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Doctor insights on: St Johns Wort With Sertraline

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Can I start Zoloft (sertraline) 24 hours after taking st john wort?

Can I start Zoloft (sertraline) 24 hours after taking st john wort?

I would encourage: You not to take both these compounds together. I usually recommend taking an antidepressant over st johns' wort because in this country, herbals are not well regulated. In europe - herbals are treated like other medications ; are regulated. ...Read more

Dr. Heidi Fowler
1,094 Doctors shared insights

Sertraline (Definition)

Also called zoloft, (sertraline) is one of selective serotonin reuptake inhibitors, with antidepressant/anti-anxiety actions. May cause headaches, nausea & ...Read more


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Does Zoloft (sertraline) cause weight gain? Are there any interactions with Zoloft (sertraline) and st. John's wort?

Does Zoloft (sertraline) cause weight gain? Are there any interactions with Zoloft (sertraline) and st. John's wort?

Probaly Not: There is no strong association between zoloft (sertraline) and weight gain but depression can cause loss of appetite and treatment may cause it to return.
Do not take st. Johns wort, its affects are additive to zoloft (sertraline) and might cause a condition called serotonin syndrome or neuroleptic malignant syndrome. ...Read more

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Can I drink chamomile tea with Zoloft (sertraline)? Is there an interaction? I know St. John's Wort is off limits :) Is chamomile safe?

Can I drink chamomile tea with Zoloft (sertraline)? Is there an interaction? I know St. John's Wort is off limits :) Is chamomile safe?

Yes it is: The St. John's is more of a theoretical. Although it (but not chamomile) lowers liver metabolism of drug, it is not a strong blocker of liver metabolism, and the safety margin of Zoloft (sertraline) is quite high (double the amount is still safe in most). ...Read more

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Natural supplaments like sam-e, 5-htp, st johns wort are good for depress, anx & mood. Can all be taken, or just 1 or 2? I'm not on prescrip meds.

Natural supplaments like sam-e, 5-htp, st johns wort are good for depress, anx & mood. Can all be taken, or just 1 or 2? I'm not on prescrip meds.

Perhaps but caution: Each of these has been shown to work as well as prescription antidepressants, but just as I would not start someone on 3 meds at the same time I would not start all of these at once; it will probably not be necessary and you could wind up with too much serotonin, which can be toxic. My favorite of these is 5-htp, usually 200-300 mg, esp. Beneficial if you have insomnia &/or anxiety. See my comment. ...Read more

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What happens if I take st johns wort?

What happens if I take st johns wort?

Potent herbs: This can elevate the mood much like a synthetic selective serotonin reuptake inhibitor, and some say it's a good adjunct to the process of learning how to maintain a happy, productive attitude through insight and practice. It's also likely to sensitize your skin to sunlight and may make your hands tingly. Always let your physicain know if you take it. ...Read more

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What amount st. Johns wort is too much?

No good studies yet: Different studies have examined different doses, and different companies put different recommendations on their bottles; you've probably noticed. The stuff seems quite safe used judiciously, and some people do wel on higher doses, but it's very dangerous combined with prescription SSRI's, and is a famous sun-sensitizer. ...Read more

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Is Sam-e better than St. Johns Wort, or can I take them both at the same time?

Is Sam-e better than St. Johns Wort, or can I take them both at the same time?

See a doc: If you are so depressed that you are thinking of this, or mixing it with St. John's wort, you are much better off getting a med whose dosage is known, its production for potency per mg is regulated, & whose side effects are well studied and understood. If you do not wish to see a doctor, consider non-medical ways to treat depression which are known to help. Proper diet, regular exercise, therapy ...Read more

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Could st. Johns wort effect my blood sugar?

Could st. Johns wort effect my blood sugar?

Yes, Sugar effects: Extensive research supports the safe use of St. John's wort for a short duration ( ...Read more

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Can I take losec (omeprazole) and st johns wort at the same time?

Can I take losec (omeprazole) and st johns wort at the same time?

Yes, but...: St. John's wort will speed up the rate that your liver breaks down losec (omeprazole). So combining both medications will reduce the effectiveness of losec (omeprazole). ...Read more

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Does St. Johns wort decrease the effect of the morning after pill?

Does St. Johns wort decrease the effect of the morning after pill?

Nonconclusive: Some studies have shown that St John's wort speeds up the metabolism of estrogen and progesterone. But others do not confirm that finding. Also the dosage of St Johns Wort is not standardized. So there is no way of telling what effect it will have. ...Read more

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I take alprazolam 0.50 when needed to (usually 2 to 3 times a month). Are there none interactions with that drug and st johns wort or 5-htp daily?

I take alprazolam 0.50 when needed to (usually 2 to 3 times a month). Are there none interactions with that drug and st johns wort or 5-htp daily?

St. John's Wort may: Decrease effects of Alprazolam; may interact with 5-HTP (5-hydroxytryptophan) to increase risk of a rare but serious condition called serotonin syndrome; and may interact with some foods. These interactions may mimic anxiety/panic attacks. Consult prescriber regarding all medications and supplements to determine what is best for your situation. Best regards for good health and well-being. ...Read more

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What is the correct dosage of st johns wort?

What is the correct dosage of st johns wort?

St. Johns Wort: St. John's wort is a natural, herbal medicine that is reported to treat depression. The psychiatric hx. Of this plant goes all the way back to ancient Greece where it was used to treat “nervous conditions”. Over the years it’s been reported to help PMS, menopause, Usual dosage of St. John's wort is 300 mg, 3x a day. But, since herbal supplements are not regulated by the FDA, the dose may vary. ...Read more

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Can GABA and st johns wort be combined?

GABA: No direct harmful effect that I am aware of. ...Read more

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Can I combine St. Johns Wort tea and Rhodiola Rosea?

Can I combine St. Johns Wort tea and Rhodiola Rosea?

Not advisable: St John's Wort is a flowering plant of the species Hypericum perforatum. It contains a substance that acts like an SSRI, similar to Prozac or Zoloft (sertraline).

SJW has the same problems that all herbal or "natural" compounds have - the concentration of the active ingredient is unknown, and such compounds are often heavily contaminated with aspirin-like compounds, or worse (e.g., heavy metals). ...Read more

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Docs, can I take st johns wort if I'm already on tildiem?

Docs, can I take st johns wort if I'm already on tildiem?

Interaction: Using them together can cause your diltiazem level to decrease. Discuss with your pcp and if your BP is well controlled MAYBE you can add a little st johns wort and see if it goes up. Another option would be to choose an antidepressant medication that has no interaction. St johns wort can be effective but its hard to know if you are getting the same dose each time... ...Read more

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Is I t okay to take st. Johns wort with 25mg of xanax (alprazolam)?

Interaction: I think you mean 0.25mg of xanax (alprazolam). Anyways, no, that would not be a good idea. St. John's wort is notorious for several interactions with prescription medications and otcs. It may cause xanax (alprazolam) to work less effectively. ...Read more

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Can st. Johns wort be taken with one dose of. 025mg xanax (alprazolam)?

Can st. Johns wort be taken with one dose of. 025mg xanax (alprazolam)?

Would not use: St. John's wort can induce the liver enzymes needed to metabolize xanax (alprazolam) and prozac, possibly making them less effective. Why would you want to take st. John's wort when you're already on Prozac & xanax (alprazolam) (according to your additional patient information)? ...Read more

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Can you tell me how hyperforin (from st johns wort) inhibit cyp3a4 enzymes?

Can you tell me how hyperforin (from st johns wort) inhibit cyp3a4 enzymes?

Unsure: I am unsure if the mechanism of medication-induced oxidative enzyme inhibition is known. A pharmacologist might know. It is my understanding, however, that it is time-limited, meaning the enzyme returns to normal levels once the medication is no longer taken.
...Read more

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I meant to say can st. Johns wort be taken with one dose of 0.25mg of xanax (alprazolam)?

I meant to say can st. Johns wort be taken with one dose of 0.25mg of xanax (alprazolam)?

Would not use: St. John's wort can induce the liver enzymes needed to metabolize xanax (alprazolam) and prozac, possibly making them less effective. Why would you want to take st. John's wort when you're already on Prozac & xanax (alprazolam) (according to your additional patient information)? Other studies show that st. John's wort has similar serotonin reuptake-inhibiting action to prozac, leading to adverse effects. ...Read more

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Does st. Johns wort elevate TSH levels?

Does st. Johns wort elevate TSH levels?

Equivocal findings: There was a small (37 patients) study suggesting that st john's wort (sjw) might elevate tsh. Http://tinyurl. Com/lvjyayl in this study, 4/37 patients with elevated TSH had taken sjw in the 3-6 month period before TSH was measured, but only 2/37 of those with normal TSH had taken sjw in the same time period. Some question the data analysis of this small difference. Http://tinyurl. Com/mw5zhcu. ...Read more

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Can I use st johns wort instead of antidepressants?

Can I use st johns wort instead of antidepressants?

St John's wort: "A 2009 systematic review of 29 international studies suggested that St. John’s wort may be better than a placebo (an inactive substance that appears identical to the study substance) and as effective as standard prescription antidepressants for major depression of mild to moderate severity." REF: https://nccih. Nih. Gov/health/stjohnswort/sjw-and-depression. Htm. However, many studies are from ...Read more

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Is it safe to take st johns wort pills while breastfeeding?

Is it safe to take st johns wort pills while breastfeeding?

Should be okay...: Among the infants nursed by mothers taking st. John’s wort, there were reports of adverse events, including colic, drowsines, & lethargy. Some reports in animals suggest that st. John’s wort may reduce milk production. The jury is still out and most experts would allow breastfeeding while taking st. Johns wort with close monitoring for the above issues. ...Read more

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Can st johns wort cause a false positive on a drug screening?

Can st johns wort cause a false positive on a drug screening?

No: St. John's wort can affect certain of the liver's metabolic pathways, but would not cause a false positive on a urine drug screen. If there's any question about a substance appearing on the initial screen, confirmatory tests are performed anyway. ...Read more

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Trying an herbal antidepresant like st. Johns' wort, how does it work?

Trying an herbal antidepresant like st. Johns' wort, how does it work?

Not personally: I have not taken st. John's wort, but good research shows it's effective for mild to moderate depression. Results depend also on product used, including standardization and reliability of contents. Http://www. Consumerlab. Com/ is a very helpful site to learn about specific products which have been tested. I have been treated homeopathically for a bad ptsd, and the results have been profound. ...Read more

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I am taking a low dose of St Johns wort daily (less than 400mg). I have a fever. Can I take any analgesics?

I am taking a low dose of St Johns wort daily (less than 400mg). I have a fever. Can I take any analgesics?

Depression: If St John's wort works for your depression, please continue taking it as usual. Fever may be caused by some infection or inflammation, and needs to be evaluated and treated accordingly. Analgesics won't interfere with the effect of St John's wort. ...Read more

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Took 20mg of Prozac (fluoxetine) for 8 mos. Been off for two weeks. Can I now take st. Johns wort. Didn't like side effects of prozac (fluoxetine)?

Took 20mg of Prozac (fluoxetine) for 8 mos. Been off for two weeks. Can I now take st. Johns wort. Didn't like side effects of prozac (fluoxetine)?

Probably: Prozac (fluoxetine) will stay in your system for 4-6 wks & st johns is a weak maoi which theoretically could b a problem but st. John's is so weak I've had pts who've taken it with their antidepressants including Prozac (fluoxetine) with no problems. ...Read more

Dr. Heidi Fowler
1,048 Doctors shared insights

Zoloft (Definition)

Zoloft is a serotonin reuptake blocker which is a kind of ...Read more