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Doctor insights on: Sulfasalazine

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Dr. Jeremy Adler
113 doctors shared insights

Sulfasalazine (Overview)

Sulfasalazine is a gastroenterology drug.


Dr. Jeremy Adler
113 doctors shared insights

Sulfasalazine (Overview)

Sulfasalazine is a gastroenterology drug.


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Does anyone have problems with this drug, sulfasalazine?

Does anyone have problems with this drug, sulfasalazine?

Yes, sometimes: Up until the 80's we only had sulasalazine for uc. The main problems were headace and some rqshes usually due to the sulfapyridine moiety. Pure Mesalamine drugs such as asacol, (mesalamine) lialda, Balsalazide and others do not contain the sulapyridine part and therefore don't have as many problems with the drug. However sulfasalazine is still cheap and useful and should not be ignored. ...Read more

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Has anyone prescribed sulfasalazine for costochondritis?

Has anyone prescribed sulfasalazine for costochondritis?

No: The use of sulfasalazine would be very unusual for this inflammatory condition. Local heat, anti-inflammatory rx, steroid injection ( with caution), some types of physical therapy are the usual treatments. ...Read more

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Can voltarin gel be used wbile taking sulfasalazine, tramadol and prednisone?

Can voltarin gel be used wbile taking sulfasalazine, tramadol and prednisone?

Ues: The good thing about the gel is that it is used exactly at the location where it is needed. It is not absorbed in the bloodstream in large amounts to have side effects on kidneys or stomach lining, for instance. It is safe to use with the other meds. ...Read more

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Is sulfasalazine effective in treating hives/allergies?

Is sulfasalazine effective in treating hives/allergies?

Yes, but...: Urticaria (hives) are often due to a food or medication reaction when acute & are usually easily managed with antihistamines. When hives do not respond to antihistamines or become chronic, anti-inflammatory medicines are often used. First-line treatment is usually with corticosteroids, but when hives persist, other anti-inflammatory agents including sulfasalazine have been used with some success. ...Read more

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Is it safe to take sulfasalazine while pregnant or breastfeeding?

Is it safe to take sulfasalazine while pregnant or breastfeeding?

Probably, but ask OB: Adverse events have not been observed in animal reproduction studies.Sulfasalazine and sulfapyridine cross the placenta; a potential for kernicterus in the newborn exists.Based on available data, an increase in malformations in the developing fetus has not been observed following maternal use of sulfasalazine. As always, discuss this with both OB and your rheumatogist.Do not stop meds on your own. ...Read more

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Can the arthritis drug sulfasalazine cause mouth ulcers and a sore mouth?

Can the arthritis drug sulfasalazine cause mouth ulcers and a sore mouth?

Check with doc: Check with your doc, you may be allergic to it-try switching to a different med. ...Read more

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How long does sulfasalazine stay in your system?

How long does sulfasalazine stay in your system?

It depends: Sulfasalazine has a half life of 7.6 hr on avg. It's a short acting medication which is why it requires every 6-12 hour dosing. A drug is cleared from system entirely after 10 half lives so the drug should theoretically be cleared in 76 hrs or a little over 3 days. The metabolite of sulfasalazine, sulfapyridine has a half life of 10.4-14.8 h so it's cleared in 148 hrs from system ...Read more

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Sulfasalazine, started taking it a week ago, 3x2 daily. Constant migraine and nausea. How long can I expect this to last?

Sulfasalazine, started taking it a week ago, 3x2 daily. Constant migraine and nausea. How long can I expect this to last?

See details: Nausea is the most common side effect of sulfasalazine. Your starting dose was awfully high. I start patients at a much lower dose and gradually increase because of the nausea risk. Speak with your doctor. In the end, this may not be the best choice for you. ...Read more

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