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Doctor insights on: Sm And Sm Rnp Antibodies

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If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do? (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

If I have a high positive ANA (1:640) speckled, nucleolar and low positive SMA (1:40), what further tests do I need to do?  (Negative SS-A, SS-B, Smith, RNP, SCL-70, Anti Jo Abs)

? anti dsDNA: You've probably already had these more basic tests: complete blood count, sedimentation rate, C-reactive protein, urinalysis & rheumatoid factor. It appears to me that the ANA results with slight positive anti-Smith may suggest lupus; you need an antibody to double-stranded DNA (anti dsDNA) which is very specific & somewhat sensitive for lupus.All this needs to be correlated by your doc/specialist ...Read more

Antibody (Definition)

An antibody is a protein the body's immune system makes to identify potentially harmful substances in the body. Antibodies attach to the substance on a molecular level and mark it so the immune ...Read more


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Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Sm/rnp antibody- ANA choice- positive, speckled/titer: 1:1280; sm & rnp (done alone) negative; sm/rnp antibody (together?) positive 3.0 guessing mctd?

Heads up: One of the things that's frustrating about these antibody tests looking for different connective tissue diseases is that they are difficult to do and are fraught with pitfalls. I suspect you've had at least one lab error to complicate your workup. Have you have a tube test for u1-rnp? Your clinical symptoms and signs actually tell more about your diagnosis ; best direction for treatment. ...Read more

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Had lab test done. Sm/rnp antibody 2.5 pos. What does this mean?

Had lab test done.  Sm/rnp antibody   2.5 pos.   What does this mean?

Probably nothing: That low titer is not impressive, usually the RNP. Ask the doctor who ordered it. Why was the test ordered in the first place? ...Read more

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I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

I'm having negative DNA ,Sm and Rnp antibodies, but positive sm/rnp antibody,and high ANA titre speckled,so what is the diagnosis ?

Lupus: These serologies are rather non specific. The speckled ANA is non specific. In Systemic Lupus Erythematosis (SLE) it is usually homogeneous in its staining. Anti-Sm and Anti RNP can be see in mixed connective-tissue diseases and overlaps with SLE, scleroderma and myositis. As often is the case a specific diagnosis cannot be made. You need to see a Rheumatologist. ...Read more

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Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus?n

Positive ANA....Positive SM Antibody of 39 units....Positive RNP of 32 units. What would these numbers mean in comparison to tiers or to Lupus?n

See below: SM antibodies are specific for systemic lupus and are often associated with anti-RNP antibodies. They are commoner in Blacks and Asians. It is not an indicator of severity or predictor of organ involvement, which requires careful history, physical and other tests, preferably in the hands of a certified rheumatologist. ...Read more

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Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B, RNP and SM. Lupus?

Ana went from 1:80 spck to negative, VHS went from 50 to 10mm in 1week. Negative anti-dsDNA, Antibodies to Ro/SS-A and La/SS-B,  RNP and SM. Lupus?

Probably not : A low level ANA can be seen as a auto immune phenomenon of Hashimoto's thyroiditis (which I see you have). The specific lupus tests are (-). Joint pain without joint swelling is not a reliable diagnostic finding for lupus. ...Read more

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Blood tests showed high antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere. Is this likely lupus or a different automimmune?

Blood tests showed high  antibodies to: ana, ssdna, sm, rnp/sm, ssa(ro), ssb(la), scl-70, centromere.  Is this likely lupus or a different automimmune?

Prob false positive: To have all these antibodies to be positive is suggestive of a false positive result. Virus infection can cause similiar findings. Ultimately these results have to be interpretted in the context of your doctor's findings. Talk to your doctor. ...Read more

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What is the definition or description of: rnp antibody?

Anti-RNP: http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357.

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Dr. Krishna Kumar
76 doctors shared insights

Rnp Antibody (Definition)

http://www.mayomedicallaboratories.com/test-catalog/clinical+and+interpretive/81357. ...Read more