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Doctor insights on: Sma 18 Lab Test

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus. All this needs to be correlated by your doc/specialist ...Read more

Dr. Barbara Lavi
4 doctors shared insights

Laboratory (Definition)

Is facility that provides controlled conditions in which scientific research, experiments & measurements are performed. An example is medical (clinical) lab where tests are done on clinical specimens in order to get info. About the health of a patient in terms ...Read more


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What are the tests for sma?

What are the tests for sma?

Different: Spinal muscular atrophy is diagnosed by genetic testing, muscle biopsy, electromyography (electrical muscle test). Superior mesenteric artery syndrome is diagnosed by x-rays, ultrasound, arteriography, ct scans. ...Read more

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Dear doctor lever function test as per the following normal: Ast: 19 2nd test alt: 34 in the SMA eday I made in it was ALT 41.5 1st test?

Dear doctor
lever function test as per the following normal:

Ast: 19 2nd test alt: 34
in the SMA eday I made in it was ALT 41.5 1st test?

Life is not exact...: Life is not exact, and neither are labs. The doctor can choose which values to believe, can average the values, and/or send the patient back to the lab for a repeat test. Lab results are just numbers; the doctor will decide what the numbers mean. ...Read more

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus. All this needs to be correlated by your doc/specialist ...Read more

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Abd pain with eating. All GI tests normal. Diagnosed with MALS via aortagram. Back blood flow in SMA and celiac stenosis. Might surgery help?

Abd pain with eating. All GI tests normal. Diagnosed with MALS via aortagram. Back blood flow in SMA and celiac stenosis.  Might surgery help?

MALS is: Characterized by abdominal pain attributed to compression of the celiac artery and possibly the celiac ganglia by the median arcuate ligament. The abdominal pain may be related to meals, may be accompanied by weight loss, and may be associated with an abdominal bruit. Treatment is generally surgical. Ref: https://en.wikipedia.org/wiki/Median_arcuate_ligament_syndrome ...Read more

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What types of conditions can an SMA -18 survey diagnose or suspect?

What types of conditions can an SMA -18 survey diagnose or suspect?

Chemical profile: As a screening tool, it has proved most valuable in picking up ongoing liver damage (meds, alcohol, hepatitis, iron, wilson's, metabolic syndrome), cholesterol trouble, hyperparathyroidism, diabetes, and kidney troubles. It's the main way we find these. ...Read more

Dan Tse Dr. Tse
4 doctors agreed:
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How common is sma?

Dan Tse Dr. Tse
4 doctors agreed:

1:6000 live births: Sma, or spinal muscular atropy is the second most frequent autosomal recessive disease, 1:6000 live born births. ...Read more

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What are the genetics of sma?

What are the genetics of sma?

More than one type: Spinal muscular atrophy of infants, before the gene was identified, was called Werdnig-Hoffman disease. Pitiful-we always looked at the tongues of floppy babies hoping it wasn't fasciculating. No treatment, breathing muscles progressively weakened, resulting in suffocation. 1 chance in 4 of recurrence-maybe. 2% were new mutations. Kugleberg-Weilander disease had onset after 12 mo. Now 10 forms. ...Read more

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Is SMA type II a congenital affliction?

Yes: Spinal muscular atrophy (sma) is caused by a mutation in the survival motor neuron gene 1 (smn1). Most of the time, parents are unaffected and the mutation newly appears in the affected child. ...Read more

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What is the lifespan of a child with SMA type 2?

What is the lifespan of a child with SMA type 2?

Depends: Sma ii usually appears between 6-18 months. Progression varies widely in this type of SMA with some patients falling to respiratory failure/pneumonia as children, while others can lead a full life into adulthood. ...Read more

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I was recently diagnosed with SMA 3, but I don't know if sxs I'm having are real or if I'm just being nervous. I don't want to bother my Dr with every little thing I feel. For example, I'm always tired?

SMA 3: Likley a result of the disease. You are deficient in a protein which affects nerves and so activity requires more effort/energy.

Smasupport.com is a website for individuals with SMA.as is www.curesma.org ...Read more

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How is SMA diagnosed?

How is SMA diagnosed?

See below: (spinal muscular atrophy) defining signs and symptoms are the first clue. To confirm diagnosis, a genetic test is done. If that is negative but the physician still things SMA is the cause of the patient's symptoms, an electromyography, enzyme creatnine kinase, and nerve conduction studies can be done. ...Read more

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Can you die from sma?

Can you die from sma?

Depends: Sma type 1, also known as infantile spinal muscular atrophy or werdnig-hoffmann disease, is the most common and severe type of sma. It typically presents in the neonatal period. Majority of affected infants die within a year from respiratory failure. Type 2, 3, and 4 present at a later ages and are milder forms. ...Read more

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What are the symptoms of sma?

What are the symptoms of sma?

Symptoms SMA: Areflexia, particularly in extremities
overall muscle weakness, poor muscle tone, limpness or a tendency to flop (the "floppy baby" syndrome)
difficulty achieving developmental milestones, difficulty sitting/standing/walking
in infants: adopting of a frog-leg position when sitting (hips abducted and knees flexed)
loss of strength of the pulmonary muscles: weak cough, weak cry. ...Read more

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What are the different forms of sma?

Question unclear: Your question needs more explanation.

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What is SMA Syndrome & can it be hereditary?

CongenitalTraumautic: Chronic — present from birth is congenital — either hereditary or a problem during gestation. Acute is a result of trauma. It's a rare, life-threatening gastro-vascular disorder. Complicated. Here's Wiki on it: https://en.wikipedia.org/wiki/SMA_syndrome

Ask you provider if you need help with it. Best! ...Read more

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How are patients with SMA cared for?

How are patients with SMA cared for?

SMA: Spinal muscular atrophy is a rare genetic disease affecting a protein in the spinal cord, leading to nerve death and muscular weakening and shrinkage. Caring for patients depends on the damage done and specific needs. Check the article in wikipedia for general information, and check with you physician for specific specialty referrals as needed. ...Read more

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Dan Tse
36 doctors shared insights

Sma (Definition)

Spinal muscular atrophy (SMA) ...Read more