Doctor insights on:
Doxepin: Doxepin (sinequan) is an old antidepressant used for major depression. It is now reintroduced in very low dose to help sleep, due to its sedative effect. Symbiax is combination of Prozac & zyprexa, (olanzapine) used for depression with psychotic features, and is very sedating & causes weight gain. ...Read more
What is difference doxepin (silenor) & (sinequan)? What is dosage for insomnia for both types? Why both called doxepin? Seem very different.
Doxepin = generic : Silenor and sinequan are both doxepin, the generic name for the medication. The only difference is the dosages. Silenor comes in 3 and 6mg strengths, but sinequan's smallest dose increment is 10mg -- and it's a capsule which can't be cut in half. Sinequan is fda-indicated for depression, not insomnia. Prescribing sinequan for sleep is an "off label" use; giving silenor is an indicated use. ...Read more
TCA vs neuroleptic: Sinequan is the brand name for doxepin, available generically for many years. It's a very sedating tricyclic antidepressant, now used mostly as a sleep aid. Seroquel is the brand name for quetiapine, available generically in the us since march 2012. An antipsychotic & mood stabilizer, it's also quite sedating. However, seroquel's potential medical risks argue against using it for sleep alone. ...Read more
I am six weeks pregnant and take melatonin at night for sleep. Is melatonin safe during pregnancy? My doctor just took me off sinequan (doxepin) for sleep.
I have tried 25 different medications for depression since 1982. Sinnequan only worked twice with bad side effects but then stopped working in 1995.
Depression: You're not the only one with the same problem. A couple of considerations - first, there's a chance it may not be just depression. Chances are it's more than depression. Secondly, if it is depression, it's not just about medication to treat it. There must be a comprehensive approach to it - psychotherapy, support group, etc. I find that people would rather take a pill without resolving the cause. ...Read moreSee 2 more doctor answers