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Doctor insights on: Stopping Methotrexate Suddenly

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What are withdrawal symptoms of methotrexate? Dr.Stopping me after devolving chronic bronchitis and mild asthma.

What are withdrawal symptoms of methotrexate? Dr.Stopping me after devolving chronic bronchitis and mild asthma.

No such thing: You do not get withdrawal symptoms from stopping methotrexate. The only issue is that the underlying disease it is treating can flare when it is stopped. It should be held when treating any infection. ...Read more

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Is sulfasalazine good stop gap alternative for stopping methotrexate before fathering a child? N do both these meds have negative effect on t level?

Is sulfasalazine  good stop gap alternative for stopping methotrexate before fathering a child? N do both these meds have negative effect on t level?

Sulfasalazine: Sulfasalazine can be taken safely. There may be lowered sperm counts. Methotrexate carries a risk of birth defects for a child conceived when a parent is actively taking methotrexate. ...Read more

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My RA doc recommended stopping my wkly sunday dose of 20 mg methotrexate, getting my shingles vaccine monday, resume next sun dose. Is 20 a low dose?

My RA doc recommended stopping my wkly sunday dose of 20 mg methotrexate, getting my shingles vaccine monday, resume next sun dose.  Is 20 a low dose?

Individual : The dosage is vary and will be different for different patients. Do not adjust the dose by yourself. Take this medicine only as directed by your doctor. If concern, is always good to ask your physician. ...Read more

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7yrs on prednisone & methotrexate + for "resistant ra" recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?

7yrs on prednisone & methotrexate + for "resistant ra"
recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?

Mucle testing: Inflammatory myopathy, including polymyositis, is best diagnosed and treated by a trained rheumatologist. Symptoms are proximal muscle weakness. Abnormal lab tests include elevated muscle enzymes (CPK, AST/ALT); positive antibody tests, including Jo-1; abnormal EMG/nerve conduction test; edema seen on an MRI of proximal muscles; muscle biopsy showing destruction and regeneration of muscle cells. ...Read more

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What happens if you stop taking methotrexate for your arthritis?

What happens if you stop taking methotrexate for your arthritis?

Methotrexate: You will likely have more swelling, pain, & stiffness, unless you are taking another med or dmard. ...Read more

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What happens when you stop taking methotrexate for ra?

What happens when you stop taking methotrexate for ra?

Depends on your RA -: Being controlled or not. Your symptoms might get worse. You should check with your rheumatologists as they might change it for some other medicine or if you are having side effects from the mtx, you may need some meds to counter those effects. ...Read more

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How long does methotrexate stay in your system after you stop taking drug. I am having a allergic reaction to the medicine.

How long does methotrexate stay in your system after you stop taking drug. I am having a allergic reaction to the medicine.

Rapidly leaves: 1/2 life depends on dose 3-10 hours with low dose and 8-15 hours with high dose We usually say it is out after 5 1/2 lives bt there are tissue effects too - maybe 3 weeks ...Read more

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On methotrexate to control lupus. I can never have children unless i stop this med, but nothing else controls awful symptoms. What are my options?

On methotrexate  to control lupus. I can never have children unless i stop this med, but nothing else controls awful symptoms. What are my options?

Azathioprine or plaq: Plaquenil (hydroxychloroquine) is the safest to be on for pregnancy and in severe lupus we use azathioprine as it not as toxic to a fetus. Talk to your rheumatologist to see what you are a candidate for. ...Read more

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I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it will stop?

I have stopped taking my Crohn's medication (methotrexate)i was suffering severe side effects. I'm still incredibly sick & wondering when it  will stop?

Could be Crohn's: Some of the most common side effects can be similar to symptoms of crohn's. These include mouth sores, fever, diarrhea, blood in your stools, body aches and abdominal pain. You may want to check with your doctor and make sure this is not a flare up of your disease. ...Read more

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Is it advisable to stop taking methotrexate suddenly for skin diseases?

Is it advisable to stop taking methotrexate suddenly for skin diseases?

possible flare: Possibly may cause flare, but depends on why stopping. If significant side effect, that outweighs the flare risk. ...Read more

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Had irregular cycles prior to taking methotrexate, 2 doses for ectopic. will it make cycle more irregular or cause it to stop permanently?

Had irregular cycles prior to taking methotrexate, 2 doses for ectopic. will it make cycle more irregular or cause it to stop permanently?

May or may not: it may not make you have a normal cycle. This is something you can ask your physician. You may need to do discuss this with the gynecologist. ...Read more

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Why do I need to stop methotrexate & arava (leflunomide) before alif surgery? I can't take it for 2 months after, why?

See details: Two months is an unusually long period to hold Methotrexate after surgery. Three weeks is more the usual but it is ultimately up to your surgeon. ...Read more

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After about how many weeks do you stop noticing improvement with methotrexate 4 arthritis or lupus where max improvement is reached? ~12 weeks?

After about how many weeks do you stop noticing improvement with methotrexate 4 arthritis or lupus  where max improvement is reached? ~12 weeks?

Yes: Three months is reasonable to expect the maximum response to Methotrexate at the specific dose you take. If you still have issues, consider increasing the Methotrexate dose. 25 mg weekly is generally considered to be the maximum weekly dose for the conditions you mention. ...Read more

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Since one year it take 15 mg methotrexate tablet weekly for rheumatoid arthritis so when I can stop it now my blood test is normal but still have pain?

Since one year it take 15 mg methotrexate tablet weekly for rheumatoid arthritis so when I can stop it now my blood test is normal but still have pain?

Which blood test etc: Methotrexate is a good medication for rheumatoid arthritis but it doesn't cure your arthritis - it works as long as you take it. If you still have pain, it may because of active disease (inflammation), or damage that the arthritis has already caused. You should follow up with a rheumatologist if possible. ...Read more

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I was diagnosed with an ovarian ectopic pregnancy. I was given methotrexate to help stop cell division. Will this affect future fertility?

I was diagnosed with an ovarian ectopic pregnancy. I was given methotrexate to help stop cell division. Will this affect future fertility?

No.: You are very fortunate it was caught early and could be treated without surgery. Your chances of pregnancy with two ovaries and fallopian tubes remaining will be normal. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191676/ ...Read more

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I'm on injectable methotrexate and prednisone for Dermatomyositits. I need a tooth pulled and a cleaning. Will I need to stop meds prior?

I'm on injectable methotrexate and prednisone for Dermatomyositits. I need a tooth pulled and a cleaning. Will I need to stop meds prior?

Ask your MD: Dosage and length of time on these meds are important; clotting may be reduced and adrenal glands may be suppressed. Your MD may want to do some blood work prior to an extraction. Should be no problem for a normal cleaning. ...Read more

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Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more