Doctor insights on:
Spindle Cell Cancer Treatment
See below: Treatment of small cell lung cancer depends on the stage. If it is limited stage the treatments involve chemotherapy along with radiation and if it is extensive stage then chemotherapy is the main stay of treatment (though in some situations palliative radiation can be considered). ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
Has anyone had any experience in a cancer treatment called torisel (temsirolimus) for renal cell carcinoma, and how were the results?
It is a drug that targets a defect in kidney cancer cells. It is give iv. The goal of this drug is to slow down the growth of cancer cells and to shink the tumor and extend life and function.
I have used it in some patients with good results and reasonable side effects. It is not a cure. ...Read more
Limited to chest-LD: Or with disease outside-ed? Cornerstone for all treatment is chemotherapy with a platin and Etoposide chemotherapy, and in LD chest xrt, as early as possible. In LD & ed, all responders get brain radiotherapy to prevent brain metastasis. Ed pts sometimes get chest rt then too. ...Read more
Immune replacement: Very generally speaking, currently the stem cells given for cancer are stems cells meant to replace the immune system. So you are able to get high dose treatment for the cancer, which is highly toxic to your immune system. The stem cells transplant is able to replace your immune system. ...Read more
Depends on stage:
If you have kidney cancer that is still within the kidney, we would usually recommend surgery.
If you have kidney cancer that has spread outside the kidney, sometimes surgery would still be helpful, but most people will require systemic treatments including targeted therapy or immunotherapy. These are IV or oral medications that target specific pathways to treat kidney cancer that has spread. ...Read more
Small cell lung ca: In limited disease, tx would be combination chemo and radiation. In a very limited case, surgery can be done if size is very small, absolutely no spreading to any area/adjacent lymp glands etc. Prophylactic radiation to brain is recommended. In extensive disease, chemo will be the tx. Palliative radiation as needed. For chemo responder, prophylactic radiation to brain can increase survival. D/w md. ...Read more
A person with cancer is given high dose chemotherapy that kills cancer but also kills normal bone marrow. Stem cell transplants reconstitute bone marrow to permit survival. See this site for more info.
http://www. Cancer. Org/treatment/treatmentsandsideeffects/treatmenttypes/bonemarrowandperipheralbloodstemcelltransplant/stem-cell-transplant-types-of-transplant. ...Read more
Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies.
Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide
proteasome inhibitors - eg, bortezomib, carfilzomib, etc
other: hsp90 inhibitors, hdaci, b-raf, etc.
Over the last few years multiple new drugs have been approved for myeloma. ...Read more
Ask doctor: If they did biopsy they can schedule treatment once the diagnosis is confirmed. Size, location will dictate treatment options such as excision with primary closure, skin graft or flap. If it is small curettage may be option. If it is large greater than 2 cms. On the face or scalp, or in certain difficult areas such as the eyelids, near the ear, side of the nose mohs may be best option. ...Read more
Why to do chemotherapy if cancer cells can still be left behind for reccrrence after the treatment? Doesn;t chemo kill all the cells?
Cure is our goal...: Some people can be completely cured of their cancer using chemotherapy, while others eventually relapse and their cancer comes back. Our goal with chemotherapy is to rid the body of all cancer cells, but sometimes this doesn't work. We are not that good at predicting upfront who will be cured and who will relapse, so that is why we try and see what happens. This is an area of intense research. ...Read more
Does the presence of spindle cells in a pap smear always indicate cancer or can they be present with moderate or severe dyskariosis? Ie cin3?
Not always cancer: Spindle cells (sc) have bilateral tapering poles (like a football); their presence on pap smear indicates issues ranging from benign reactive or reparative changes, artifactual/normal squamous cell shape, to rare malignancies (carcinosarcoma, metastatic desmoplastic melanoma). Sc morphology is seen in connective tissue. Pap grade (high or low intraepithelial lesions, cin 1-3) is more tellig. N. ...Read more
I had an abnormal smear 2yrs ago and had laser treatment to remove pre cancer cells is there a chance it may happen again?
Possibly: There's an unofficial rule some of us follow: if you had it once, you are at increased risk for having it again. Doesn't mean you will, but that you can. Some things that need to be considered. For instance if you were diagnosed with high risk hpv which greatly increases your risk for cervical cancer. This is why we emphasize that boys and girls up until the age of 26 be vaccinated against hpv. ...Read more
Hi, What chances of cancer by doing Autologous Adipose derived stem cell treatment. Pls help. Thanks?
There isn't much but this depends on the context of why there is the transplant. It is used either in cancer
http://www. Wjgnet. Com/1948-9366/full/v8/i2/161.htm
or reconstructive surgery. In someone without cancer, they don't even do studies to evaluate risk since the risk is assumed zero. ...Read more
I've got a question. If they find cancer cells in a male testicles, does that mean they have cancer and do they give treatment for cancer cells?
Testis cancer causes: A lump in a testicle. We check markers (alpha feto protein, hcg). We remove the testis through the inguinal canal/incision. We do not violate the scrotum. We assess for nodes by ct scans of the para-aortic and kidney hila. We do not sample "cells" but look at the tumor in place after it is removed. Different cell types get different treatment. These are cancers. ...Read more
Pap Smear result: A single group of spindle cells admixed with neutrophils is seen representing atypical spindle cell proliferation. Is it cancer?
Several points. First, you need more than atypical to say it is cancer. They have to look quite abnormal and/or be growing abnormally. HOWEVER, there are reports of groups of atypical spindle cells popping up everywhere due to cancer (lymphoma). That would be cancer. Or growing really fast (cancer).
At a minimum. Watching it Really closely. ...Read more
History of uterine cancer- after initial treatment, during check up, doctors said there are "cells" and need further check up. Is it recurrent cancer?
It would be worrisome to have abnormal cells in a patient with a history of uterine cancer, so the appropriate thing to do is follow your doctor's recommendations for further evaluation.
However, just because there are cells that require further evaluation does not mean that the cancer has returned. ...Read more
Curative tx for nsclc is surgical.
Stage 1-surgical resection 70%5yr survival
stage 2- surgical resection 30-35% 5 yr survival
stage3 chemo/rtx/surgical combo approx.1- 3-% 5 yr surv.
Stage 4 chemo/radiotx 0-.5%5yr surv. ...Read more
12 months or less: Small cell lung cancer is an aggressive disease. It is highly sensitive to chemotherapy and/or radiation therapy but it tends to recur. If the disease is limited, cure can be achieved with proper treatment. If the disease is extensive, cure is not feasable but treament can improve or delay symptoms and can help patients live longer. Without treatment, survival is 6 to 12 months. ...Read more
What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?
1) diagnosis - myeloma vs.?
2a) stage - iss (not that relevant for individual)
2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc.
3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. ...Read more
If I have stage one pre cancer cells on my cervix how fast can it turn into cancer and what are best treatment options?
Cervical cancer: Precursor lesions to cervical cancer (LSIL, HSIL) usually appear 10 or more years before an invasive cancer, but are not always detected immediately upon appearance. Colposcopy and bx are used to exclude the presence of something worse than what was seen on Pap test. If detected visually, then local excision using electrocautery, is usually effective, but f/u needed until HPV neg. Cryo occ. Poss ...Read more
Wondering why should I take treatment if I was diagonsed with stage3non small cell squamous t2 lung cancer?
Better results: Lung cancer survival results decrease with increasing stages. Stage 3 is best treated with combination therapy, with chemotherapy and radiation either preceding surgery or following it. The combination of therapies, as well as the timing, are all the subject of multiple clinical trials. ...Read more
After going through treatment for primary brain tumor is there a way to tell if there are any live cancer cells?
No: Imaging with MRI will give the best evaluation to see if there is any remaining tumor. Often the changes from surgery and radiation might leave abnormal scan. Evaluating the symptoms and any growth in repeat scans determines any activity. Using dedicated brain pet or spect scans may give a better idea of live or active cells but this is not done often since the treatment was just accomplished. ...Read more
What is the followup treatment for kidney cancer t1a, clear cell type, grade 3? Will ultrasounds work or do you need catscans?
Follow up after surg:
The nccn guidelines suggest follow-up with your doctor, blood work every 3 then 6 months. A ct is suggested at 2-6 months and as needed.
You can look at recommended follow up on nccn. Org. Also t1a should have a a good outcome.
I would ask my doctor for the whole plan of follow up. There are often reasons why they might suggest something different than the guidelines. ...Read more
How do I know the chemo treatment for breast cancer has affected my good normal cells what damage does it cause to my body?
Your oncologist can: Your treatiig oncologist can address this issue easily. Chemotherapy has but temporary effects on your blood counts. These go away within 3-4 weeks after stopping chemotherapy. There is little concern about long term aeffects on your body as the body can take care of repaiing itself quite quickly. So I would advise you not to worry about it...Yet ask such questions to the oncologist who ahs treated. ...Read more
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- Malignant spindle cell sarcoma
- Atypical spindle cell
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