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Doctor insights on: Switching From Humira To Enbrel For Arthritis Treatment

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Dr. Thomas Namey
2,426 doctors shared insights

Arthritis (Definition)

A condition where there is progressive degeneration of one or more joints. Symptoms may include joint pain, swelling, decreased motion, and stiffness. The two most common types of arthritis are osteoarthritis, which is associated first with articular cartilage breakdown with a component of inflammation, and rheumatoid arthritis, which is a systemic autoimmune disorder that affects joint linings first and secondarily ...Read more


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Is taking humira (adalimumab) a common treatment for rheumatoid arthritis?

Is taking humira (adalimumab) a common treatment for rheumatoid arthritis?

Yes, but.....: Humira (adalimumab) is quite effective. It is also quite expensive. It should not be considered a first-line therapy, as drug companies want us to believe. Other first line dmards like plaquenyl, methotrexate, leflunomide, and sulfasalazine work quite well. I occasionally will give Humira (adalimumab) injections for several visits until other drugs kick in. ...Read more

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Is methotrexate or humira (adalimumab) better for rheumatoid arthritis?

Is methotrexate or  humira (adalimumab) better for rheumatoid arthritis?

It's u as much as Rx: Again, this is a question for the treating specialist, most likely a rheumatologist. When treating a disorder like ra, there are a variety of medications that have been effective; as with everything else in medicine, no one size fits all, and the right drug or combo for each must be assessed over time by a specialist. ...Read more

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Is remicade (infliximab) the most effective drug for arthritis or chrohns?

Is remicade (infliximab) the most effective drug for arthritis or chrohns?

Maybe: Infliximab (remicade), and the anti-tnf medications including Adalimumab (humira), and certilizumab (cimzia) are all generally a very effective class of medications for crohn's disease. But they are situation dependent. They are less effective if given intermittently or started and stopped again. ...Read more

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How good is enbrel (etanercept) for treating rheumatoid arthritis?

How good is enbrel (etanercept) for treating rheumatoid arthritis?

Very effective.: But frequently unecessary in most of my RA patients. Combinations inclduing mtx with sulfasalazine, hydroxychlorquine, perhaps doxycycline, or Leflunomide should be tried before starting enbrel, (etanercept) unless you have overwhelming inflammatory disease. Noenthless, Enbrel (etanercept) with mtx is better than either alone! ...Read more

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How is enbrel (etanercept) used for treating rheumatoid arthritis?

How is enbrel (etanercept) used for treating rheumatoid arthritis?

Second line.: While Enbrel (etanercept) can be used alone, it works better in tandem with methotrexate. It is given by subcutaneous injection once per week, the dose being dependent on body size. It is also indicated for psoriatic arthritis and spondylitis. Most insurers want the patient to have been on lesser drugs. These would include incomplete response to mtx, sfz, and ho-q. It binds to tnf-alpha, which caues inflamm. ...Read more

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Psoriasis+psor. Arthritis..Methotrexate 15mg for 2 mos. Already+humira weekly..Dr say stelera no good for arthr...Says remicade (infliximab) or enbrel maybe..Ok?

Nod to others:: Humira is a tnfa antibody, and is similar to envbrel. Remicade (infliximab) is an antibody to the tnfa receptor, so it works differently. But i would have tried you on leflunomide, and oral drug, before starting biologics. ...Read more

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Is humira (adalimumab) an effective treatment for psoriasis?

Is humira (adalimumab) an effective treatment for psoriasis?

Yes: Humira (adalimumab) is one of our tnf inhibitors and it is a potent medication. It can quite helpful for psoriasis. You and your physician need to discuss the risks and benefits of the drug versus how bad your psoriasis is. ...Read more

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Humira losing its effectiveness with RA. Unable to tolerate MTX or Plaquenil. Any Rheumotologists think Remicade (infliximab) would be a good option?

Humira losing its effectiveness with RA. Unable to tolerate MTX or Plaquenil. Any Rheumotologists think Remicade (infliximab) would be a good option?

Can't hurt to try: I'm a family doctor, not a rheumatologist, but I do have RA patients who are on Remicaid who are responding very well with it. I don't know what that's worth to you, but I thought I would share. I think it's being used a lot more and does have FDA indication for RA. ...Read more

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What's more effective for pustular psoriasis, methotrexate or enbrel (etanercept)?

What's more effective for pustular psoriasis, methotrexate or enbrel (etanercept)?

Both: Both can be effective, personally i feel Enbrel (etanercept) is safer. There are other options. Talk it over with your dermatologist. ...Read more

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Is anti-tfn infliximab and effective treatment for rheumatoid arthritis. ?

Is anti-tfn infliximab and effective treatment for rheumatoid arthritis. ?

Yes: The biologic drugs, of which the tnf inhibitors are one , are new and exciting medications that are changing the course of RA by interfering with the body's productiion of inflammatory components; in addition they decrease the joint damage. Ther arenow 5 tnf inhibitors, an il-6 inhibitor, and several b cell inhibitors as well as new jak enzyme inhibitors in investigation. ...Read more

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RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?

RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?

RA + psoriasis: There are a number of newer medications that could help you. Xeljanz works by disrupting cytokine and growth factor signaling pathways. A trial of the medication is useful to see whether it helps you. Other medications that might help include Remicade (infliximab) and Apremilast ...Read more

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Is there a difference in humira and enbrel (etanercept) treatment of psoriasis?

No great...: No great differences. Enbrel (etanercept) is once weekly and Humira is once every two weeks. They have similar efficacy in large trials, but differences exist between individuals! both should be tried only after Methotrexate therapy has failed! ...Read more

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How effective is infliximab in treating psoriatic arthritis?

How effective is infliximab in treating psoriatic arthritis?

Quite effective!: Infliximab is quite effective in treating both psoriasis and psoriatic arthritis, but it is not and should be not a first line therapy. ...Read more

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What is your view of humira (adalimumab) as a treatment for hs. Antibiotics and cortisone injections had zero effect for me. Dermatologists?

What is your view of humira (adalimumab) as a treatment for hs. Antibiotics and cortisone injections had zero effect for me. Dermatologists?

See details: As a rule, tnf agents such as Humira are not very effective for small vessel vasculitis such as hs purpura. Imo, Rituxan (rituximab) would be a better choice for refractory disease. Humira is not an approved therapy for hs purpura. ...Read more

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Psoriasis+psor. Arthritis..Methotrexate 15mg for 2 mos. Already+humira weekly..Dr say stelera no good for arthr...Says remicade (infliximab) or enbrel maybe..Ok?

Nod to others:: Humira is a tnfa antibody, and is similar to envbrel. Remicade (infliximab) is an antibody to the tnfa receptor, so it works differently. But i would have tried you on leflunomide, and oral drug, before starting biologics. ...Read more

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Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, (etanercept) humira...). Feeling defeated. What else can I try?

Rheumatoid arthritis for 7 yrs. On methotrexate & prednisone. Tried so many drugs (orencia, enbrel, (etanercept) humira...). Feeling defeated. What else can I try?

Other choices: Some older drugs such as Plaquenil may help, especially with fatigue. There are also newer drugs that act via different mechanisms such as actemra (tocilizumab). I assume the diagnosis of RA is definite. If not, retest other possibilities. An exercise program may be very beneficial, especially if you start slowly and build up with hurting yourself. Don't give up hope. You can get better. ...Read more

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Is there a difference in humira and enbrel (etanercept) treatment of psoriasis?

No great...: No great differences. Enbrel (etanercept) is once weekly and Humira is once every two weeks. They have similar efficacy in large trials, but differences exist between individuals! both should be tried only after Methotrexate therapy has failed! ...Read more

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What is it like to have any experience with blood monitoring for anti tnf therapy (humira/enbrel) whilst traveling for multi stop flights abroad?

What is it like to have any experience with blood monitoring for anti tnf therapy (humira/enbrel) whilst traveling for multi stop flights abroad?

See details: People who are stable on TNF biologics do not require blood test monitoring more than once every 3 months. Those in my practice who have been stable for years only have monitoring every 6 months. ...Read more

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Was on humira (adalimumab) weekly&psoriasis came back. Now on enbrel&25mg methotraxte.Do u think psorias will clear?Y did humira (adalimumab) stop working?Stress overpower it?

Both work: It's your these medicines are effective. The reason medication stop working may depend on many factors. Sometimes the body develops resistance to a medication that is working fine. The resistance can occur because of antibodies against the drug. It can also occur because the mechanism of the disease of the illness can change differently at the molecular level. You doctor can better answer this. ...Read more

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I was on humira and felt terrible, is enbrel (etanercept) any better?

Switching meds: The current recommendation is to try a medication with a different mechanism of action. That being said, before there were so many options, switching between Enbrel and Humira was quite common. Sometimes it helps, just as sometimes one pill in a class of drugs works better than another. ...Read more

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On actemra (tocilizumab) IV(dose increase in dec)and methotrexate for 5 mon now but still having bad flare ups. Tried humira,enbrel,etc. since diagnosis in Dec 2013?

Your question is?: Your have not asked a question. This issue needs to be discussed with your rheumatologist. No one can give you specific advice over the internet without a complete history and exam. ...Read more

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Child has JRA failed enbrel and had side effects from it so dr gave choice humira or remicade (infliximab) Which is better ? I'm confused snd do know what to do!

Child has JRA failed enbrel and had side effects from it so dr gave choice humira or remicade (infliximab)   Which is better ? I'm confused snd do know what to do!

TNF Inhibitors: All of the medications offered to your child work in similar ways the difference is how the meds are given. Humira (adalimumab) is an injection that can be done at home every two weeks, while remicaide is an IV medication that must be done in an infusion unit or hospital. These medication have similar side effects and benefits. My advice is try the medication that is least disruptive to your lifestyle. ...Read more

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Is there a waiting period between changing from enbrel (etanercept) to humira? If so, how long? Then how long before humira begins to work?

Is there a waiting period between changing from enbrel (etanercept) to humira? If so, how long? Then how long before humira begins to work?

One week: I would start Humira one week after your last Enbrel (etanercept) injection. There is no hard and fast rule. I have seen Humira work as quickly as within two weeks and as long as three months. These medications should be given for at least three months before switching. Good luck. ...Read more

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What are the side effects of tnf inhibitors such as humira and enbrel (etanercept)?

See below: The important side effects that have been most extensively related to tnf blockers include: lymphoma, infections including tuberculosis, congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects. ...Read more

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What's average amount of time people can take biologics (ex: humira (adalimumab) or enbrel) before developing an immunity to it? Do all patients develop immunity?

See below: Patients are more apt to develop resistance to biologic if they are not on methotrexate. However; not all patients are candidate to be on methotrexate. Some patients never have a problem and some do. It is hard to comment on the average amount of time because it is an individual phenomena. ...Read more

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My RA doc wants me to take Enbrel/ Humira (adalimumab). Very afraid of the side effects & I'm already blind in 1 eye. What else can I take instead?

My RA doc wants me to take Enbrel/ Humira (adalimumab). Very afraid of the side effects & I'm already blind in 1 eye. What else can I take instead?

Talk to RA doctor: These are issues which need be discussed with your RA doctor. In medicine, most decisions made are based on risk/benefit ratio and without knowing that, it is impossible to provide you with an answer in this type of interaction. ...Read more

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RA + psoriasis. MTX allergy. Enbrel (etanercept) non effective. Humira semi-effective but Vectra score 30 with extreme fatigue. MD wants to try Xeljanz?

RA + psoriasis: There are a number of newer medications that could help you. Xeljanz works by disrupting cytokine and growth factor signaling pathways. A trial of the medication is useful to see whether it helps you. Other medications that might help include Remicade (infliximab) and Apremilast ...Read more

Dr. Robert Lowe
1,559 doctors shared insights

Painful Joints (Definition)

That term is not really a specific diagnosis, but rather somewhat of a general term. The medical term is arthralgias, which implies pain in multiple joint possibly coming from a single cause. Don't hesitate to be seen and evaluated for ...Read more


Dr. Robert Lowe
125 doctors shared insights

Etanercept (Definition)

Etanercept is an immune system suppressor which is a kind of ...Read more