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Doctor insights on: Ssris And Weight Gain

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Dr. Michael Rothman
1,333 doctors shared insights

Weight Gain (Definition)

Weight gain is an increase in body weight. This can be a result of increases to muscle mass, increases in body fat, or increases in body fluids like water. Occasionally, weight gain can be a symptom of ...Read more


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Why do some ssris cause weight gain and others don't? Do they alter metabolism or calorie absorbtion different?

Why do some ssris cause weight gain and others don't? Do they alter metabolism or calorie absorbtion different?

Hunger in head: Ssri's are a class of antidepressants which also trigger a hunger pathway in the brain. Some bariatricians are looking forward to using wellbutrin (bupropion) and Naltrexone for patients (after approved by fda. This new combination would directly reduce those same hunger hormones. ...Read more

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How can ssris cause both weight gain or weight loss in some people?

How can ssris cause both weight gain or weight loss in some people?

Good question: Ssris work by blocking the reuptake of serotonin from neural synapses, making serotonin more available for all different types of serotonin receptors. Some of those receptors impact appetites, which is one of the reasons that decrease in sexual appetite is a common side effect. Another serotonin receptor impacts the sense of satiety. Individual response depends on relative contributions of these. ...Read more

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Why do all antidepressants (ssri's) cause severe weight gain and qt prolongation?

Why do all antidepressants (ssri's)  cause severe weight gain and qt prolongation?

All?: That is a little bit of an exaggeration i feel although there are frequent side effects with most pharmacotherapies and your frustration with this is palpable. I would offer you the perspective that maybe not all antidepressants cause weight gain and some do not consistently prolong the qtc interval. In fact, there is some research to suggest that bupropion causes shortening of the qtc interval. ...Read more

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What is the best ssri to use to avoid weight gain and maintain my personality yet help negative intrusive thoughts from ocd?.

What is the best ssri to use to avoid weight gain and maintain my personality  yet help negative intrusive thoughts from ocd?.

Talk w/your doctor: Talk with your doctor about this, but Lexapro (escitalopram) is probably the most weight-neutral of the ssri's. Zoloft maybe, also (though i've seen weight gain with it as well.). ...Read more

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I was wondering about ssris. Why do some cause weight gain and others don't? They both affect serotonin. Does it affect metabolism? Thyroid?

I was wondering about ssris. Why do some cause weight gain and others don't? They both affect serotonin. Does it affect metabolism? Thyroid?

It depends : Different ssris have different chemical structures can affect not only the serotonin reuptake but other hormonal patterns including the thyroid function norepinephrine uptake Dopamine uptake or other hormones in the body. Hence different ssris effect weight differently. Zoloft and Effexor (venlafaxine) are usually weight neutral and Paxil and prozac's cause some weight gain. ...Read more

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What type of ssri is has been know best to not cause weight gain any sexual side effects in women?

What type of ssri is has been know best to not cause weight gain any sexual side effects in women?

All SSRI can cause t: However , lexapro, can have the least side. Effect among the ssri.Regarding sexual side effect usually i tell my patient if u know u when u will be having sex stop the medication one day before . Another option to add wellbutrin (bupropion) to the ssri ... ...Read more

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Looking to get on an antidepressant. Out of the ssri family which one has been known to not cause weight gain?

Looking to get on an antidepressant. Out of the ssri family which one has been known to not cause weight gain?

All might: Especially in long (>6mths) term use all have been known to, but Wellbutrin, Effexor (venlafaxine) and Serzone are less so and Zoloft is a bit less than the most reported - Paxil is the worst by reports. CBT therapy has no side effects and can help you minimize or avoid drugs - consider it as an adjunct so you can avoid long term use. Best! ...Read more

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Last week started shifting from ssri (cipralex) to inositol due to weight gain but started to feel anxious and negative thoughts attacked is normal?

Last week started shifting  from ssri  (cipralex) to inositol due to weight gain but started to feel anxious and negative thoughts attacked is normal?

Not normal but...: Inositol can be helpful for anxiety but research shows you need a dose of 12 grams a day. Ssri withdrawal can cause your current symptoms- best to taper slowly with help from your doc. Inositol may not be enough- other treatments like 5-htp, st. John's wort, holy basil, ashwagandha, b vits., meditation & homeopathy might help.It's best to work with a holistic doctor knowledgeable in these matters. ...Read more

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What class is pristiq (desvenlafaxine) in ssri's? And isnt pristiq (desvenlafaxine) a fairly new depression med.Nd can it cause weight gain?

What class is pristiq (desvenlafaxine) in ssri's? And isnt pristiq (desvenlafaxine) a fairly new depression med.Nd can it cause weight gain?

Pristiq (desvenlafaxine): In a nutshell, Pristiq (desvenlafaxine) is a revamped version of Effexor and Effexor xr, although the delivery system is different. Pristiq (desvenlafaxine) is a seretonin norephinepine reuptake inhibitor (snri). Of those in its class (remeron, cymbalta), Pristiq (desvenlafaxine) has not neen shown to cause weight gain. It also does does not interfere with sexual libido or ability to reach climax. Drawback is its discontinuation syndrome if stop s. ...Read more

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When Zoloft and Lexapro loose their efficacy and one cannot take Paxil (paroxetine) because of weight gain what other ssri possibilities are there for anx and dep ?

When Zoloft and Lexapro loose their efficacy and one cannot take Paxil (paroxetine) because of weight gain what other ssri possibilities are there for anx and dep
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SNRIs: There are many possibilities. SNRIs which are cousins of SSRIs w/ a norepinephrine component can be equally or more efficacious than SSRIs w/ sometimes less side effects such as weight gain & sexual dysfunction - would suggest evaluation w/ your Physician to discuss appropriate options ...Read more

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Does Tramadol cause weight gain if SSRI's have done so in the past? Will the risk of seizures increase if I am also taking 200-300mg/Buproprion?

Does Tramadol cause weight gain if SSRI's have done so in the past?  Will the risk of seizures increase if I am also taking 200-300mg/Buproprion?

No and yes: No, tramadol should not cause any wt gain, but yes - taking this with bupropion may increase your risk of seizures especially at higher doses. A history of seizures would be a contraindication for using buproprron in most cases. ...Read more

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Is weight gain and lethargy often associated with Zoloft (sertraline) and is sweating very prevalent with this ssri?

Is weight gain and lethargy often associated with Zoloft (sertraline) and is sweating very prevalent with this ssri?

Possibly...: Some people may experience weight gain and/or lethargy on zoloft (sertraline) but i would say in general most people tolerate zoloft (sertraline) pretty well. Sweating is a possible side effect of every antidepressant; for some reason an individual will sweat excessively with one med but not with another-- it can happen with any one of them. It's pretty weird! ...Read more

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Hw to weight gain?

Hw to weight gain?

Eat healthy high: calorie foods. Eat 6 meals/day. Work on strength training to build large muscle groups. Workout w heavier weights w fewer repetitions. Sleep at least 8 to 9 hrs/night. Hydrate well w water. Foods to help w healthy weight gain: almonds, cashews, pecans, sunflower seeds, flax seeds, walnuts, hummus, Avocados, granola, trail mix, dried fruits, extra virgin olive oil, canola oil, protein shakes, > ...Read more

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What causes weight gain?

What causes weight gain?

Many factors: There are several reasons for weight gain. It can be as simple as eating too many calories, or eating the wrong calories, or not getting enough exercise. You will gain weight when you take in more calories than your body burns each day. There are also medical conditions and hormone imbalances which cause weight gain, and medications with side effects of weight gain. ...Read more

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Dr. Carlos Satulovsky
588 doctors shared insights

Ssri (Definition)

A class of drugs, such as fluoxetine or sertraline, that inhibit the uptake of serotonin and are primarily used in the treatment of depression ...Read more