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Doctor insights on: Spleen Diseases Splenomegaly

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What is the connection between an enlarged spleen and anemia?

What is the connection between an enlarged spleen and anemia?

Hemolysis: Enlarged spleen is usually seen in anemia whenthe rbc is fragile. Many disorders can cause this. Fragile rbcs can then be broken down in the spleen (a process referred to as hemolysis). This causes different levels of anemia and an enlarged spleen. Often jaundice can be seen as well. ...Read more

Dr. Linda Callaghan
79 doctors shared insights

Large Spleen (Definition)

Splenomegaly is an enlargement of the spleen, which usually occurs when the spleen becomes filled with red blood cells. This can happen in liver disease, where blood backs up into the spleen, or it can occur in conditions where defects in blood cells cause them to become trapped in the spleen. Infectious mononucleosis and other viral infections can cause ...Read more


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Can Splenic Marginal Zone Lymphoma ever present with recurrent, interrmitent splenomegaly, where spleen is large may times, and other times normal?

No.: The spleen doesn't fluctuate in size like that, but I have seen the skill of various physicians differ significantly, so that an hour after a colleague feels no splenomegaly, I feel significant splenomegaly. ...Read more

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Us normal except-"mild heterogeneity to the spleen with borderline splenomegaly.Cannot rule out lymphomatous involvement." what does this indicate?

Us normal except-"mild heterogeneity to the spleen with borderline splenomegaly.Cannot rule out lymphomatous involvement." what does this indicate?

Funky spleen: Means that the spleen is slightly enlarged and not uniform-looking but the radiologist cannot say anything else based on that test. Could be many things including (but not exclusively) a lymphoma. Your doctor may need to do additional tests depending on the clinical picture and the reason for which he/she ordered the us to begin with. Talk to him/her about its implications. Best to you. ...Read more

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Had mono 9 yrs ago and splenomegaly for 2 yrs after. Now am having same spleen discomfort. Do i need to see my doc? (savella (milnacipran) 100mg/day past 3wks?)

Whatever is causing: The discomfort now is not likely to be the same cause as 9 years ago. There are a number of causes of mono-like illnesses and this could perhaps be say CMV instead of ebv. ...Read more

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3 yr old TPN dependent for 2 yrs. She has splenomegaly (measured 8.9) alt/ast looks great. Can TPN cause spleen enlargement w/out affecting liver?

3 yr old TPN dependent for 2 yrs. She has splenomegaly (measured 8.9) alt/ast looks great. Can TPN cause spleen enlargement w/out affecting liver?

Doubtful, but: I have never seen TPN cause isolated splenomegaly without some involvement of the liver, but i would defer the final answer to a peds GI doc. However, i would be more concerned that whatever underlying condition that is causing her to be TPN dependent and not able to use her gut is contributing to her splenomegaly, and not the TPN itself. ...Read more

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CT showed splenomegaly. Blood work had high RDW, low creatinine, and low MCH (anemia?); other CBC normal. How could anemia be related to spleen?

CT showed splenomegaly. Blood work had high RDW, low creatinine, and low MCH (anemia?); other CBC normal. How could anemia be related to spleen?

Splenomegaly: It isn't clear from what you say whether your hemoglobin itself is truly abnormal or whether just the RDW and MCH are altered. These in themselves do not define anemia. A large spleen may be related to trapping altered red cells, or actually making more blood (extramedullary hemopoiesis.) Often a high RDW means that there is increased production of immature red cells after destruction in spleen ...Read more

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Does a low hemoglobin and hematocrit means you have a large spleen my my hbg was Range 11.3 11.5-15.0and my hematocrit was 34.6 Range36.0-50.0?

Does a low hemoglobin and hematocrit means you have a large spleen my my hbg was Range 11.3 11.5-15.0and my hematocrit was 34.6 Range36.0-50.0?

Many causes for it: Low Hemoglobin(Hb) commonly known as Anemia can be caused by many different reasons....enlarged spleen is present in some such conditions but it is uncommon, as most anemia is from blood loss or from deficiency of iron. You need a good doctor to investigate the cause and inform you about it so that you do not have to keep running to different doctors. ...Read more

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What blood rest detects large spleen?

What blood rest detects large spleen?

No blood test: Only physical examination and imaging studies such as ultrasound or ct could diagnose an enlarged spleen. ...Read more

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Help please? I've got a large spleen and high WBC what could be wrong?

Help please? I've got a large spleen and high WBC what could be wrong?

Doctor: You definitely need to consult your physician or a hematologist. Even though the signs you report are not highly specific, they are worrisome and may be associated with serious disease including infections but also leukemia. Please consult with your doctor immediately. ...Read more

Dr. Neigatha Graney
17 doctors shared insights

Spleen Diseases (Definition)

A spleen disease is a condition in which a person has a disorder of the spleen, usually an enlarged spleen due to a blood cell disorder or an infection. Another spleen problem is a ruptured spleen, due to trauma. The spleen is an organ that lies next to the stomach, with functions such as removing old red blood cells, storing blood ...Read more


Dr. James Dukelow
194 doctors shared insights

Enlarged Spleen (Definition)

An enlarged spleen is a clinical finding in which the spleen is larger than in a normal, healthy person. This can occur with infections, diseases of ...Read more