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Doctor insights on: Suspicious Thyroid Nodule Biopsy

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Has anyone ever had a thyroid nodule biopsy without pain?

Has anyone ever had a thyroid nodule biopsy without pain?

Yes.: The pain experienced after a thyroid nodule biopsy is highly variable. Depending on the size of the needle used, whether local anesthetic was given, and individual technique these factors will influence whether you have pain or not. There is also variation from one patient to the next. Generally speaking, the pain experienced is mild. ...Read more

Dr. Neigatha Graney
2 doctors shared insights

Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more


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Thyroid nodule stable. What if I refuse a biopsy? Don't want cost or risk

Ok to refuse: If the thyroid nodule is stable like you said, there is no need for a repeat biopsy (unless the last one didn't get enough materials or if your doctor was concerned about something with the last biopsy). Discuss this thoroughly with your physician. As long as you continue to follow the nodule, you will be able to intervene sooner if something changes. ...Read more

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I have had two inconclusive biopsies on a thyroid nodule. Mwhat do you suggest I do?

I have had two inconclusive biopsies on a thyroid nodule. Mwhat do you suggest I do?

Thyroid nodule: You may want to discuss with your doctor about ultrasound for cyst or solid and thyroid scan for hot and cold nodule also thyroid antibodies and thyroglobulin. Usually these tests are done before biopsy. Since you did not mention and I assumed they are not done. Therefore, recommending them. What was the basis for biopsy? Physical exam or one of these tests? ...Read more

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Should a 3.2 CM thyroid nodule with an inconclusive biopsy be removed simply because of size?

Should a 3.2 CM thyroid nodule with an inconclusive biopsy be removed simply because of size?

Maybe: Most "inconclusive" thyroid biopsies are fine needle biopsies (fnas). "Inconclusive" ones are usually benign but occasionally are not, and this can only be established with a proper surgical excision and full pathology examination. This is the reason to remove a nodule... Not its size. ...Read more

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Should biopsy be done on less than 1cm thyroid nodules with irregular borders? Why? Will it be accurate?

Should biopsy be done on less than 1cm thyroid nodules with irregular borders? Why? Will it be accurate?

Depends: This depends on many factors — the presence of other signs (microcalcifications), the rate of growth, history of thyroid cancer in your family, the presence of thyroiditis, and the skill of th person doing the biopsy (should only be done with the use of an ultrasound as its probably too small to palpate). But generally if it's amenable to biopsy I would recommend it. Can also recheck it in 3-6 mo. ...Read more

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Can a thyroid nodule biopsy results ever be wrong?

Can a thyroid nodule biopsy results ever be wrong?

Yes: In general, if a nodule is very large, there is a higher chance that it can be called benign although it still could be cancerous because not all the nodule is typically cancerous. You could have one little speck of cancer that hide within the big mass and a biopsy could miss it because we can't "poke" you forever. However, if a biopsy came back "cancerous", it almost always is true. ...Read more

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Does a solid 1.1 CM thyroid nodule need to be biopsy?

Does a solid 1.1 CM thyroid nodule need to be biopsy?

Yes: Solid nodules carry the risk of being thyroid cancer (although certainly most solid thyroid nodules are not cancer). Because of the risk, you should have a biopsy done (most can be done using a very thin needle while an ultrasound is being done). ...Read more

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Thyroid nodule, blood and biopsy fine. What the next step.

Thyroid nodule, blood and biopsy fine. What the next step.

Good: Now relax, and go for your doctors regular scheduled follow up appointments. ...Read more

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If they just found a 1.1 CM solid thyroid nodule how fast should I get it biopsy will this starts to grow very quickly?

If they just found a 1.1 CM solid thyroid nodule how fast should I get it biopsy will this starts to grow very quickly?

Depends: You can get a fine needle aspiration, which is relatively non-invasive to obtain a diagnosis. Getting the advice of your clinician on this matter because he/she knows your clinical situation is recommended. ...Read more

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Thyroid Nodules 3.6 left 3.4 right Is a needle biopsy practical at this size? Should we just schedule removal of the thyroid.

Thyroid Nodules 3.6 left 3.4 right Is a needle biopsy practical at this size? Should we just schedule removal of the thyroid.

Big nodules: Hi. Those are big nodules. They should only have FNAB done if you plan to NOT remove them if they're benign. If they're bugging you and you want them out even if they're benign, then you can skip FNAB. ...Read more

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4 weeks ago I had a biopsy done on a thyroid nodule which came back clear but I feel poorly, with symptoms of thyroid problems could it have changed?

4 weeks ago I had a biopsy done on a thyroid nodule which came back clear but I feel poorly, with symptoms of thyroid problems could it have changed?

Thyroid nodule: Usually don't cause symptoms unless large and pushing on nearby structures. Was your thyroid level checked and if so was it normal. If not checked it is a simple blood test so discuss with your doctor. ...Read more

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I have bilateral partially cystic thyroid nodules. Biopsy done of the larger one, came back "follicular lesion of unknown origin" what does that mean?

I have bilateral partially cystic thyroid nodules. Biopsy done of the larger one, came back "follicular lesion of unknown origin" what does that mean?

Variable meaning: Follicular?patterned lesions of the thyroid are common; these include hyperplastic/adenomatoid nodules, follicular adenoma, follicular carcinoma and follicular variants of papillary carcinoma. Repeat biopsy with a sample sent for a genetic afirma assay may give additional useful information. In addition, discuss with your endocrinologist. ...Read more

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Repeated thyroid nodule biopsy cold solid 3x7cm. How could he not get enough cells with such a large nodule? Also, 2.4cm cold follicularGenetic testing

Possible: May be if nodule has fluid (Cyst) may not get cells (how many times was done? More than twice is unusual) . If strongly suspicious for malignancy an image guided core needle biopsy, or even removal (surgery) Discuss with your doctor, plan of treatment Do not ignore if necessary take second opinion. ...Read more

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Why do I need another ultrasound after biopsy for thyroid nodule?

Why do I need another ultrasound after biopsy for thyroid nodule?

If it was inconclusi: If it wasn't a good sample, was inconclusive, or another biopsy needs to be done to obtain tissue for an afirma genetic assay. Ask your doctor. Biopsies cannot 100% prove the absence of cancer. ...Read more

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I have a 5 CM thyroid nodule w/ blood flow, report says needs biopsy, what does this mean?

I have a 5 CM thyroid nodule w/ blood flow, report says needs biopsy, what does this mean?

Needle biopsy : Nodules of that size can be biopsied using a technique called fine needle aspiration. The skin over the nodule is numbed with a local anesthetic. Then, usually with ultrasound guidance, a needle is passed through the skin into the nodule. A small sample is taken and then analyzed under a microscope. ...Read more

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Why do I need another ultrasound after biopsy for thyroid nodule I had an ultrasound ten days ago?

Why do I need another ultrasound after biopsy for thyroid nodule I had an ultrasound ten days ago?

No: Not unless there has been a significant clinical change or another biopsy is required. Repeat biopsy will be necessary at intervals to evaluate progress and possible therapies. ...Read more

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I'm 28 years old, had a thyroid nodule for 2 years. Finally, got a biopsy. How likely is it to be cancer?

I'm 28 years old, had a thyroid nodule for 2 years. Finally, got a biopsy. How likely is it to be cancer?

Likelihood: Depends on size, whether it is solid, cystic, or complex, whether it is a "cold" nodule, and a lot of other things. Even if it is thyroid cancer, most of these are successfully treated with surgery with or without radiotherapy. ...Read more

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Diagnosed with multiple thyroid nodules and going back to talk about options or biopsy. What options are there other than biopsy?

Diagnosed with multiple thyroid nodules and going back to talk about options or biopsy. What options are there other than biopsy?

Several options: Belfry: the fact that there are multiple nodules means that it is likely a benign multinodular goiter. Sometimes these are just watched with serial ultrasound exams as well as following your bloodwork. A biopsy is a fine needle aspiration and is minimally invasive. It is well-tolerated and you should do it if there is an atypical or dominant nodule that stands out from the rest. ...Read more

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My thyroid level increased from .92 to 1.2 now 1.63 over 3 year period. Had 1cm thyroid nodules a year ago biopsied no result. Hot flashes related?

My thyroid level increased from .92 to 1.2 now 1.63 over 3 year period. Had 1cm thyroid nodules a year ago biopsied no result.  Hot flashes related?

Need more data:: You might be hyperthyroid, but a low TSH would confirm this. Also, you need a free T3 & T4 done. If TSH low you need thyroid stimulating IgG. The measurements do not specify what was measured: total or free & T3 or T4. ...Read more

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Complex thyroid nodule biopsied said to be benign... Now regardless of the diagnosis... Could it be possible that nodule is cancerous and biopsy missed it?

Possibly: Thyroid nodules are notoriously difficult to interpret biopsy results, because the nodules themselves are often "complex" meaning non-uniform, and thus one portion may look benign while the other malignant,. ...Read more

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Is a thyroid nodule fna biopsy painful?

Is a thyroid nodule fna biopsy painful?

It varies: The level of discomfort experienced can vary considerably. Different people have different pain tolerance. Inflammatory nodules are likely to be more tender than cysts or tumors. Different doctors choose different size needles. Some use lidocaine, a local anesthetic, some do not. Most patients experience a level of pain similar to what they feel while getting an IV started. ...Read more

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Can another fna thyroid nodule biopsy be taken 2 weeks after a previous fna biopsy?

Better to wait: Cytopathologists may preferr that you wait a couple of months if it is slightly suspicious but inconclusive. Inflammation can make interpretion harder. On the other hand, if the fna was nondiagnostic because of too few cells, it is desirable to repeat it within a reasonably short period. ...Read more

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What issues can mild von willebrand cause during a thyroid nodule biopsy? Anything to be concerned about?

Bleeding with a bx: There is some increased risk but careful technique should help reduce the risk. If the nodule is worrisome it is worth the risk to biopsy. Good luck. ...Read more

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What do these biopsy results of thyroid nodule mean ATYPIA OF UNDETERMINED SIGNIFICANCE OR FOLLICULAR LESION OF UNDETERMINED SIGNIFICANCE?

Re-FNA in 3-6 Months: Hi Jami, AUS/FLUS is a term that cytopathologists use for thyroid nodules that they basically are "unsure" about. Classic management for this diagnosis is to have a second repeat FNA in 3-6months. Nowadays though high tech molecular pathology tests can sometimes divide AUS/FLUS definitively into benign and malignant categories. Please setup a virtual consult with me for more information. ...Read more

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1.5mm (yes, tiny) thyroid nodule found on ultrasound. Not characterized in any way except "solid nodule". Possible to biopsy at this stage?

Nodule too tiny: Biopsy of a 1.5 mm thyroid nodule would be difficult. Most biopsies occur when nodules reach a size of 1.0 to 1.5 cm. You should have follow up ultrasound scan probably in 3 – 6 months. ...Read more

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Which doctor specializes in thyroid nodule biopsy? Does it have to be a surgeon?

Which doctor specializes in thyroid nodule biopsy? Does it have to be a surgeon?

It's usually an ENT: Endocrinologist or interventional radiologist who does the procedure. Take care! ...Read more

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Homogeneous solid thyroid nodule measuring 1.6x1.9x2.8cm increased peripheral and intranodular blood flow. Had biopsy. How suspicious and concerning?

Worth a Biopsy: It was suspicious enough to warrant a biopsy. You had one. The results will be back soon and you will know one way or another. Most turn out to be benign. ...Read more

Nodule (Definition)

Any growth or deposit in the body or on its surface may be casually termed a nodule until its character is determined by the familiarity of the physician with it or by the results of a biopsy if it is not so obvious. The term is casual ...Read more


Dr. Abraham Jaskiel
13 doctors shared insights

Thyroid (Definition)

The thyroid is an endocrine gland that sits in the lower part of the neck. It produces thyroid hormone - which ...Read more