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Doctor insights on: Steven Johnson Syndrome Toxic Epidermal Necrolysis

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Please tell me about the stevens-johnson syndrome and toxic epidermal necrolysis?

Please tell me about the stevens-johnson syndrome and toxic epidermal necrolysis?

Hypersensitivity: Stevens-johnson syndrome & toxic epidermal necrolysis are thought to represent the same disease at different levels of severity. Both are immune mediated hypersensitivity reaction to drugs, infection, malignancy or unknown causes (idiopathic). The illness involves the skin & the mucous membranes. Significant & life threatening systemic involvement can occur in the course of the illness. ...Read more

Dr. Emily Altman
107 Doctors shared insights

Stevens Johnson Syndrome (Definition)

A severe type of allergic reaction to certain medications. The skin and mucus membranes such as the mouth can be effected. This is a life threatening condition that is treated in the hospital sometimes requiring care in a burn unit. A complex condition, SJS requires the care of several specialists such as a dermatologist, internist, and sometimes a surgeon ...Read more


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What are toxic epidermal necrolosys/steven johnson syndrome/erythema multiforme"?

What are toxic epidermal necrolosys/steven johnson syndrome/erythema multiforme"?

Serious Problem: Ten (toxic epidermal necrolysis) and (sjs) steven johnson syndrome are the same illness and only are separated by the percentage of body surface area involved. Erythema multiform is usually a much more limited problem. Ten/sjs can be caused by many things, and results in sloughing off of the skin in large areas and can cause severe infection, fluid loss and death. ...Read more

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How are johnson syndrome and toxic epidermal necrolysis related?

How are johnson syndrome and toxic epidermal necrolysis related?

Similar: They are similar but stevens johnson syndrome affects mucous membranes on eyes and mouth. Both are usually caused by reaction to medication but cancer and infections can be triggers also. ...Read more

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Anyone know much about toxic epidermal necrolysis?

Anyone know much about toxic epidermal necrolysis?

Hypersensitivity: Stevens-johnson syndrome & toxic epidermal necrolysis are thought to represent the same disease at different levels of severity. Both are immune mediated hypersensitivity reaction to drugs, infection, malignancy or unknown causes (idiopathic). The illness involves the skin & the mucous membranes. Significant & life threatening systemic involvement can occur in the course of the illness. ...Read more

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My grand daughter was given a toxic dose of zinc, had a severe reaction, skin peeling off entire body, is that toxic epidermal necrolysis?

My grand daughter was given a toxic dose of zinc, had a severe reaction, skin peeling off entire body, is that toxic epidermal necrolysis?

Ask the DR: Zinc toxicity causes diarrhea. There may be vomiting as well. Something very different is happening. You left out too much to get anything else. WHY WAS THIS CHILD GIVEN ANY ZINC AT ALL? What dose? How administered? Once? Or more? There are very few legitimate reasons to take zinc. ...Read more

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Is it possible to get stevens johnson syndrome twice?

Is it possible to get stevens johnson syndrome twice?

Yes, unfortunately: Patients with stevens johnson syndrome can recover and later, even years later, get it again. If the first sjs episode was caused by a known medication, the patient must avoid that medication and similar, related drugs. Some patients may have a genetic pre-disposition (inborn likelihood) to get sjs, which increases their chances of getting it a second time. ...Read more

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Can flowers affect the symptoms of stevens johnson syndrome?

Can flowers affect the symptoms of stevens johnson syndrome?

No: No; there is no data confirming any relationship between the two. ...Read more

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What's the death rate of stevens johnson syndrome here in the u.S.?

What's the death rate of stevens johnson syndrome here in the u.S.?

Depends on BSA: The death rate from steven's johnson syndrome (sjs) is dependent on the extent of skin sloughing. When body surface area (bsa) sloughing is less than 10%, the mortality rate is approximately 1-5%. However, with more extensive  sloughing (30% bsa)  the death rate is 25-35%, or higher. ...Read more

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Is methohexital associated with steven Johnson syndrome? (I know it's rarely used)

Is methohexital associated with steven Johnson syndrome? (I know it's rarely used)

Yes Rarely It Can: Since all phenobarbitals are known to sometime cause Steven Johnson Syndrome. And as Methohexital is a barbituirate it can cause Steven Johnson Syndrome in some patients but is rare ...Read more

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Can IV glutathione cause of stevens-johnson syndrome?

No: Not to my knowledge. The most common drugs associated with stevens-johnson are sulfonamides. There are numerous other drugs that are associated with it, but not glutathione. ...Read more

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Can you have a baby if you have stevens johnson syndrome before?

Should be fine: Satisfactory recovery from an episode of sjs should not automatically eliminate childbearing potential. The syndrome is variable in its intensity and may have affected the sensitive areas involved, reducing fertility, but for many it will not. A meeting with your doc to go over the issue may provide more specific answers to your individual case. ...Read more

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Is it possible to get steven johnson syndrome from one antibiotic?

Is it possible to get steven johnson syndrome from one antibiotic?

Yes: This is a hypersensitvity, allergic type reaction to the ingestion of pharmacologics and sometimes other chemicals. The most common causes of this fortunately rare condition are antibiotic, particular those with a sulfa chemical configuration. ...Read more

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Can prilosec cause stevens-johnson syndrome?

Can prilosec cause stevens-johnson syndrome?

Probably: Nearly any drug can cause Stevens Johnson although the mechanism remains unclear. However certain drugs (sulfa for example) are more likely to cause it than others. I suspect that the probability of Prilosec causing it is low but not impossible. ...Read more

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Is stevens-johnson syndrome be a side effect of ibuprophen?

Maybe: There apparently have been cases of sjs in people taking ibuprofen. It is very rare if it does occur. ...Read more

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Have any benzodiazepines been associated with steven Johnson syndrome at all?

Have any benzodiazepines been associated with steven Johnson syndrome at all?

Very rare - BUT: Apparently yes. However, I don't know if the benzodiazapine was casuative. See: https://www. Ncbi. Nlm. Nih. Gov/pmc/articles/PMC3612312/ ...Read more

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If you have steven johnson syndrome on vagina an it peels does that mean its going away? If not what does that mean?!

If you have steven johnson syndrome on vagina an it peels does that mean its going away? If not what does that mean?!

Steven Johnson's: Syndrome is a rare, full body allergic reaction rendering a person very ill. It would not be localized to the vagina. Have u been seen by a physician? ...Read more

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Does stevens johnson syndrome start after tonsil surgery?

There is no: Direct relationship. Stephen johnson syndrome is a severe, life threatening immune reaction that is the body's response to exposure to a foreign substance. ...Read more

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Is there an incubation period for stevens-johnson syndrome?

No: Incubation period refers to the duration after which a person is transmitted a pathogen (i.e. Virus or bacteria) until the infection is apparent. Stevens-johnson syndrome (sjs) is not an infection and therefore there is no incubation period. Very rarely sjs can result from an individuals 'reaction' to an infection. More often sjs may result from antibiotics used to treat infections. ...Read more

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What's the best treatment to get rid of stevens johnson syndrome?

What's the best treatment to get rid of stevens johnson syndrome?

Steven Johnson Syndr: Steven johnson syndrome is a serious condition and it involves skin and mucous membranes and other systems may get involved. It needs to be treated in an intensive care unit with large doses of steroids and IV fluids and other supportive measures and inspite of the treatment it can be fatal. So to answer your question you don't get rid of it but it has to be treated by doctors in the hospital. ...Read more

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Out of curiosity, has aspirin been linked to Stevens-Johnson syndrome?

Rarely, but yes: Nearly all of the non-selective NSAIDS have been implicated in Stevens-Johnson syndrome. They are cyclooxygenase inhibitors. But these reactions are very uncommon. 80% of this syndrome is caused by drugs and consists of a red to purple skin eruption progressing to bullae and necrosis of skin and sometimes mucous membrane. Treatment is with corticosteroids but long term use can aggravate. ...Read more

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Is there and association between lupus and histoplasmosis or lupus and steven johnson syndrome?

Is there and association between lupus and histoplasmosis or lupus and steven johnson syndrome?

Indirect: Histoplasmosis can complicate lupus because of reduced resistance to infection. Steven johnson syndrome is more likely to be due to medications used to treat lupus than to the lupus itself. ...Read more

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A doctor recently gave me a possible diagnosis of stevens johnson syndrome. Should I get a second opinion?

SJ syndrome: Stevens johnson is a potential life threatening disease that occurs as a reaction to a medication. If this is what your doctor says, you need to be under very close medical observation. ...Read more

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I was wondering what reaction metrogel would cause and could it cause Steven Johnson syndrome or dizziness?

I was wondering what reaction metrogel would cause and could it cause Steven Johnson syndrome or dizziness?

None of those: Metronidazole gel, somewhat useful for control of rosacea, will not cause dizziness. If you have Stevens Johnson syndrome it is a SERIOUS condition often caused by a sensitivity to a sulfonamide or other medication. In my area it is a favorite diagnosis by ER physicians who seldom get it right. A topical med is extremely unlikely to cause anything like this. ...Read more

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Got oral thrush, given nystan, I am not taking it, it can cause steven-johnson syndrome. Why anyone would use this I do not know?

Got oral thrush, given nystan, I am not taking it, it can cause steven-johnson syndrome. Why anyone would use this I do not know?

Very rare: Nystatin is considered a safe drug. There has only been one reported case in the medical literature of stevens-johnson syndrome from nystatin. That was not a controlled study and has not been verified in any other way. Many other common drugs *can* cause s-j syndrome, but it is still very rare. ...Read more

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I'm considering iv glutathione for skin brightening. Is there a risk for steven johnson syndrome with the drug? I've had sjs from taking lamotrigine.

I'm considering iv glutathione for skin brightening. Is there a risk for steven johnson syndrome with the drug? I've had sjs from taking lamotrigine.

No: It's a naturally-occurring substance. I'd urge you, though, not to do this. It may interfere slightly with production of melanin, but the result may not look natural. Here in the US, trying to alter one's skin color is considered the height of ignorance, and we do still set world trends. Taking anything by vein creates an infection risk. Embrace your own genetics and look good by staying fit. ...Read more

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I was given zithromax and I think I had a steven johnson syndrome reaction the docs changed medicine and sent me home is this an ok or should I go back?

Depends on symptoms: If your physician is truly concerned about either Stevens-Johnson syndrome or toxic epidermal necrolysis you should be admitted to the hospital. Early recognition and immediate withdrawal of any potentially causative agents are critical first steps in management. If the diagnosis is unclear, then you should be seen by your primary doctor immediately so that the correct diagnosis can be made. ...Read more

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How can I get stronger after I suffer from steven johnson syndrome?

Time: You are most likely very lucky to be alive. This is a serious issue and will take time. Time, avoiding the med that caused this, rest, nutrition and time. This should help out if your underlying health is ok. ...Read more