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Doctor insights on: Spironolactone Drug Interactions

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Dr. Anita Deswal
418 Doctors shared insights

Spironolactone (Definition)

Treats fluid retention (edema) in patients with congestive heart failure, liver cirrhosis, or nephrotic syndrome. Also treats high blood pressure, heart failure, and low blood potassium (hypokalemia). This medicine is ...Read more


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Can 25 mg spironolactone be taken with 5 mg amlodipine same time or do you space them a part. Any interactions?

Can 25 mg spironolactone be taken with 5 mg amlodipine same time or do you space them a part. Any interactions?

Either way: They can be taken together or separate. Spironolactone is generally taken in the morning because of its diuretic effect. Amlodipine can be taken morning or night. ...Read more

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I am transgender and I do not want SRS, but I am interested in chemical castration. I am taking Estradiol and Spironolactone now. What other drugs wou?

I am transgender and I do not want SRS, but I am interested in chemical castration. I am taking Estradiol and Spironolactone now. What other drugs wou?

Here are some...: I am glad to see you have come thus far in MTF without SRS. To go further, it is important to rethink and reassess what may be your final goals to what stage of MTF; then decide what may be your further efforts which you would like to cope with so to fit your realistic personal/social readjustment. So, please bring all the related concerns to your treating doctor. ...Read more

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How often does the drug spironolactone cause breast enlargement in women?

How often does the drug spironolactone cause breast enlargement in women?

Not in women: Spironolactone (aldactone) is an antiandrogen, so it does have an effect to decrease testoterone, and there is an indirect estrogenic effect - which can cause breast enlargement (gynecomastia) and tenderness in men. Breast tenderness is occasionally reported in women, but this is unusual. ...Read more

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If spironolactone (for acne) is androgen blocker - how does this not have any interaction with androgenic progestin such as levonorgestrel/Mirena?

It could: The circulating levels of Progesterone secreted by Mirena (levonorgestrel) are very low making androgen side effects possible but uncommon. Spironolactone would decrease the androgenic effects if they were to be present although a doctor would not typically treat Mirena (levonorgestrel) side effects this way. If I were the physician treating someone with androgenic side effects of Mirena (levonorgestrel) I would just change birth control methods ...Read more

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Can I take aldactone (spironolactone) w/ another drug to lower my potassium levels? And both work to do their job? Aldactone (spironolactone) made me have high pot. But I want to take it

Can I take aldactone (spironolactone) w/ another drug to lower my potassium levels? And both work to do their job? Aldactone (spironolactone) made me have high pot. But I want to take it

It depends: It depends on why you're taking spironolactone (Aldactone). Suggest low potassium diet - especially avoid tomatoes, potatoes, bananas and orange juice (or V8 juice). Some people take an additional diuretic to lower potassium but these drugs have other side effects. ...Read more

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What does spironolactone do?

What does spironolactone do?

Receptor antagonist: Hi. Spironolactone blocks the aldosterone receptor and the testosterone receptor. Depending on the condition being treated, it is used for both purposes. ...Read more

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What is the use of spironolactone?

What is the use of spironolactone?

Many uses: Spironolactone is a diuretic and can be used to get rid of the body's extra fluid. It's also a aldosterone blocker and can be used to block the adverse effects of aldosterone on the heart and other tissues. It's also a testosterone blocker and can be used to decrease hair growth in patients with excessive hair. ...Read more

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Is taking 100mg of Spironolactone the right dosage?

Depends: It depends on why one is on spirolonolactone. The usual dose for treatment of hypertension is 12.5 - 50 mg daily dose. At times, up to 200 mg per day can be used in treating edema. ...Read more

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My skin is terrible. Will spironolactone help?

My skin is terrible. Will spironolactone help?

Terrible skin: I cannot answer that without more information. Dermatologists are the best doctors to help you with this. They are usually very busy and may have you wait a month or so before they can take you - be patient. ...Read more

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Does spironolactone become toxic if it's expired?

Does spironolactone become toxic if it's expired?

Uncertain: In general, it is recommended that medications not be used after expiration date. With that said, there is a big difference between being expired for 5 days versus 5 years. Your pharmacist should be able to provide more information. ...Read more

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What are long term effects of aldactone (spironolactone)?

Diuretic: Potassium sparing diuretic can lower blood pressure raise potassium not particularly strong. Also used high doses for cirrhosis of liver ...Read more

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While taking Aldactone (spironolactone) can you donate plasma?

While taking Aldactone (spironolactone) can you donate plasma?

Check with red cross: Thank you for thinking about blood donation, best to check with your local Red Cross center to find out current recommendations about aldactone, (spironolactone) I am available for second opinion if needed ...Read more

Dr. Sheila Smith
1 Doctor shared a insight

Drug Interaction (Definition)

When the combination of two agents cause an effect, intended or unintended, that would not have otherwise ...Read more


Dr. Milton Alvis Jr
236 Doctors shared insights

Aldactone (Definition)

Aldactone is a potassium-sparing agent which is a kind of water pill or diuretic (heart ...Read more