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Doctor insights on: Stage 3 Colon Cancer Adjuvant Therapy

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3 cycles of chemotherapy so far for metastic colon cancer shows therapy working , if 2 cycles are missed due to ill health , will cancer start growing agsin ?

3 cycles of chemotherapy so far for metastic colon cancer shows therapy working , if 2 cycles are missed due to ill health , will cancer start growing agsin ?

No: If 3 cycles of chemo given and well tolerated, evaluation might show stability or regression if drugs working. If missing 2 cycles, this will not allow further regression while off medication, but if resumed a further response may be defined. Most combo drugs for colon cancer may show a termporary response but not cure. The newer combinations with Immunochemotherapy more effective. ...Read more

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Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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How effective is neoadjuvant therapy for treating colon cancer?

How effective is neoadjuvant therapy for treating colon cancer?

Partially: Chemotherapy in all of its forms is only partially helpful in improving the survival of colon cancer. When there is an effective neoadjuvant response the remaining lesion can be successfully resected. complete surgical extirpation is the needed result. As immunochemo becomes more effective then the combination with surgery will even produce better results. ...Read more

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What is radiation therapy treatment for colon cancer?

What is radiation therapy treatment for colon cancer?

Energy beams: For certain types of colorectal cancer, energy beams are focused in the cancerous area. These beams are designed to kill cancer cells and decrease the chance of the tumor growing back. Depending on the situation, radiation can be used either before an operation or after an operation. ...Read more

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How effective is radiation therapy for treating colon cancer?

How effective is radiation therapy for treating colon cancer?

Partially effective: The best approach for colon cancer is resection. If lesion is large such as one in the rectosigmoid, then RT plus chemo can be employed to reduce the lesion for resection. While the end effect minimizes local recurrence, it does not alter overall survival. ...Read more

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Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Which chemo therapy is most effective for KRAS mutant metastic colon cancer ?

Same drugs as other: Same chemotherapy drugs are used for treating both types of colon cancer. The only difference is lack of benefit from EGFR inhibitors(Cetuximab and Panitumumab). Avastin (bevacizumab) also works in both types. I trust that you know there are 3 chemo drugs that are widely used(5FU or Capecitabine, Irinotecan and Oxaliplatin) ...Read more

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Is it possible to get radiation therapy for colon cancer?

Is it possible to get radiation therapy for colon cancer?

Yes: Radiation is standard treatment for rectal cancers which have not spread and is used in combination with chemotherapy. For pure colon cancers, radiation is used sometimes in special situations (e.g. Cancer involving nearby critical organ or causing pain/ bleeding). The main therapies for colon cancer though are surgery and chemotherapy. ...Read more

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Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed ?

Can any targeted therapies or other drugs help with metastic colon cancer when Xeloda (capecitabine) n irinotecan has failed ?

Yes: Target agents that have activity either as single agent or as combination for recurrent or refractory metastatic colon cancer as a second line include: Avastin (bevacizumab) or Cetuximab/Panitumumab (if k-ras, n-ras, b-raf are wide type) or Regorafenib (inhibitor of angiogenic receptor) or aflibercept. FOLFOX may be effective too after irinotecan has failed. Clinical trials are aslo available. ...Read more

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Can radiation therapy be delivered to a colon cancer from a device inside a patient?

Can radiation therapy be delivered to a colon cancer from a device inside a patient?

Yes: In some universities and major institutions there are dedicated machines for intraoperative radiation given to an area of concern that the surgeon could not resect and this device is aimed inside the abdomen to give the radiation. This is not common or widely available and outside machines are more readily available. ...Read more

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Dr. Eric Kaplan
923 doctors shared insights

Colon Cancer (Definition)

Final few yards of your intestine, between the terminal ileum (small bowell) and rectum. It squeezes water and solidifies waste to stool. It is subject to outpouching (divertics) polyps, and these can become cancers. The cells are abnormal, invade into the muscle and travel ...Read more


Dr. Adam Lewis
1 doctor shared a insight

Colon (Definition)

The colon is another term for the large intestine. This is the final portion of the digestive system, responsible for absorbing water and storing stool before evacuation. It is divided into sections described as cecum; ascending, transverse, descending and ...Read more