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Doctor insights on: Strongest Neuroleptic Malignant Syndrome

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Is the neuroleptic malignant syndrome really malignant?

Is the neuroleptic malignant syndrome really malignant?

NO!: Neuroleptic malignant syndrome (nms) is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs. Nms typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated plasma creatine phosphokinase. ...Read more

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Dr. Heidi Fowler
379 doctors shared insights

Antipsychotics (Definition)

These are medications used among other things to treat psychosis. There are two poorly named classes: the typicals, because they used to be typically used, and the atypicals, which are now typically used. They differ in that the so called atypicals are non-neuroleptics and interact with both serotonin and Dopamine receptos, while the typicals ...Read more


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What causes neuroleptic malignant syndrome?

What causes neuroleptic malignant syndrome?

NMS: Neuroleptics (antipsychotics) block certain Dopamine receptors in the hypothalamus (hypothalamic d-2 receptors) resulting in an elevated temperature set point and  impairment of the bodies ability to dissipate heat; it is also associated with blockade of other Dopamine receptors, which can  result in muscle rigidity and increased body temperature.. ...Read more

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Does Abilify (aripiprazole) causes neuroleptic malignant syndrome?

Possible with med: Abilify/aripiprazole is an antipsychotic medication that has the potential to cause the rare but possibly life-threatening condition known as neuroleptic malignant syndrome (nms). Nms usually results from combining multiple antipsychotics (abilify plus others) in high dose all at once which overwhelms the body: muscle rigidity/fever/neurologic instability; unlikely to happen if take as prescribed. ...Read more

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Can Neurontin (gabapentin) cause neuroleptic malignant syndrome?

Can  Neurontin (gabapentin) cause neuroleptic malignant syndrome?

Neurontin (gabapentin): Rare cases of nms reported when Neurontin (gabapentin) combined with other anti-seizure medications such as tegretol. We have not encountered cases in our practice. ...Read more

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Who is at risk of neuroleptic malignant syndrome?

NMS: Can occur in anyone exposed to a neuroleptic/ drug blocker d2 (dopamine receptos). Although it can occur at any time during treatment it is more common after starting the medication or increasing the dose. It is very rare with  an incidence of 0.07-0.2%. Men are at greater risk than women. Other risk factors include  history of nms, increased environmental temperature,  dehydration,  agitation. ...Read more

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I heard Abilify (aripiprazole) causes neuroleptic malignant syndrome. Is this true?

I heard Abilify (aripiprazole) causes neuroleptic malignant syndrome. Is this true?

Possible with med: Abilify/aripiprazole is an antipsychotic medication that has the potential to cause the rare but possibly life-threatening condition known as neuroleptic malignant syndrome (nms). Nms usually results from combining multiple antipsychotics (abilify plus others) in high dose all at once which overwhelms the body: muscle rigidity/fever/neurologic instability; unlikely to happen if take as prescribed. ...Read more

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Is it possible that the drug Neurontin (gabapentin) cause neuroleptic malignant syndrome?

No: I have not been able to find any data that says that it can. It has no effect on Dopamine either, so it should not be expected to. Best wishes and happy holidays. ...Read more

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How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

How is mast cell activation syndrome diagnostically differentiated from carcinoid syndrome?

Totally different: The chemical mediators for these two conditions are totally different even though both can cause flushing. MCAS can be diagnosed by a blood test, carcinoid usually a urine test. ...Read more

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What are the symptoms of neuroleptic malignant syndrome?

What are the symptoms of neuroleptic malignant syndrome?

Fever, stiff muscles: Fever, stiff muscles, changes in personality and thinking, and autonomic instability (racing heart, low or high blood pressure, sweating, leaking urine...) are symptoms of neuroleptic malignant syndrome. This is a very serious and life-threatening reaction to treatment with antipsychotic medications or withdrawal from certain medications. ...Read more

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What are the tests for neuroleptic malignant syndrome?

What are the tests for neuroleptic malignant syndrome?

Several!: Neuroleptic malignant syndrome is a diagnosis of exclusion, so we have to make sure there isn't another problem like an infection. Blood count may show high white blood cells, urine test may have myoglobin. If tests like blood and urine culture show no signs of infection, ct/mri of the head show no brain problems and the patient is on or has taken an antipsychotic this points us towards nms. ...Read more

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Can one time use of phenergan cause neuroleptic malignant syndrome?

Can one time use of phenergan cause neuroleptic malignant syndrome?

Unlikely: Neuroleptic malignant syndrome has been rarely observed during treatment with promethazine. It usually occurs within the first 30 days after exposure to neuroleptics. One case noted in 1999: Neuroleptic malignant syndrome due to promethazine. Chan-Tack KM1. It occurred after 2 days in this case. If suspected it is an emergency situation. ...Read more

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Can you please define neuroleptic malignant syndrome?

NMS: Neuroleptic malignant syndrome (nms) is a rare, but life-threatening, idiosyncratic reaction to a neuroleptic (antipsychotic) medication. The syndrome is characterized by fever, muscular rigidity, altered mental status, and autonomic dysfunction. ...Read more

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What is neuroleptic malignant syndrome? Is it treatable?

NMS: Neuroleptic malignant syndrome is a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic drugs (ex: haldol, (haloperidol) droperidol). NMS typically consists of muscle rigidity, fever, autonomic instability, and cognitive changes such as delirium, and is associated with elevated CPK. ...Read more

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Is there any doctor with experience of seeing patients with Cowden's syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN hamartoma tumour syndrome?

Is there any doctor with experience of seeing patients with Cowden's syndrome, Bannayan-Riley-Ruvalcaba syndrome, PTEN hamartoma tumour syndrome?

Cowden Syndrome: http://ghr.nlm.nih.gov/condition/bannayan-riley-ruvalcaba-syndrome http://ghr.nlm.nih.gov/condition/cowden-syndrome http://rarediseases.info.nih.gov/gard/6202/cowden-syndrome/resources/8 Those are fairly rare disease Perhaps the above links could assist you. Seems like University of Iowa does have expertise. ...Read more

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What is pigment dispersion syndrome (krukenberg's spindle)?

What is pigment dispersion syndrome (krukenberg's spindle)?

Glaucoma risk: Pigmentary dispersion is a syndrome where pigment is liberated from the back to the iris due to chaffing and is released into the aqueous humor. The pigment gradually obstructs the drainage apparatus of the eye and in about 30% of the time, may cause enough elevation in the eye pressure to cause glaucoma (pigmentary glaucoma). Its more common in younger myopic males. Treatment is available. ...Read more

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Can 3 episodes of serotonin syndrome cause dementia years later?

Can 3 episodes of serotonin syndrome cause dementia years later?

Great Question : Serotonin syndrome is an acute toxicity due to medications which enhance serotonin in the brain. The treatment is supportive and requires stopping the offending drugs. I have not seen anything in the medical literature linking this syndrome with the development of dementia. Usually the syndrome resolves with appropriate treatment resulting in a favorable prognosis. ...Read more

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Could you explain what is neuroleptic malignant syndrome?

Complicated : "life-threatening condition that may develop anytime during therapy with neuroleptics—from a few days to many years (but 2/3 of cases occur within the 1st week). Muscular rigidity from Dopamine antagonism in the nigrostriatal pathway. Hyperthermia due to blockage of hypothalamic thermoregulation (more likely in the setting of benzodiazepine withdrawal)" from lexi drugs. ...Read more

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Are hallucinations possible with serotonin syndrome?

Are hallucinations possible with serotonin syndrome?

Possible: Serotonin syndrome can cause mental status changes such as delirium and disorientation so hallucinations may be part of the spectrum. ...Read more

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What are commonly used Serotonin Antagonists used for Serotonin Syndrome?

What are commonly used Serotonin Antagonists used for Serotonin Syndrome?

Chlorpromazine: is most commonly used..HOWEVER most "serotonin syndrome: cases are CAUSED by MEDICATIONS which should be stopped!!!!! Hope this helps Good Luck Dr Z ...Read more

Dr. Scott Mackinnon
86 doctors shared insights

Neuroleptic Malignant Syndrome (Definition)

Neuroleptic malignant syndrome is a rare, potentially life-threatening disorder usually caused by an unpredictably bad reaction to an antipsychotic drug. Typically there is muscle rigidity, fever, unstable pulse and blood pressure, mental impairments and characteristic laboratory changes. Treatment relies on stopping the drug ...Read more


Malignant (Definition)

The term “malignant” is mainly used in the context of cancer, but can also be used to describe a condition that can be acutely damaging to the body, ...Read more