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Doctor insights on: Slightly Elevated Ca 125

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Dr. Jane Van Dis Dr. Van Dis
Obstetrics & Gynecology
14 years in practice
Sanford School of Medicine of the University of South Dakota
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Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Hi, I'm 48 yo, have endometriosis, ovarian cysts, uterine fibroids, pre-menopausal. CA 125 was around 200's then 159 the last one was 210 any concerns?

Likely, no: CA 125 is not recommended as a screening tool for ovarian cancer when used in risk-based stratification. Meaning, assuming that your mom or sister didn't get diagnosed with ovarian cancer. Normal for women with endometriosis to have elevated CA-125. It sounds like your doctor has done Ultrasound to evaluate ovaries as well. Your MD knows your history and risk, likely this CA-125 level is normal

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Dr. Amrita Dosanjh
126 Doctors shared insights

Ca125 (Definition)

Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast ...Read more


Dr. Vicken Poochikian Dr. Poochikian
Internal Medicine
38 years in practice
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Ca-125 was elevated at 40? Once told by gyno that I have precancerous cells. Should this combination worry me?

Yes!: Ca125 is a cancer marker. If elevated is something to worry, even though its not specific. If you were told to have a precancerous lesion, wherever it was, needs to be reevaluated.

Dr. Richard Reams Dr. Reams
Family Medicine
years in practice
The University of Iowa Roy J. and Lucille A. Carver College of Medicine
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Can Lyme disease cause an elevated CA125 reading?

Unknown: At this point in time there is a lot of discussion about this topic and many who feel there may be some association but there has been no known proof of an association of Lyme disease and an elevated CA 125. This is still being researched and nothing that can say a definite cause and affect. Hope this helps.

Dr. Lewis Hassell Dr. Hassell
Pathology
35 years in practice
University of Utah School of Medicine
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Should I be concerned about elevated ca-125 of 132 if I have a history of benign cysts?

CA-125: This marker is quite non-specific for cancer, particularly in pre-menopausal women. Any things that irritate the lining of the abdomen (such as cysts, endometriosis, and non-ovarian things as well) can prompt elevations in the range you have noted. Other means of screening for cancer however are also imperfect. If you are at high risk, other follow-up may be needed.

Dr. Herbert Duvivier Dr. Duvivier
Internal Medicine - Hematology & Oncology
29 years in practice
Tufts University School of Medicine
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3 plus white cells in urine and ca125 elevated related?

Probably not but...: Here is a possibility; ca125 (a bad screening test for ovarian cancer due to its lack of specificity) can become elevated with any inflammatory condition of the peritoneal lining of the abdomen. If the WBC in the urine reflect a UTI or infection of the kidney then it is possible the ca125 could be elevated.

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Dr. Carlo Contreras Dr. Contreras
Surgery - Oncology
14 years in practice
Northwestern University Feinberg School of Medicine
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My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

My ca 125 blood test result slightly elevated, with a different reading 3 times, what could cause this to happen?

Many causes: The ca-125 blood test is very sensitive-- in many cases it is too sensitive. In certain cases, it can be a marker of certain types of cancer. But in other patients, a modestly elevated ca-125 is not alarming. Visit with your doctor to better understand the details of your case.

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Dr. Brian Lawenda Dr. Lawenda
Radiation Oncology
20 years in practice
Temple University School of Medicine
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Does an elevated ca 125 level always indicate that ovarian cancer is present?

Does an elevated ca 125 level always indicate that ovarian cancer is present?

No: Ca-125 may also be elevated in other cancers (i.e. Endometrial, fallopian tube, lung, breast and gastrointestinal cancers.) it can also be elevated with endometriosis or any inflammatory condition in the abdominal area.

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Dr. Ed Friedlander Dr. Friedlander
Pathology
40 years in practice
Northwestern University Feinberg School of Medicine
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I have endometriosis (ovarian cyst). Does the CA125 results be a little elevated because of that?

Yes: Ca125 is often up a bit for no obvious reason. Reference range is set so that several percent of healthies fall outside.

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Dr. Carlos Encarnacion Dr. Encarnacion
Internal Medicine - Oncology
31 years in practice
University of Puerto Rico School of Medicine
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What does it mean when you have mildly elevated ca 125? I have a 15cm ovarian cyst. Does that mean its cancerous?

Nothing out of..: ...Context. Ca.125 is used to follow up response to treatment in patients with cancer of the ovary but a slightly elevated level can come from non malignant causes (and it can be normal even if there is cancer). It is not considered a screening test. Whoever ordered it probably had very valid reasons to do so and I'm sure he/she can explain its implications to you in the proper context. Best 2u.

Dr. Richard Orr Dr. Orr
Surgery - Oncology
40 years in practice
University of South Florida College of Medicine
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My ca125 levels are slightly elevated and there is a solid mass on my ovary, should I be concerened that it is ovarian cancer?

Depends: Ask your gyn. A solid mass is concerning, but your age, menopausal status, and the ultrasound characteristics are important as well. Elevated ca-125 suggests ovarian cancer, but may be somewhat elevated in many benign conditions, as well, including endometriosis. All of this needs a discussion with your gyn and a possible referral to a gyn oncologist - who are the real experts in this area.

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Dr. Thomas Namey Dr. Namey
Internal Medicine - Rheumatology
44 years in practice
Washington University School of Medicine
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Is possible that ca125 to be elevated in an abdominal sarcoidosis (peritoneal, hepatic sarcoidosis plus ascites)?

Is possible that ca125 to be elevated in an abdominal sarcoidosis (peritoneal, hepatic sarcoidosis plus ascites)?

No association!!: Something else is causing this. And abdominal sarcoid is extraordinarily rare. Crohn's is more likely to do cause abdominal and hepatic granulomata, but neither are associated with increased ca125.

Dr. Jane Van Dis Dr. Van Dis
Obstetrics & Gynecology
14 years in practice
Sanford School of Medicine of the University of South Dakota
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7 CM ovarian cyst, ca-125 levels elevated (48), roma score & all blood tests good. Previously had nasopharyngeal cancer. Recurrence or endometrioma?

Likely endometrioma: At your age, ovarian cancer would be exceedingly rare. Ca-125 levels can be elevated in young women for a variety of reasons that have nothing to do with cancer. Nasopharyngeal cancer and ovarian have no relation to each other. Your doctor should tell you what features or characteristics the ovarian cyst has, this will tell you what kind of cyst it is. Good luck!

Dr. Wayne Ingram Dr. Ingram
Obstetrics & Gynecology
years in practice
Wayne State University School of Medicine
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My CA 125 elevated to 478. I am 20 years. My doctor has diagnosed from a TVUS scan that I have many ovarian cysts on my both ovaries. Is it a cancer?

Ovarian biopsy: CA 125 blood studies are notoriously inaccurate predictors of ovarian cancer and an ovarian tissue biopsy is needed to answer your question.

Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
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Where does ca125 originate?

In the peritoneal li: It arises from the irritation or growth of peritoneal lining cells. These cells also cover the ovaries. So ca 125 is often used as a test to screening for ovarian cancer. But it often raised in any conditions causing intra -abdominal irritation like in peritonitis.

Dr. PHILIP WALLER Dr. WALLER
Internal Medicine - Rheumatology
29 years in practice
Loyola University Chicago Stritch School of Medicine
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What is a normal reading for a ca125?

Quest: Quest lab has a value below 21 u/ml as normal.

Dr. Michael Thompson Dr. Thompson
Internal Medicine - Hematology & Oncology
16 years in practice
Mayo Clinic College of Medicine
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What is the definition or description of: ca125?

What is the definition or description of: ca125?

CA125 Definition: Ca-125 (cancer antigen 125 or carbohydrate antigen 125) is a biomarker/tumor marker for ovarian cancer (etc); however, it is not sensitive or specific enough to use as a screening test. Also, a uk study showed that treating based on ca125 level did not improve outcomes. "125" comes from the 125th attempt to develop a marker. It was introduced by bast et al. In 1983.

Dr. PHILIP WALLER Dr. WALLER
Internal Medicine - Rheumatology
29 years in practice
Loyola University Chicago Stritch School of Medicine
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How concerned should I be if my ca125 level was not ordered this year?

How concerned should I be if my ca125 level was not ordered this year?

None to minimal: If the ca-125 was going to be used simply as another blood test for example in a yearly physical, you should not be terribly concerned at all. My answer is different however, if you have a history of a disease such as ovarian cancer and that it should be checked. I also might order it if you have a strong family history of ovarian cancer for example. If not you should not be concerned.

Dr. Mazen Ghani Dr. Ghani
Radiology
20 years in practice
Central University of the East School of Medicine (UCE)
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What is the ca-125 test?

CA-125: Cancer antigen 125 (ca-125) is a protein found on the surface of many ovarian cancer cells. It also can be found in other cancers and in small amounts in normal tissue. A ca-125 test measures the amount of this protein in the blood and can be used as a tumor marker.

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Dr. Sewa Legha Dr. Legha
Internal Medicine - Oncology
46 years in practice
Punjab University, Christian Medical College
20

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What causes my ca 125 to go up?

Many causes: It is commonly elevated in ovarian cancer. But it can go up from any reason which causes irritation of the peritoneal lining of your abdomen which includes some benign conditions too. It depends on the level and also if it is going up steadily or staying elevated but stable and not increasing. Your gynecologist can help you to sort it out.