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Doctor insights on: Subcortical White Matter

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What does scattered althought predominantely bilateral frontal, subcortical white matter punctuate foci of signal abnormality mean?

Normal in most cases: This is a common finding on MRI brain. In most cases this could be a normal finding, however, history of migraine, smoking, dm and high cholesterol may increase risk for white matter lesions. You should seek a consultation with neurologist. ...Read more

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White Matter (Definition)

White matter is one of the two components of the central nervous system and consists of glial cells and myelinated axons that transmit signals from one region of the cerebrum to another and between the cerebrum and lower brain centers. White matter tissue of the freshly cut brain appears pinkish white to the naked eye because myelin is composed largely of lipid ...Read more


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Hi. Would would an MRI showing scattered foci of bifrontal subcortical white matter abnormal signal mean for a 23 year old female?

Hi. Would would an MRI showing scattered foci of bifrontal subcortical white matter abnormal signal mean for a 23 year old female?

Perhaps nonspecific: As such lesions may be seen with prior head trauma, smoking, migraine, hypertension, some chemotherapy agents, recreational drugs, and MS. Schedule a full conference with your doctor and discuss both significance and next steps. ...Read more

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Solitary focus abnormal signal frontal subcortical white matter nonspecific for this young pt. This is MRI report. All labs normal. What does mean?

Solitary focus abnormal signal frontal subcortical white matter nonspecific for this young pt. This is MRI report. All labs normal. What does mean?

Depends: on size, clinical setting, etc. OVerall, likely nothing, we see numerous cases of UBOs in neurology on brain MRIs (Unidentified bright objects). ...Read more

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I have had a MRI for migraines what does the results mean multiple punctate t2 hypertintense foci in subcortical white matter bilaterally?

I have had a MRI for migraines what does the results mean multiple punctate t2 hypertintense foci in subcortical white matter bilaterally?

No worries: These are areas of subclinical (non-symptomatic) strokes. Suggest low fat diet, cholesterol check, blood pressure control as this could be a predictor of worsening vascular disease in future. See your internist. ...Read more

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An MRI revealed thre are few tiny nonspecific foci of increased t2 weigted signal in the perivaentricular and subcortical white matter? Concerns?

No: Those t2 signals are often incidental findings. They are more common in migraine patients and patients with higher blood pressure. 2 tiny t2 lesions alone are not sufficient to diagnose multiple sclerosis. The MRI needs to be seen in conjunction with the clinical picture. Why did you get the mri? ...Read more

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What does my mri results mean by there are a few scattered patchy t2/flair hyperintense lesions in both deep and superficial subcortical white matter?

What does my mri results mean by there are a few scattered patchy t2/flair hyperintense lesions in both deep and superficial subcortical white matter?

Ask referring doc: Even if your pictures look exactly like the one here (scattered T2 abnormalities in a woman of your age), you still wouldn't have an answer without further Dr's. exam and a detailed history. You likely had some reason to have the study done and that reason is very important to establishing a diagnosis. Sorry I can't put your mind at ease. You will need a neurologist to sort it out. ...Read more

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Bilateral frontal lobe subcortical white matter showing evidence of small vessel ischemic changes. Is this serious?

Bilateral frontal lobe subcortical white matter showing evidence of small vessel ischemic changes. Is this serious?

NONSPECIFIC : Although the films were read as suggesting ischemia, location might also suggest prior head trauma, congenital lesions of no consequence, genetic or hereditary issues, even underlying inflammatory condition. This is only "serious", if clinically you are having stroke symptoms or you possess uncontrolled blood pressure or elevation of blood lipids. Likely quite non-diagnostic. ...Read more

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Bilateral frontal lobe subcortical white matter showing evidence of small vessel ischemic changes. What does this mean?

Subcortical ischemia: This translates to changes in the smaller blood vessels that lead to loss of blood flow to the area and then scarring. Somewhat like a small silent stroke and frequently seen in people with migraines. The opinions about this have swayed from very worried, to common and mundane and more recently back to looking to stop the damage (help the blood flow, oxygen and glucose status optimize). ...Read more