sometimes when i wake up my hands have a very strong itch what might this be

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sometimes when i wake up my hands have a very strong itch what might this be?

Rash?

Side_effects
Without any sign of a rash severe itching limited to the palms after sleep is unusual. Systemic meds could have it chi g as a side effect although localized itching to the palms is unusual. Try cold compresses in am and oral antihistamine at night before going to sleep.
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Dr. Victor Bonuel answered:

I have developed a skin irritation on my hand that has spread. It sometimes itches and oozes clear discharge. It gets really dry and splits.

Get checked for

Skin
eczema, contact/allergic dermatitis etc. Take care! http://www.m.webmd.com/skin-problems-and-treatments/features/dirty-dozen
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Dr. Jack Mutnick answered:

What could a few patches of itchy, bumps on my hand be? It itches sometimes more then other times,the bumps are quite small and they are clear.

Hives

Extremity-upper-hand
Hives are red, raised and intensely itchy mosquito-bite like bumps. If they do not resolve shortly, then see a doctor for further evaluation
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Dr. Jack Mutnick answered:

i have a rash on my hand that itches?

Dermatitis

Skin_rash
Also consider an elimination of any gloves, rubber/latex products, lotions, nail polishes, which are new or if you changed something recently.
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Dr. Payam Rafat answered:

If your hand itches and throbs what does it mean?

Many possibilities

Stringio
There are many things that could cause the skin to itch. Several types of inflammatory conditions of the skin, allergic reactions, sun exposure, insect bites, and sometimes bacterial, viral or fungal infections can cause rashes on the skin. Have it evaluated by a professional and get the appropriate treatment.
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Dr. Ronald Krauser answered:

What does it mean when your right hand itches all day ?

See details

Extremity-upper-hand
If there is not rash and the itching is limited to one hand, it probably means nothing. It could be related to stress.
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Dr. Yash K. Khanna answered:

What does it mean when your hand itches after a blood test?

Granulocytes

Blood
It is part of CBC and would include neutrophils,basophils and eosinophils. Other cells lymphocytes and monocytes are not granulocytes
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Dr. Jovita Anyanwu answered:

Werid rash on hand and wrist it itches but it.isn't blisters or bumpy?

Dermatitis

Rash
Hard to tell without seeing. Could be coming in contact with skin irritant . Sometimes such condition may respond to topical steroids.
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Little blood blister size of pen tip on hand itches a little bit what is it?

Have to see

Extremity-upper-hand
Not enough information, but a spider or bug bite is not unlikely. Good luck!
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Dr. Tracy Sinha answered:

Hives on both hands, small bumps and itches for no reason, what can cause this?

Palm or dorsal

Hives
if on palmer side R/O drug reaction. or Hyperhydrosis i.e block sweatglands , you can take claritine, wash hand often , 1% H-C cream or pure ALOE can help
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