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Doctor insights on: Skin Biopsy Results For Lupus

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How accurate is a skin biopsy for lupus? Can you have a false/ positive test result?

How accurate is a skin biopsy for lupus?  Can you have a false/ positive test result?

Lupus biopsy: Biopsy of lupus has a number of features that lead to diagnosis: a thickened basement membrane, vacuolar alteration of basal keratinocytes and superficial and deep inflammatory infiltrate. Lupus has a number of different forms in the skin and there are times when it is not easy to differentiate it from other types of skin inflammation. There are other tests to support diagnosis. ...Read more

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Dr. Patrick Sweet III
111 doctors shared insights

Skin Biopsy (Definition)

A skin biopsy is a way of getting a sample of skin for diagnostic purposes. There are two main ways of doing this. Shave biopsy. A blade is used to cut across the skin. It can leave a scar a bit like a golf divot. Punch biopsy. A device that looks like a little cookie cutter is used to take a cylinder of skin. This goes all the way through the skin and is ...Read more


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Can you do a skin biopsy for lupus with no rash and it be positive for lupus?

Can you do a skin biopsy for lupus with no rash and it be positive for lupus?

Possible: Would require getting a location that has the characteristics of lupus on examination. Not sure of the odds, but it would be possible. ...Read more

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I have symptoms of behcets and lupus.Neg ana, but positive lupus skin biopsy. Could i still have lupus?

I have symptoms of behcets and lupus.Neg ana, but positive lupus skin biopsy. Could i still have lupus?

Unlikely: Technically yes, but practically no, at least not the systemic form. I cannot remember the last time i saw ANA negative systemic lupus but anything is possible. ...Read more

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Can you be diagnosed with lupus with +ana homogenous pattern, inflammation shown in skin biopsy and symptoms that all point to lupus?

Can you be diagnosed with lupus with +ana homogenous pattern, inflammation shown in skin biopsy and symptoms that all point to lupus?

It depends: Nobody knows what lupus actually is, so it's diagnosed by criteria. http://www.rheumtutor.com/2012-slicc-sle-criteria/ i need to give you 2 heads-up -- homogeoneous ANA pattern may be a lab error, and people who think they have lupus but don't meet the criteria tend to have a favorable prognosis. Wishing you the best -- the "brain fog" does make me think of lupus. Be strong ; stay proactive. ...Read more

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Would a skin biopsy for lupus still come up positive, even without a malar rash?

Would a skin biopsy for lupus still come up positive, even without a malar rash?

It can: There are many types of rash that can be seen in lupus. While the mal;ar or butterfly rash is the most common there are other lesions including the discoid rash of lupus. Many other rashes are also described as being seen in lupus. Even normal appearing skin can be positive for lupus using special stains and techniques. ...Read more

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Does cutaneous lupus always present with positive ANA? What other tests besides skin biopsy can tell?

See below: There is no single test for lupus. A person can have lupus without ANA. The following website provides information about diagnostic criteria for lupus. May I add that there experts for such disease at UPMC in Pittsburgh. http://forums.webmd.com/3/lupus-exchange/resource/26 ...Read more

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Skin biopsy on butrfly rashto dx? +ana 1:64, bilat joint pain photo sens, slightly elevated alpha 1 & 2?. Dbl strand ANA neg sed =1, -- lupus or not?

Skin biopsy on butrfly rashto dx? +ana 1:64, bilat joint pain photo sens, slightly elevated alpha 1 & 2?. Dbl strand ANA neg sed =1, -- lupus or not?

See below: It could be but without seeing the skin biopsy, performing an exam, and looking at the rest of your lab work, i can't make the call---only your treating physician can diagnose you. ...Read more

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Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy give more definitive diagnosis?

Recent diagnosis w/autoimmune disease & skin biopsy result: urticaria or mast cell disease. Shouldn't biopsy  give more definitive diagnosis?

Hard to tell: Mast cells are the cells that release histamine in the body. This is what happens in urticaria, so one will see mast cells in biopsies of urticarial (hive-like) lesions. Mast cells can also be found in increased numbers in people with mastocytosis. Thus the biopsies may be similar. As stated by my colleague, the clinical history can be key to the diagnosis. Talk with your doc. ...Read more

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Dr. Hirenkumar Italia
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Biopsy (Definition)

Biopsy is tissue removed by needle or cutting to remove part of a body part. It is usually a small amount of material that is processed by a pathologist. Most of the time it is stained and looked at through a microscope to arrive at a diagnosis. Special processes are done for some tissues or problems. The purpose is to tell what the problem is (diagnosis). ...Read more