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Doctor insights on: Stopping Methotrexate Abruptly

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Methotrexate (Definition)

Methotrexate was originally used in the early 1950's as a treatment for cancer but was also found to be effective in many other diseases including rheumatoid arthritis and psoriasis. It has anti inflammatory and immunosuppressive properties which make it an excellent first line therapy for RA ...Read more


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What are withdrawal symptoms of methotrexate? Dr.Stopping me after devolving chronic bronchitis and mild asthma.

What are withdrawal symptoms of methotrexate? Dr.Stopping me after devolving chronic bronchitis and mild asthma.

No such thing: You do not get withdrawal symptoms from stopping methotrexate. The only issue is that the underlying disease it is treating can flare when it is stopped. It should be held when treating any infection. ...Read more

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Is sulfasalazine good stop gap alternative for stopping methotrexate before fathering a child? N do both these meds have negative effect on t level?

Is sulfasalazine  good stop gap alternative for stopping methotrexate before fathering a child? N do both these meds have negative effect on t level?

Sulfasalazine: Sulfasalazine can be taken safely. There may be lowered sperm counts. Methotrexate carries a risk of birth defects for a child conceived when a parent is actively taking methotrexate. ...Read more

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My RA doc recommended stopping my wkly sunday dose of 20 mg methotrexate, getting my shingles vaccine monday, resume next sun dose. Is 20 a low dose?

My RA doc recommended stopping my wkly sunday dose of 20 mg methotrexate, getting my shingles vaccine monday, resume next sun dose.  Is 20 a low dose?

Individual : The dosage is vary and will be different for different patients. Do not adjust the dose by yourself. Take this medicine only as directed by your doctor. If concern, is always good to ask your physician. ...Read more

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7yrs on prednisone & methotrexate + for "resistant ra" recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?

7yrs on prednisone & methotrexate + for "resistant ra"
recent elevated jo1, histone, muscle pain. How to confirm if polymyositis w/o stopping meds?

Mucle testing: Inflammatory myopathy, including polymyositis, is best diagnosed and treated by a trained rheumatologist. Symptoms are proximal muscle weakness. Abnormal lab tests include elevated muscle enzymes (CPK, AST/ALT); positive antibody tests, including Jo-1; abnormal EMG/nerve conduction test; edema seen on an MRI of proximal muscles; muscle biopsy showing destruction and regeneration of muscle cells. ...Read more

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What happens when you stop taking methotrexate for ra?

What happens when you stop taking methotrexate for ra?

Depends on your RA -: Being controlled or not. Your symptoms might get worse. You should check with your rheumatologists as they might change it for some other medicine or if you are having side effects from the mtx, you may need some meds to counter those effects. ...Read more

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What happens if you stop taking methotrexate for your arthritis?

What happens if you stop taking methotrexate for your arthritis?

Methotrexate: You will likely have more swelling, pain, & stiffness, unless you are taking another med or dmard. ...Read more

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Is it advisable to stop taking methotrexate suddenly for skin diseases?

Is it advisable to stop taking methotrexate suddenly for skin diseases?

possible flare: Possibly may cause flare, but depends on why stopping. If significant side effect, that outweighs the flare risk. ...Read more

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On methotrexate to control lupus. I can never have children unless i stop this med, but nothing else controls awful symptoms. What are my options?

On methotrexate  to control lupus. I can never have children unless i stop this med, but nothing else controls awful symptoms. What are my options?

Azathioprine or plaq: Plaquenil (hydroxychloroquine) is the safest to be on for pregnancy and in severe lupus we use azathioprine as it not as toxic to a fetus. Talk to your rheumatologist to see what you are a candidate for. ...Read more

Dr. Robert Lowe
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Rheumatrex (Definition)

Rheumatrex ...Read more