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Doctor insights on: Spironolactone Drug Interactions

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Dr. Anita Deswal
405 doctors shared insights

Spironolactone (Definition)

Treats fluid retention (edema) in patients with congestive heart failure, liver cirrhosis, or nephrotic syndrome. Also treats high blood pressure, heart failure, and low blood potassium (hypokalemia). This medicine is ...Read more


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Can 25 mg spironolactone be taken with 5 mg amlodipine same time or do you space them a part. Any interactions?

Can 25 mg spironolactone  be taken with 5 mg amlodipine same time or do you space them a part. Any interactions?

Either way: They can be taken together or separate. Spironolactone is generally taken in the morning because of its diuretic effect. Amlodipine can be taken morning or night. ...Read more

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How often does the drug spironolactone cause breast enlargement in women?

How often does the drug spironolactone cause breast enlargement in women?

Not in women: Spironolactone (aldactone) is an antiandrogen, so it does have an effect to decrease testoterone, and there is an indirect estrogenic effect - which can cause breast enlargement (gynecomastia) and tenderness in men. Breast tenderness is occasionally reported in women, but this is unusual. ...Read more

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If spironolactone (for acne) is androgen blocker - how does this not have any interaction with androgenic progestin such as levonorgestrel/Mirena?

It could: The circulating levels of Progesterone secreted by Mirena (levonorgestrel) are very low making androgen side effects possible but uncommon. Spironolactone would decrease the androgenic effects if they were to be present although a doctor would not typically treat Mirena (levonorgestrel) side effects this way. If I were the physician treating someone with androgenic side effects of Mirena (levonorgestrel) I would just change birth control methods ...Read more

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Can I take aldactone (spironolactone) w/ another drug to lower my potassium levels?And both work to do their job?Aldactone (spironolactone) made me have high pot.But I want to take it

Can I take aldactone (spironolactone) w/ another drug to lower my potassium levels?And both work to do their job?Aldactone (spironolactone) made me have high pot.But I want to take it

It depends: it depends on why you're taking spironolactone (Aldactone). Suggest low potassium diet - especially avoid tomatoes, potatoes, bananas and orange juice (or V8 juice). Some people take an additional diuretic to lower potassium but these drugs have other side effects. ...Read more

Dr. Ronald Krauser
1 doctor shared a insight

Drug Interaction (Definition)

When the combination of two agents cause an effect, intended or unintended, that would not have otherwise ...Read more


Dr. Ravi Chand
223 doctors shared insights

Aldactone (Definition)

Aldactone is a potassium-sparing agent which is a kind of water pill or diuretic (heart ...Read more