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Doctor insights on: Sm Antibody

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Whats a normal level for sm antibody?

Whats a normal level for sm antibody?

Depends on whose sm: Different labs have different ranges for their positive test. They usually set the range for detection at a certain level. Below that level they have many people without lupus that would have a + test. Above that level is what they call a + test. But not all labs are created equal - so each has there own level determined by their scientific investigations. ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Whats a normal level for sm antibody?

Depends on whose sm: Different labs have different ranges for their positive test. They usually set the range for detection at a certain level. Below that level they have many people without lupus that would have a + test. Above that level is what they call a + test. But not all labs are created equal - so each has there own level determined by their scientific investigations. ...Read more

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What is a normal level for sm antibody?

Negative: Normal people do not have antibodies to sm antigen. It is one of the markers for lupus. ...Read more

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Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus?n

See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more

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What is a positive SM antibody blood test for SLE?

What is a positive SM antibody blood test for SLE?

Marker for SLE: Systemic lupus erythematosus can exist without a positive test result but a positive result =SLE. This is not a happy Dx, but some people are well managed by good treatment and compliance w/ recommendations for how to live. A specialist Health Psychologist is often a great asset in learning how to deal w/ the condition and symptoms that can include and/or cause emotional problems. Best! ...Read more

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What is considered a positive result for the SM antibody for SLE? My Ana 1:320 but DNA was negative. So many blood tests for SLE diagnosis!!

What is considered a positive result for the SM antibody for SLE? My Ana 1:320 but DNA was negative. So many blood tests for SLE diagnosis!!

SLE: hi, diagnosis of SLE is not base on blood test, positive DsDNA and ANA are just one out of 11 criteria for diagnosis of SLE, to diagnose SLE you need to have 4 out of 11 criteria. ANA is a non- specific test and false positive rate is high, especially in women and elderly. ...Read more

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The only pos blood test I have is ANA of 1:320. Neg RF CCP DNA and SM antibody was low of 10. Extreme joint pain 6 mnth. RA, lupus, or neither?!

+ ANA: There are other spondyloarthropathy that can cause a lot of pain and will require treatment. Did they do an HBLA27 test? Make sure you f/u with your rheumatologist. If you have RA you can get these results. You may need to start a biologic medication. Good luck and feel better soon) ...Read more

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Had lab test done. Sm/rnp antibody 2.5 pos. What does this mean?

Had lab test done.  Sm/rnp antibody   2.5 pos.   What does this mean?

Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place? ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more