Doctor insights on:
Spindle Cell Tumor Benign
Invasive non keratinizing squamous cell carcinoma tongue showing nests of malignant squamous cells grade 3 prognosis?
Can be cured: If no nodes palpable and lesion localized, RT chemo can reduce size and position site for curative resection. Partial glossectomy after initial therapy. If larger and not responsive to chemo, Ive used hight dose MTX with citrovorum factor over 12 hrs. Most effective in presence of nodal disease Basic chemo is Platinum/Taxol + RT ...Read more
"tumor" literally translates as "mass", so even a fresh bruise could be called a "tumor". Doctors use the term "neoplasm" (tranlates literally as new growth) to describe tumors that are abnormal growths of cells. These may be benign or malignant; "malignant" = cancer. In everyday usage, we use "tumor" ...Read more
Genetic component?: There could be genetic component to a squamous cell cancer, although the exact implications on treatment aren't known. Obviously if there is a strong family history of cancers, or if it strikes someone who is young and/or a non smoker/drinker i would suspect a strong genetic contribution. Without more details, it is hard to say with any certainty. ...Read moreSee 1 more doctor answer
Are carcinoid tumors carcinoma? Is malignant metastatic stomach carcinoma that's hereditary a carcinoid cancer? carcinoid Neuroendocrine tumors?
If both benign and malignant tumours are formed by abnormal cell division, what makes malignant tumours cancerous and benign tumours non-cancerous?
Power to invade: Tumors are in fact caused by the accumulation of a series of genetic mutations. If something is going to be cancer, the mutations destabilize the genome and eventually mutations give the ability of the cells to invade and spread as they do early after conception. The idea that tumors are "cells dividing too rapidly" is fundamentally wrong and confusing -- it's the loss of controls. ...Read more
The gonads produce: Sperm in men (&testosterone) and eggs/ova in women (& estrogens), and these are also the sites of germ cell tumors. Outside the gonads, the mediastinum and brain (pineal) are the most common extragonadal sites. These are known to produce markers (hcg, alphafeto-protein) and responsve and curable with chemotherapy. Hope this helps. ...Read moreSee 1 more doctor answer
Depends: A thymoma is a malignant tumor of the thymus, and the seriousness depends on details in the pathology report. An ectopic thymus and a hamartoma are both benign, but if the report says "thymoma" then it is probably malignant although not necessarily very serious if completely removed. Discuss with your surgeon! ...Read moreSee 1 more doctor answer
No.: By definition, a benign tumor does not metastasize (spread to other sites by invading the blood stream or lymphatic system). Extremely rare cases of 'parasitic' or implanted benign tumors (eg leiomyomas of the uterus) are recognized to occur in sites outside their normal origin, but this is thought to be a result of some form of tissue transplantation, and not true tumor ''metastasis' ...Read more
Not really: Not necessarily. It could appear suddenly and grow rapidly. But then it will reach a certain size then it will stop growing, and then regress weeks to months later. As long as it is contained, localized in the skin- surgical resection will take care of that . However if it has metastasized ( which is not common ) -then it will give you problem. ...Read more
Yes: All tumors arise from normal pre existing cells that have undergone some form of transformation. Several oncogenes are turned on to present the benign as well as malignant lesion with immortality. In the case of the malignant tumor additional changes allow for matrix metalloproteinase to be produced to dissolve walls of blood vessels for metastasis and convert e-cadherin to small e cad. ...Read more
Small cell was: Distinguised because there is almost never a role for surgery, and always a role for chemotherapy. Non-small cell prior to 1980 never had chemotherapy. Both are caused by smoking sclc 100%; /nsclc 90-95%. Nsclc just in lung usually treated with surgery. Any + node gets chemo. If mediastinal nodes are positive, standard is chemo/xrt. Get more than 1 opinion before starting treatment if yo have ? ...Read more
Interesting tumor: Overally, neuroendocrine tumors are often capable of over-producing hormones that your body naturally makes. Islet cells are cells that are naturally present in the pancreas and produce a number of hormones, most notably insulin. Insulin helps you break down and digest sugars. Patients with an islet cell tumor can produce too much Insulin resulting in weight & gain and low blood sugars. ...Read moreSee 1 more doctor answer
Not necessary: Hurtel cell neoplasm can be adenoma (not cancer) or carcinoma (cancer). There is not much difference between the two with regards to age, sex, or history of head and neck radiation. However, hurtle cell carcinoma (cancer) tends to be larger in size (4.0 +/- 0.4 cm) compared with hurtle cell adenoma (2.4 +/- 0.2 cm). ...Read more
Mesothelioma biopsy says 'portions of fibrous tissue infiltrated by malignant cells forming nests. tumor cells +'ve for CK7 and calretinin. prognosis?
Marker not prognosis: CK7 and calretinin are used to verify that the tumor is mesothelial in origin (versus adenocarcinoma of the lung). It does not provide information about prognosis. Factors associated with pleural mesothelioma prognosis include: functional status, blood counts, histology (epithelial best vs fibrosarcomatous poorest), and tumor size (degree of involvement of pleural cavity). Several new trials. ...Read more
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