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Doctor insights on: Strongest Neuroleptic Malignant Syndrome

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What causes neuroleptic malignant syndrome?

What causes neuroleptic malignant syndrome?

NMS: Neuroleptics (antipsychotics) block certain Dopamine receptors in the hypothalamus (hypothalamic d-2 receptors) resulting in an elevated temperature set point and  impairment of the bodies ability to dissipate heat; it is also associated with blockade of other Dopamine receptors, which can  result in muscle rigidity and increased body temperature.. ...Read more

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Malignant (Definition)

The term malignant can be used in several medical contexts, but is primarily used to describe cancers. More dangerous and disorderly than the benign growth of cells, malignant cells have developed genetic changes that can allow it to invade other tissues in an unregulated way. These tumors can later spread, or metastasize, to other parts of the body and ...Read more


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How do you treat neuroleptic malignant syndrome?

How do you treat neuroleptic malignant syndrome?

Emergency : The most important thing is to stop any antipsychotic medication. Supportive treatment in a closely monitored setting. Some medications like bromocriptine or amantadine may also be used. ...Read more

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Who is at risk of neuroleptic malignant syndrome?

NMS: Can occur in anyone exposed to a neuroleptic/ drug blocker d2 (dopamine receptos). Although it can occur at any time during treatment it is more common after starting the medication or increasing the dose. It is very rare with  an incidence of 0.07-0.2%. Men are at greater risk than women. Other risk factors include  history of nms, increased environmental temperature,  dehydration,  agitation. ...Read more

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Can you please define neuroleptic malignant syndrome?

NMS: Neuroleptic malignant syndrome (nms) is a rare, but life-threatening, idiosyncratic reaction to a neuroleptic (antipsychotic) medication. The syndrome is characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction. ...Read more

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How to tell if I have neuroleptic malignant syndrome?

You don't. : Nms is so severe that you will not be asking questions. Google can be good resource if you need to know more. ...Read more

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What are the tests for neuroleptic malignant syndrome?

What are the tests for neuroleptic malignant syndrome?

Several!: Neuroleptic malignant syndrome is a diagnosis of exclusion, so we have to make sure there isn't another problem like an infection. Blood count may show high white blood cells, urine test may have myoglobin. If tests like blood and urine culture show no signs of infection, ct/mri of the head show no brain problems and the patient is on or has taken an antipsychotic this points us towards nms. ...Read more

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Is the neuroleptic malignant syndrome really malignant?

Is the neuroleptic malignant syndrome really malignant?

NO!: Neuroleptic malignant syndrome (nms) is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Nms typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated plasma creatine phosphokinase. ...Read more

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What are the symptoms of neuroleptic malignant syndrome?

What are the symptoms of neuroleptic malignant syndrome?

Fever, stiff muscles: Fever, stiff muscles, changes in personality and thinking, and autonomic instability (racing heart, low or high blood pressure, sweating, leaking urine...) are symptoms of neuroleptic malignant syndrome. This is a very serious and life-threatening reaction to treatment with antipsychotic medications or withdrawal from certain medications. ...Read more

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Could you explain what is neuroleptic malignant syndrome?

Complicated : "life-threatening condition that may develop anytime during therapy with neuroleptics—from a few days to many years (but 2/3 of cases occur within the 1st week). Muscular rigidity from Dopamine antagonism in the nigrostriatal pathway. Hyperthermia due to blockage of hypothalamic thermoregulation (more likely in the setting of benzodiazepine withdrawal)" from lexi drugs. ...Read more

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What are the best home remedies for neuroleptic malignant syndrome?

None that I know of!: Real neuroleptic malignant syndrome is not a condition for home remedies. It is related to medications and is a very serious condition which almost always requires treatment in the hospital to manage the fever, unstable blood pressure, muscle rigidity, and other problems that are characteristic of this syndrome. The medication that caused nms to develop must be identified and stopped. ...Read more

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Dr. John Moranville
344 doctors shared insights

Antipsychotics (Definition)

These are medications used among other things to treat psychosis. There are two poorly named classes: the typicals, because they used to be typically used, and the atypicals, which are now typically used. They differ in that the so called atypicals are non-neuroleptics and interact with both serotonin and Dopamine receptos, while the typicals ...Read more


Dr. Scott Mackinnon
85 doctors shared insights

Neuroleptic Malignant Syndrome (Definition)

Neuroleptic malignant syndrome is a rare, but potentially fatal, condition that is a reaction to taking an antipsychotic medication. Common symptoms include fever, muscle stiffness, and ...Read more