Doctor insights on:
Spep Alpha1 Ife
SPEP test: High Alapha1. 27 (.10-.20) High Alpha1% 3.6% (1.4-2.7%) High Gama 1.23 (.6-.1.2) Low Beta 5.9% (6-9%) and IFE tested positive. Cancer?
Need more info:
All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, none of the information you provided suggests cancer. Ife was positive for what?
For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form.
Practice safe sex.
Get HPV vaccine. ...Read more
In an spep why is reg albumin ok and the % low? Alpha 1 % high and just beta high? Inflammatory? The% confuses me.
Had normal spep test but heard about alpha1-antitrypsin deficiency while web surfing, now im concerned. My alpha-1-globulin, was normal 0.25 (0.17 - 0.50 g/d). No symptoms - should I take a1ad test?
Symptoms...: Alpha 1 antitrypsin deficiency typically presents as chronic obstructive pulmonary disease, or copd, at a younger age. If members of your family have copd, and it was diagnosed younger than usual (like 20s-30s, for example), then it would be reasonable to get tested. But, if neither you nor family members have been diagnosed with copd, then it is unlikely you have Alpha 1 antitrypsin deficiency. ...Read more
Inflammation: Serum protein electrophoresis is a test that examines specific proteins in the blood, serum Albumin and alpha-1, alpha-2, beta, and gamma globulins. In the alpha-1 zone, alpha-1 antitrypsin (aat) is the major protein, which is involved in neutralizing enzymes secreted by inflammatory cells. Aat is increased in acute inflammation. ...Read more
I had normal serum protein electrophoresis. Alpha-1-globulin is 0.25 (0.17 - 0.50 g/dl). Low end of normal? Do I need to test for alpha1-antitrypsin?
No: Don't bother. What would you do with a result? I'm going to assume that you are a non-smoker and that at age 31 your exercise tolerance is like your peers. You're probably not a candidate for pricey, inconvenient replacement. ...Read more
I had normal serum protein electrophoresis. Alpha-1-globulin is 0.25 (0.17 - 0.50 g/dl). Low end of normal? Test for alpha1-antitrypsin? Dr not concerned. I have mild asthma (no wheezing, coughing, etc
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
Clinical context: The use of light chains is limited in diseases other than monoclonal gammopathies, such as myeloma or amyloidosis. If this is the context that yours got checked the results do not suggest such a condition. With no gammopathy suggested by results the question regarding clonality has no grounds. As any other test, trending the results would help in integrating it in a meaningful clinical context. ...Read more
Testing for AL amyloid. SPEP shows no M-spike but mildly elevated total protein & A/G ratio (2.7) due to high albumin. Globulins well within normal range. Worrisome? Serum/urine IFE &marrow biopsy ok, but elevated free K/L ratio due to low lambda.
I had normal spep test what are he chances my free light chains test will be abnormal? Is this a similar test?
SPEP FLC Lab tests: The serum protein electrophoresis (SPEP) with immunofixation (IFE) and the free light chain (FLC) kappa to lambda ratio tests are related and complementary laboratory tests for plasma cell dyscrasias such as multiple myeloma. Screening is often done with both SPEP + FLC and both can be used to follow myeloma treatment. If SPEP is negative, FLC k/l ratio can still be abnormal. ...Read more
May need repeat chec:
SPEP is a test looking for an abnormal protein in the blood. When present, it produces a separate peak than the one produced by the normal proteins. The report you have sent is ambiguous!
So a second opinion or repeat test may help. Another (better test) is called Immunofixation test. You need to go see a Myeloma (a type of Bone marrow Cancer) specialist to help you further. ...Read more
I got a Total protein test and it was 8.9 normal range is 6.3-8.2. I have raynolds disease and my Dr ordered an SPEP test what does it mean?
SPEP: SPEP stands for serum protein electrophoresis. It is commonly used to separate out and identify abnormal protein in the blood called M-protein. Increased level of M-protein can be caused by infection, inflammation or cancer such as multiple myeloma. Myeloma is a cancer of the plasma cells in bone marrow, which can produce excessive monoclonal M-protein detected by SPEP. ...Read more
Still seeing doctors for health issues - awaiting FLC result. SPEP normal but flagged very low beta band - not malnourished, what could this mean?
What is flc: Hard to answer the low beta may be related but we need to know you underlying immunoglobulin levels. This may not related to your health issues ...Read more
How does having polyclonal gammopathy correlate with lupus- I have lupus and polyclonal gammopathy does having this mean you have a more severe form of lupus, they did an spep be4 lupus and I had that?
Polyclonal gamma pat: Polyclonal gammoparhy is seen frequently in chronic inflammation/ autoimmune disorder etc. Lupus is certainly one of the condition that causes/ associated with polyclonal gammopathy. The presence of polyclonal gammopathy does not tell you whether the lupus will be more severe or less severe. Discuss with your rheumatologist further. ...Read more
ITP for14yrs. Last 3 yrs several spep and they alternate between polyclonal and monoclonal IgM 2.09 to 3.05 and nothing. Sflc negative, bjp negative?
Over 18 months ill defined igmkappa, then no m protein on spep and light chain, then two times IgM polyclonal then illdefined igmkappa, serum igm2.9g/l?
Watchful waiting: The test should be repeated in 6 month. ...Read more
"spep - all levels normal but at the bottom, test says 'faint band in gamma region suspicious for monoclonal immunoglobulin'. My pcp wasn't worried, didn't want to test further. Should I be concerned?
At your age, no!: A monoclonal gammopathy is rare at your age. Number two, they takes decades usually to express themselves. Number three, not all become multiple myeloma, and number four, multiple myeloma is no quite treatable. I have many patients followed for years in late seventies, who still rquire no treatment. Simply repeat the test yearly. I would quantify the specific gammaglobulins as well, yearly. ...Read more
If my sister's doctor ordered a spep test for her, does this mean only very serious diseases are suspected? Like myeloma?
SPEP: The serum protein electrophoresis (spep) is laboratory test to evaluate for a monoclonal (m) protein or "spike". This is different than an inflammatory polyclonal elevation of proteins (eg, hiv, hepatitis, etc). Spep "+" may be cancers such as myeloma (mm), cll, lymphoma. It may also be + increasingly with age as in mgus - monoclonal gammopathy of undetermined significance. Risk 1%/yr of mm. ...Read more
Doctor told me I had no sinitis but a lot of proteins in my blood she said not to worry, the test she drew was spep, why do I have lots of proteins?
It needs further tes:
Excess of proteins in the blood can occur due to a number of medical conditions, some of which are infections or are of inflammatory in nature. Therefore, you should seek full evaluation to find the cause and confirm if this probelm is real or a lab error.
An internist or hematologist can easily investigate this problem. ...Read more
Apart from myeloma, can MGUS be found in urine only (UPEP) with a normal SPEP? Or does it always show in blood?
No to 1, yes to 2: It always will be present in serum if it is truly present. ...Read more
Read that Bence Jones Protein can sometimes appear in 24 hr urine and be missed/normal in serum Free Light Chain Assay? Normal SPEP but no UPEP done..
No consensus: The serum free light chain assay is newer and is supposed to detect free light chains in serum even before they are detectable in urine. The old protocol was with plasma electrophoresis and urine protein immunofixation. It all depends now on the hematologist's confidence level in the new test. ...Read more
I have history of elevated blood protein (8.3-8.7 since 09). Recently did spep with elevated gamma globulin. Why would pcp refer me to hematologist?
Elevated gamma glob: Do you have an m-spike detected on your serum protein electrophoresis? Do you have an imimmunofixation electrophoresis? If you do have m-spike detected- your pcp refers you to see hematologist to make sure you don't have plasma cell disorder etc. Elevated gamma glob alone without m-spike or abnormal ife- could be caused by inflammation, infection etc. Ask this question to your pcp. ...Read more
Worried. Gastro says only test left is mra. Cant regain weight. Still have pain. Went to general oncologist. Spep test fine. No cancers she feels. Ideas?
Abdominal pain: If you are dissatisfied with the opinions you have received the best advice would be to obtain a second opinion from somebody with access to your medical records, history and the ability to examine you. This is not something which could possibly be resolved over the internet. Good luck and best wishes. ...Read more
I am wondering with normal SPEP, Bone marrow Biopsy, PET Scan All normal, high B2M is there chances for Myeloma or Waldenström's macroglobulinemia?
Can bronchitis, sinus infection & fever cause ESR to go up? Mines was 110, now I feel 100% (4 weeks later) it's back to normal. Tested ANA, SPEP & other test all Normal. Btw this was 4 years ago.
Sed rate: Is a non-specific indicator of inflmmation and/or infection. It seems likely that it was the response to your previous infection. ...Read more
Can bronchitis, sinus infection and fever cause ESR to go up? Mines was 110, now I feel 100% (4 weeks later) it's back to normal. They since tested me for ANA, SPEP and other countless test. Normal.
What would cause extremely low hypocellular bone marrow - 15% normal, 65% really hypocellular and 15% mild-moderately low; I am 40 yr old male with 20lbs weight loss, spinal pain, SOB, headaches, low ferritin and really high B12, folate; normal spep.
One marrow failure: Can be due to several causes as radiation, certain drugs, tumours, and others. You need to be under the care of a hematologist, whom you may have already seen, kindly keep the follow up, wish you all the best, at this limited platform we can't really offer much in your case, good luck ...Read more
Liver ALT test almost always on high end of normal reference range. Ct scan, ultrasound, hep test, ana, spep negative. Gastro said not to worry. Sometimes ALT is elevated over a few pts. More test?
Take it easy: Follow your doctor's advice. You may not need further testing. Just keep checking liver enzymes every six months to ensure all is well. ...Read more
Have APS, does it Cause High B2M? Normal CT/PET and Bone marrow Biopsy. High LDH, Spleenomegaly, Normal SPEP, Night sweat, tired, Low platelete& RBC
The B2M protein is "non-specific: and not necessarily associated with APS I am going to refer your question to one of our HEMATOLOGY/ONCOLOGY experts. This referral should not frighten you! It is simply to help you find out more about your clinical situation.
Hope this helps
Dr Z ...Read more
Unclear question: Do you have high protein in the urine? If the protein concentration in urine is 0.21 gm/dL, that warrants an investigation of the kidney function. If you are diabetic, it is all the more important that you consult your doctor, even though protein in urine by itself warrants seeing your doctor. ...Read more
Nothing Particular: It is one of those changes which has no clear cut medical implications. You can ignore it and you would not have to think about it or anything serious that I can medically relate it to. Good like ...Read more
No: Basically worthless. You're way too young for myeloma. Matt, you've been concerned about lymphoma for months. You're a smart guy at your mental and physical peak. There must be some bold, decisive actions you can take, with good guidance, to make your life better and more fulfilled, so that these concerns won't torment you. You deserve better. Best wishes. ...Read more
No worries: This is of no consequence. I would ignore it. ...Read more
Doesn't immunofixation test for the same things as protein electrophoresis and even more than protein electrophoresis?
It is not same test:
Serum protein electrophoresis (spe) is a screening test for myeloma and other paraproteinemias it simple shows the abnormal (m) protein peak.
Immunofixation is the next best test which provides a lot more additional information like the type of immunoglobulin which is causing the m spike and it will also tell us more useful info about further quantitation of the m peak and subtyping of your disease. ...Read more
Blood tests: They are two different separate blood tests, spep serum protein electrophoresis test is a screening test for plasma cell disorders like mgus, smoldering or full blown myeloma and quantitative igg is a blood test to quantify the amount of igg in blood. Usually more than 3 grams is significant in blood. ...Read more
Will the serum protein electrophoresis test tell me anything that the immunofixation test would not tell me?
Yes.: The ife is very sensitive at finding an abnormal antibody (monoclonal antibody) in blood, but it does not measure the quantity. The spep is less sensitive at finding the monocloprotein protein, but it is a quantitative test, so it answers "how much" monoclonal protein is present. The spep is used to monitor therapy for that reason. ...Read more
Doc wants to do protein electrophoresis test. Globulin always low and a/g always high. Could globulin just be low due to my igg3 deficiency, though?
Globulin production affects immunoglobulin
production, hence your low igg3 is a result of your low globulin level and this needs to be investigated. Your doctor is right. ...Read more
M58, could RA factor test rule out rhemetoid artheratis and protein electrophoresis, serum calcium, fbc, ESR rule out multiple myleoma up to some extnt?
See details: The ccp antibody is a more specific test for ra. 20-25% of people with RA have a negative rheumatoid factor. The protein electrophoresis is an important diagnostic test for myeloma but the diagnosis is really made through a bone marrow exam. A normal spep, however, rules out myeloma. ...Read more
What is the difference in the utility of these 2 tests: IgG subclass (1-4) serum blood test.......And......Serum protein electrophoresis?
Proteins: Igg is an immunoglobulin produced in the body to defends us from infection and inflammation, it is subdivided in 4 subclasses which all have different fucntions, the serum protein electrophoresis is going to measure the distribution of proteins in the blood to determine if there is an abnormal protein production. ...Read more