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Doctor insights on: Spep Alpha1 Ife

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SPEP test: High Alapha1. 27 (.10-.20) High Alpha1% 3.6% (1.4-2.7%) High Gama 1.23 (.6-.1.2) Low Beta 5.9% (6-9%) and IFE tested positive. Cancer?

SPEP test: High Alapha1. 27 (.10-.20) High Alpha1% 3.6% (1.4-2.7%) High Gama 1.23 (.6-.1.2) Low Beta 5.9% (6-9%) and IFE tested positive. Cancer?

Need more info: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, none of the information you provided suggests cancer. Ife was positive for what?
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more

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In an spep why is reg albumin ok and the % low? Alpha 1 % high and just beta high? Inflammatory? The% confuses me.

In an spep why is reg albumin ok and the % low? Alpha 1 % high and just beta high? Inflammatory? The% confuses me.

Many benign causes: Almost any virus or other exposure that provokes your immune system can produce a "defensive " or protective response. Albumin is a useful parameter that indicates your nutritonal status is not the issue. Beta is indicative that your system is protecting itself. ...Read more

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Had normal spep test but heard about alpha1-antitrypsin deficiency while web surfing, now im concerned. My alpha-1-globulin, was normal 0.25 (0.17 - 0.50 g/d). No symptoms - should I take a1ad test?

Had normal spep test but heard about alpha1-antitrypsin deficiency while web surfing, now im concerned. My alpha-1-globulin, was normal 0.25 (0.17 - 0.50 g/d). No symptoms - should I take a1ad test?

Symptoms...: Alpha 1 antitrypsin deficiency typically presents as chronic obstructive pulmonary disease, or copd, at a younger age. If members of your family have copd, and it was diagnosed younger than usual (like 20s-30s, for example), then it would be reasonable to get tested. But, if neither you nor family members have been diagnosed with copd, then it is unlikely you have Alpha 1 antitrypsin deficiency. ...Read more

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What does a high alpha 1 protein electrophoresis mean?

What does a high alpha 1 protein electrophoresis mean?

Inflammation: Serum protein electrophoresis is a test that examines specific proteins in the blood, serum Albumin and alpha-1, alpha-2, beta, and gamma globulins. In the alpha-1 zone, alpha-1 antitrypsin (aat) is the major protein, which is involved in neutralizing enzymes secreted by inflammatory cells. Aat is increased in acute inflammation. ...Read more

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I had normal serum protein electrophoresis. Alpha-1-globulin is 0.25 (0.17 - 0.50 g/dl). Low end of normal? Do I need to test for alpha1-antitrypsin?

I had normal serum protein electrophoresis. Alpha-1-globulin is 0.25 (0.17 - 0.50 g/dl). Low end of normal? Do I need to test for alpha1-antitrypsin?

No: Don't bother. What would you do with a result? I'm going to assume that you are a non-smoker and that at age 31 your exercise tolerance is like your peers. You're probably not a candidate for pricey, inconvenient replacement. ...Read more

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Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?

Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more

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Testing for AL amyloid. SPEP shows no M-spike but mildly elevated total protein & A/G ratio (2.7) due to high albumin. Globulins well within normal range. Worrisome? Serum/urine IFE &marrow biopsy ok, but elevated free K/L ratio due to low lambda.

OK: This is a thorough work up, the K/L ratio would not concern me in this instance unless either of the components were high, In that case I would check a bone marrow, which you have already confirmed as normal ...Read more

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What is an spep test? What is it used for?

Bloodwork: Serum protein electrophoresis is most often performed as a screen for plasma cell myeloma. ...Read more

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I had normal spep test what are he chances my free light chains test will be abnormal? Is this a similar test?

SPEP FLC Lab tests: The serum protein electrophoresis (SPEP) with immunofixation (IFE) and the free light chain (FLC) kappa to lambda ratio tests are related and complementary laboratory tests for plasma cell dyscrasias such as multiple myeloma. Screening is often done with both SPEP + FLC and both can be used to follow myeloma treatment. If SPEP is negative, FLC k/l ratio can still be abnormal. ...Read more

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SPEP results said monoclonal protein can't be ruled out. What does this mean?

SPEP results said monoclonal protein can't be ruled out. What does this mean?

May need repeat chec: SPEP is a test looking for an abnormal protein in the blood. When present, it produces a separate peak than the one produced by the normal proteins. The report you have sent is ambiguous!
So a second opinion or repeat test may help. Another (better test) is called Immunofixation test. You need to go see a Myeloma (a type of Bone marrow Cancer) specialist to help you further. ...Read more

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I got a Total protein test and it was 8.9 normal range is 6.3-8.2. I have raynolds disease and my Dr ordered an SPEP test what does it mean?

I got a Total protein test and it was 8.9 normal range is 6.3-8.2. I have raynolds disease and my Dr ordered an SPEP test what does it mean?

SPEP: SPEP stands for serum protein electrophoresis. It is commonly used to separate out and identify abnormal protein in the blood called M-protein. Increased level of M-protein can be caused by infection, inflammation or cancer such as multiple myeloma. Myeloma is a cancer of the plasma cells in bone marrow, which can produce excessive monoclonal M-protein detected by SPEP. ...Read more

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Still seeing doctors for health issues - awaiting FLC result. SPEP normal but flagged very low beta band - not malnourished, what could this mean?

Still seeing doctors for health issues - awaiting FLC result. SPEP normal but flagged very low beta band - not malnourished, what could this mean?

What is flc: Hard to answer the low beta may be related but we need to know you underlying immunoglobulin levels. This may not related to your health issues ...Read more

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How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and I had that?

Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy. The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe. Discuss with your rheumatologist further. ...Read more

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ITP for14yrs. Last 3 yrs several spep and they alternate between polyclonal and monoclonal IgM 2.09 to 3.05 and nothing. Sflc negative, bjp negative?

Mgus: You probably have a very low level monoclonal gammopathy of undetermined significance. These abnormal antibodies are common in people with autoimmune disease and with the other studies being normal it will have no clinical significance most likely. ...Read more

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"spep - all levels normal but at the bottom, test says 'faint band in gamma region suspicious for monoclonal immunoglobulin'. My pcp wasn't worried, didn't want to test further. Should I be concerned?

"spep - all levels normal but at the bottom, test says 'faint band in gamma region suspicious for monoclonal immunoglobulin'. My pcp wasn't worried, didn't want to test further. Should I be concerned?

At your age, no!: A monoclonal gammopathy is rare at your age. Number two, they takes decades usually to express themselves. Number three, not all become multiple myeloma, and number four, multiple myeloma is no quite treatable. I have many patients followed for years in late seventies, who still rquire no treatment. Simply repeat the test yearly. I would quantify the specific gammaglobulins as well, yearly. ...Read more

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If my sister's doctor ordered a spep test for her, does this mean only very serious diseases are suspected? Like myeloma?

If my sister's doctor ordered a spep test for her, does this mean only very serious diseases are suspected? Like myeloma?

SPEP: The serum protein electrophoresis (spep) is laboratory test to evaluate for a monoclonal (m) protein or "spike". This is different than an inflammatory polyclonal elevation of proteins (eg, hiv, hepatitis, etc). Spep "+" may be cancers such as myeloma (mm), cll, lymphoma. It may also be + increasingly with age as in mgus - monoclonal gammopathy of undetermined significance. Risk 1%/yr of mm. ...Read more

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Doctor told me I had no sinitis but a lot of proteins in my blood she said not to worry, the test she drew was spep, why do I have lots of proteins?

Doctor told me I had no sinitis but a lot of proteins in my blood she said not to worry, the test she drew was spep, why do I have lots of proteins?

It needs further tes: Excess of proteins in the blood can occur due to a number of medical conditions, some of which are infections or are of inflammatory in nature. Therefore, you should seek full evaluation to find the cause and confirm if this probelm is real or a lab error.
An internist or hematologist can easily investigate this problem. ...Read more

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Read that Bence Jones Protein can sometimes appear in 24 hr urine and be missed/normal in serum Free Light Chain Assay? Normal SPEP but no UPEP done..

Read that Bence Jones Protein can sometimes appear in 24 hr urine and be missed/normal in serum Free Light Chain Assay? Normal SPEP but no UPEP done..

No consensus: The serum free light chain assay is newer and is supposed to detect free light chains in serum even before they are detectable in urine. The old protocol was with plasma electrophoresis and urine protein immunofixation. It all depends now on the hematologist's confidence level in the new test. ...Read more

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I have history of elevated blood protein (8.3-8.7 since 09). Recently did spep with elevated gamma globulin. Why would pcp refer me to hematologist?

I have history of elevated blood protein (8.3-8.7 since 09). Recently did spep with elevated gamma globulin. Why would pcp refer me to hematologist?

Elevated gamma glob: Do you have an m-spike detected on your serum protein electrophoresis? Do you have an imimmunofixation electrophoresis? If you do have m-spike detected- your pcp refers you to see hematologist to make sure you don't have plasma cell disorder etc. Elevated gamma glob alone without m-spike or abnormal ife- could be caused by inflammation, infection etc. Ask this question to your pcp. ...Read more

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Worried. Gastro says only test left is mra. Cant regain weight. Still have pain. Went to general oncologist. Spep test fine. No cancers she feels. Ideas?

Worried. Gastro says only test left is mra. Cant regain weight. Still have pain. Went to general oncologist. Spep test fine. No cancers she feels. Ideas?

Abdominal pain: If you are dissatisfied with the opinions you have received the best advice would be to obtain a second opinion from somebody with access to your medical records, history and the ability to examine you. This is not something which could possibly be resolved over the internet. Good luck and best wishes. ...Read more

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I am wondering with normal SPEP, Bone marrow Biopsy, PET Scan All normal, high B2M is there chances for Myeloma or Waldenström's macroglobulinemia?

I am wondering with normal SPEP, Bone marrow Biopsy, PET Scan All normal, high B2M is there chances for Myeloma or Waldenström's macroglobulinemia?

Yes: There is no test that will completely exclude nay diagnosis. In additon, b2m is a marker for all lymphoid disease (CLL, NHL, Hodgkin etc.) In any event, with the above negatvie studies the chances of you having lymphoma/myeloma missed is excedingly small ...Read more

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Can bronchitis, sinus infection and fever cause ESR to go up? Mines was 110, now I feel 100% (4 weeks later) it's back to normal. They since tested me for ANA, SPEP and other countless test. Normal.

Can bronchitis, sinus infection and fever cause ESR to go up? Mines was 110, now I feel 100% (4 weeks later) it's back to normal. They since tested me for ANA, SPEP and other countless test. Normal.

Not surprising: The ESR can be a measure of inflammation and increase when sinuses and bronchi are infected or inflammed. The ESR should return to normal when treatment is complete and effective ...Read more

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What would cause extremely low hypocellular bone marrow - 15% normal, 65% really hypocellular and 15% mild-moderately low; I am 40 yr old male with 20lbs weight loss, spinal pain, SOB, headaches, low ferritin and really high B12, folate; normal spep.

What would cause extremely low hypocellular bone marrow - 15% normal, 65% really hypocellular and 15% mild-moderately low; I am 40 yr old male with 20lbs weight loss, spinal pain, SOB, headaches, low ferritin and really high B12, folate; normal spep.

One marrow failure: Can be due to several causes as radiation, certain drugs, tumours, and others. You need to be under the care of a hematologist, whom you may have already seen, kindly keep the follow up, wish you all the best, at this limited platform we can't really offer much in your case, good luck ...Read more

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Have APS, does it Cause High B2M? Normal CT/PET and Bone marrow Biopsy. High LDH, Spleenomegaly, Normal SPEP, Night sweat, tired, Low platelete& RBC

Have APS, does it Cause High B2M? Normal CT/PET and Bone marrow Biopsy. High LDH, Spleenomegaly, Normal SPEP, Night sweat, tired, Low platelete& RBC

Not necessarily: The B2M protein is "non-specific: and not necessarily associated with APS I am going to refer your question to one of our HEMATOLOGY/ONCOLOGY experts. This referral should not frighten you! It is simply to help you find out more about your clinical situation.
Hope this helps
Dr Z ...Read more

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What could cause high protein electrophoresis urine. 21 G/L?

What could cause high protein electrophoresis urine. 21 G/L?

Unclear question: Do you have high protein in the urine? If the protein concentration in urine is 0.21 gm/dL, that warrants an investigation of the kidney function. If you are diabetic, it is all the more important that you consult your doctor, even though protein in urine by itself warrants seeing your doctor. ...Read more

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What does a high alpha 2 protein electrophoresis indicate?

Nothing Particular: It is one of those changes which has no clear cut medical implications. You can ignore it and you would not have to think about it or anything serious that I can medically relate it to. Good like ...Read more

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Does protein electrophoresis serum help to rule out lymphoma?

Does protein electrophoresis serum help to rule out lymphoma?

No: Basically worthless. You're way too young for myeloma. Matt, you've been concerned about lymphoma for months. You're a smart guy at your mental and physical peak. There must be some bold, decisive actions you can take, with good guidance, to make your life better and more fulfilled, so that these concerns won't torment you. You deserve better. Best wishes. ...Read more

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Serum protein electrophoresis - hight beta fraction, what does this mean?

Serum protein electrophoresis - hight beta fraction, what does this mean?

Unimportant: Tell us your values of all proteins. The only two that matter are Albumin and Gamma Globulin. A M spike (monoclonal peak) can be abnormal...so look for this, otherwise you are ok and can ignore the beta fraction. ...Read more

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Doesn't immunofixation test for the same things as protein electrophoresis and even more than protein electrophoresis?

It is not same test: Serum protein electrophoresis (spe) is a screening test for myeloma and other paraproteinemias it simple shows the abnormal (m) protein peak.
Immunofixation is the next best test which provides a lot more additional information like the type of immunoglobulin which is causing the m spike and it will also tell us more useful info about further quantitation of the m peak and subtyping of your disease. ...Read more

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Is a IgG quantitative test same as the serum protein electrophoresis test?

Blood tests: They are two different separate blood tests, spep serum protein electrophoresis test is a screening test for plasma cell disorders like mgus, smoldering or full blown myeloma and quantitative igg is a blood test to quantify the amount of igg in blood. Usually more than 3 grams is significant in blood. ...Read more

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Will the serum protein electrophoresis test tell me anything that the immunofixation test would not tell me?

Yes.: The ife is very sensitive at finding an abnormal antibody (monoclonal antibody) in blood, but it does not measure the quantity. The spep is less sensitive at finding the monocloprotein protein, but it is a quantitative test, so it answers "how much" monoclonal protein is present. The spep is used to monitor therapy for that reason. ...Read more

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Doc wants to do protein electrophoresis test. Globulin always low and a/g always high. Could globulin just be low due to my igg3 deficiency, though?

Globulin: Globulin production affects immunoglobulin
production, hence your low igg3 is a result of your low globulin level and this needs to be investigated. Your doctor is right. ...Read more

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M58, could RA factor test rule out rhemetoid artheratis and protein electrophoresis, serum calcium, fbc, ESR rule out multiple myleoma up to some extnt?

M58, could RA factor test rule out rhemetoid artheratis and protein electrophoresis, serum calcium, fbc, ESR rule out multiple myleoma up to some extnt?

See details: The ccp antibody is a more specific test for ra. 20-25% of people with RA have a negative rheumatoid factor. The protein electrophoresis is an important diagnostic test for myeloma but the diagnosis is really made through a bone marrow exam. A normal spep, however, rules out myeloma. ...Read more

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What is the difference in the utility of these 2 tests: IgG subclass (1-4) serum blood test.......And......Serum protein electrophoresis?

Proteins: Igg is an immunoglobulin produced in the body to defends us from infection and inflammation, it is subdivided in 4 subclasses which all have different fucntions, the serum protein electrophoresis is going to measure the distribution of proteins in the blood to determine if there is an abnormal protein production. ...Read more