis of an autoimmune disorder but with a negative MPO test (of one the proteins in the neurophils targeted by the disease) the possible diagnoses are many including Wegener's, RA, and others. Further testing including a biopsy may be required. ...Read more

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Does chronic cutaneous discoid lupus eryhermyosolus turn systemic if you have positive ANA 1:1280 normally.

Does chronic cutaneous discoid lupus eryhermyosolus turn systemic if you have positive ANA 1:1280 normally.

Cutaneous lupus: Systemic lupus erythematosus can follow the rash of discoid lupus, but a high titer ANA does not make that diagnosis without other specific signs and symptoms of systemic lupus ...Read more

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Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Does highly elevated antinuclear antibody result always mean systemic lupus erythematosus?

Not always: Unfortunately, there is no single laboratory test that absolutely rules in or out systemic lupus erythematosis (sle). Although a highly positive antinuclear antigen (ANA) is common in sle, diagnosis is based on a careful history, physical exam and laboratory evaluation. ...Read more

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Feel great - incidental finding ANA 1:160 after acute sinusitis. Then had Anti-DNA, Ant-Smith, SSA/SSB, RNP, SCL-70, Centromere, and Thyroid labs all normal. Does this exclude autoimmune disorder?

False positive ANA: ANA positivity very common in general population. You had the correct assessment showing no common autoimmune diseases. A repeat ANA can be 1:80 as you rid infection. It is a non specific test till titers of 1:640. ...Read more

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What are some alternative therapies for sle (systemic lupus erythematosus)?

What are some alternative therapies for sle (systemic lupus erythematosus)?

None: Diet and omega 3 fatty acids may help but there are no specific vitamin or herbal supplements for sle. Avoiding sugar and dairy is helpful for some people. Omega three fatty acids along with vitamin c and b complex may reduce symptoms. ...Read more

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ANA 1:320 Homogenous pattern, positive ssDNA, and chromatin antibodies 60 u/ml. Fatigue and joint pain. Is lupus a possibility?

Yes: 1:320 along with positive ssDNA Ab and the symptoms you are having makes Systemic Lupus a strong possibility. I suggest seeing a Rheumatologist so they can also evaluate and potentially initiate treatments. ...Read more

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How common ice lupus misdiagnosed for sarcoidosis?

How common ice lupus misdiagnosed for sarcoidosis?

Labs,imaging, biopsy: Lupus and sarcoidosis affects many organs and both can have similar symptoms.However doctor(rheumatologist) can differentiate these two diseases by various blood tests, imaging and sometimes biopsy - skin, liver and kidney depending on the organ involved.So the diagnosis is often clear, raraly misdiagnosed. The diagnosis must be confirmed as the treatment options are quite different. ...Read more

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Have a Positive ANA>320 Atypical Speckled Pattern. CRP ,Sed Rate & RF all wnl. Other SX Reynaud's,dry mouth,butterfly rash,fatigue & joint flare-up's?

Have a Positive ANA>320 Atypical Speckled Pattern. CRP ,Sed Rate  & RF all wnl. Other SX Reynaud's,dry mouth,butterfly rash,fatigue & joint flare-up's?

Need specialist: It sounds like you have one or more of the often-overlapping autoimmune diseases in the lupus / scleroderma / Sjogren's / mixed connective tissue disease family. The real question will be how to treat you. This is why we have rheumatologists. You'll need to partner with your caregiver as you sort through this incredibly confusion area within medicine. Best wishes. ...Read more

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Ana positive, 1:320 centromere pattern. Some joint pain, some swelling, fatigue. Could I have lupus or scleroderma?

Ana positive, 1:320 centromere pattern.  Some joint pain, some swelling, fatigue.  Could I have lupus or scleroderma?

See below: Lab results need to be interpreted in the clinical context and the doctor who ordered the test is usually in the best position to do that. The information you provided suggests scleroderma/crest. See this site for more info and discuss with your doctor. http://www.mayoclinic.com/health/scleroderma/ds00362. ...Read more