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Doctor insights on: Skin Cancers And Tamoxifen

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What is tamoxifen and why is it used in cancer research?

What is tamoxifen and why is it used in cancer research?

Estrogen blocker: Hi. Tamoxifen is an estrogen receptor antagonist. Certain cancers (most notably estrogen receptor-positive breast cancer) are stimulated to proliferate in response to estrogen, and blocking estrogen action at its receptor or blocking estrogen production by blocking the aromatase enzyme have been shown to be very therapeutic. Tamoxifen is not useful in cancer research that does nor involve estrogen ...Read more

Dr. Barry Rosen
4,224 doctors shared insights

Cancer (Definition)

Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more


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What is tamoxifen and why is it used in cancer research?

What is tamoxifen and why is it used in cancer research?

Estrogen blocker: Tamoxifen is a drug which blocks estrogen receptor. Cancers which express high levels of estrogen receptor, such as some breast cancers, may respond well (shrink) to tamoxifen. It has been in clinical use for decades. ...Read more

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What is the use of baking soda for cancer, will it neutralize the effect of tamoxifen?

What is the use of baking soda for cancer, will it neutralize the effect of tamoxifen?

I'm sorry: I expect that even the members of the healthtap team who are most sympathetic to alternative / complementary medicine will agree that the "pop" claims about affecting the biologic behavior of cancers by eating baking soda will tell you it is without any basis in fact. I autopsied one person who died from eating too much baking soda at once. Don't do it. ...Read more

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I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

I was wondering what would happen if someone took tamoxifen if you didn't have breast cancer?

May surprise you but: ...Folks with high risk for breast cancer (without cancer) can take it to reduce their risk. It's not for everybody and should be done under the care of a specialist in the field. Anybody else will get the side effects (hot flashes and increased risk for blood clots and uterine cancer) for no gain at all. ...Read more

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Is there an effective substitue for tamoxifen as post cancer treatment?

Is there an effective substitue for tamoxifen as post cancer treatment?

Yes: Depending on the menopausal status other drugs can be used. For premenopausal women toermifine can be used if necessary. In postmenopausal women aromatase inhibiotrs such as anastrozole, letrozole, etc can be used. ...Read more

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What are your thoughts of the use of tamoxifen for refractory ovarian cancer?

What are your thoughts of the use of tamoxifen for  refractory  ovarian cancer?

Little: Probably not very beneficial. For uterine cancer, there has been some data. Little if any benefit in ovarian cancer. Unlike breast cancer in which there is a benefit in estrogen positive disease because of the estrogen target, there is no target in ovarian cancer. Hope this helps. ...Read more

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Brast cancer and mastectomy;1/12 affected node;6sessions chimio;5weeks radio;5years tamoxifen .. What do you think abt this situation ?

Brast cancer and mastectomy;1/12 affected node;6sessions chimio;5weeks radio;5years tamoxifen  .. What do you think abt this situation ?

Sounds reasonable: You have described a fairly typical regimen of breast cancer treatment, although the post mastectomy radiation indicates, to me, that you had some advanced disease. You need to optimize your lifestyle. Eat right, get your rest, maintain contact with your medical team, and don't let your cancer define you. Enjoy your life, and surround yourself with positive people. Good luck. ...Read more

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Why women taking Tamoxifen suffer from the risk of developing other cancers of the reproductive tract in comparison to all other women ?

Why women taking Tamoxifen suffer from the risk of developing other cancers of the reproductive tract in comparison to all  other women ?

Hormone effect: In the breast tamoxifen blocks any estrogen activity but in the uterus it is just the opposite where tam stimulates the uterine lining just like estrogen. This can causes overgrowth of the lining (endometrial hyperplasia) which is a risk for cancer. The same risk is present with hormone replacement with estrogen only which is why progesterone needs to be given as well with HRT. ...Read more

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Is tamoxifen effective only if the cancer has not spread outside of the breast?

Is tamoxifen effective only if the cancer has not spread outside of the breast?

On the Contrary: Tamoxifen is a very effective drug for the treatment of hormone-sensitive (estrogen receptor +) breast cancers that has spread outside the breast. It may be used alone or in combination with traditional IV chemotherapy, depending on the cancer stage. Furthermore, tamoxifen has been shown to be effective reducing the chance of developing breast cancer in high-risk women ("chemoprevention"). ...Read more

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Dr. Sean Canale
638 doctors shared insights

Tamoxifen (Definition)

This medication is used to: treat breast cancer that has spread to other parts of the body in men and women. Treat early breast cancer in women who have already been treated with surgery, radiation, and/or chemotherapy. Reduce the risk of developing a more serious type of breast cancer in women who have had ductal carcinoma in situ (dcis; a type of breast cancer ...Read more