Doctor insights on:
Sinemet Overdose Symptoms
I have been on sinemet (carbidopa and levodopa) for years for dopa responsive dystonia. It has resolved all my symptoms. I am 60 yr old and I am considering botux injections for wrinkles. Would the botux affect my drd?
Yes can be a problem: Botox is what is known as an anticholinergic medication. The combination between Dopamine (or perhaps in your case sinemet (carbidopa and levodopa) or carbidopa/levodopa) can actually either enchance or reduce the activity of the dopamine. Botox can also exacerbate the condition known as tardive dyskinesia because of its ability to deplete stores of Dopamine in the brain. ...Read more
I started symptoms of parkinsons. Loss of smell almost total now. Ridgity and loss of balence has gotten worse. Would isradipine help. Sinemet (carbidopa and levodopa) helped.?
Maybe, see below.: Isradipine has had some small studies that suggest it might be helpful, but we really don't know. There are many other medicines out there that are fda approved that will help more. Sinemet as you mentioned is one. Other medicines include the Dopamine imposters such as mirapex, requip, and neupro (rotigotine). I would recommend one of these before trying isradipine, which may not do much symptomatically. ...Read more
Carbidopa/levodopa: Sinemet (carbidopa and levodopa) is a combination drug that contains Carbidopa and levodopa. It is most commonly prescribed for parkinson's disease but may also be prescribed for other conditions including restless legs syndrome. ...Read more
Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more
See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read more
Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more
Variable, but: In my experience, the maximum Sinemet (carbidopa and levodopa) dosing is the 25/250 tab four times daily, and if this seems to wear off, one can add Comtan (entacapone). Problem with going too high with L-DOPA is incidence of dyskinesias. ...Read more
Yes: But the GI side effects would make it intolerable. ...Read more
It depends: Because of cost considerations its worth trying it for a while. Watch for peak dose dyskinesis and dose failures or wearing off. ...Read more
Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more
Dosages: Dosages are adjusted for the specific needs of each patient - there is no standard dose for any specific time period. Sinemet (carbidopa and levodopa) comes in carbadopa-levodopa doses of 10-100, 25-250, and 25-100. These can be combined and given at various times throughout the day to best relieve the symptoms of parkinson's disease. If you are not sure of your dose or the dose of someone you are caring for, you need to call the doctor that prescribed the medication to clarify. Good luck! ...Read more
On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree with my diagnosis of pd.?
See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read more
When switching from regular Sinemet (carbidopa and levodopa) to CR, do you need to add little more CR to achieve the same dose of the regular Sinemet (carbidopa and levodopa)?
Not usually: You can usually use the same dose of Sinemet (carbidopa and levodopa) CR as you had of the regular Sinemet (carbidopa and levodopa). You may not feel it "kick in" as strongly but it should work just as effectively and hopefully last longer for you. Good luck. ...Read more
Slowly: Depends on dosing/schedule, but its very important to taper very slowly. It would be best to call your prescribing doctor and have them give you a clear tapering schedule. ...Read more
Before I take Stalevo, (carbidopa and levodopa and entacapone) I'm on but shortly after, I suddenly go off. What's causing this?
See a physician: Your questions is not very clear, but is important to see your doctor for accurate reason for your symptoms ...Read more
Parkinson patient for 7 years currently taking sinemet & requip (ropinirole). Only sinemet seems to releive systoms. Is there any risks of stoping requip (ropinirole)?
See neurologist: The Requip (ropinirole) may not be playing much of a role at this point, and could be tapered off over a few days. There really is no substantial withdrawal issue usually, and unlikely to experience any challenges. Discuss with your doctor, and revamp your medications, as dbs will certainly change your med needs. ...Read more
I took ten tylenol (acetaminophen) and then I took sinemet, benztropine, clonazapan, serquel. Will this kill me?
Did you take:
Multiple pills of each? If you are having
thoughts about killing yourself, get seen at the nearest emergency room now. Have a friend or relative drive you or call 911 for emergency services for transport. You can call the National suicide hotlines 24/7 at 1-800-suicide (1-800-784-2433) or 1-800-273 – talk (1-800-273-8255) for support. ...Read more
Is Stalevo (carbidopa and levodopa and entacapone) superior to Sinemet for Parkinson’s? Is one better than the other?
Superiority?: All of the drugs in this class attempt to increase the levels of circulating dopamine. Sinemet is a combination of 2 drugs whereas Stalevo (carbidopa and levodopa and entacapone) is a combination of 3. There is currently an ongoing study at the Mayo Clinic to answer this question - but right now - there isn't any data to demonstrate if one is 'better' than the other. The best treatment is the one that works for you. Hope that helps! ...Read more
What is the protocol for switching a Parkinson’s patient from regular Sinemet (carbidopa and levodopa) to Sinemet (carbidopa and levodopa) CR?
Slow increase: Sinemet (carbidopa and levodopa) CR is a 2x/day treatment vs Sinemet (carbidopa and levodopa) at 4x/day, so to get to twice the daily dose you need to increase dosing slowly over several days, up to a week. I suggest you talk to your doctor, who can nap out a plan to do this safely ...Read more
What’s the usual reduced sinemet dose given for a parkinson patient after dbs surgery after being on sinemet for 7 years? Feel under medicated after surgery. Sinemet was reduced to half tablet 25/100
Sinemet (carbidopa and levodopa) dosing:
Sinemet (carbidopa and levodopa) is a medication composed of two different complimentary medications.
It is often used to treat movement disorders including tremor, rigidity, and what is called bradykinesia.
The dose of sinemet (carbidopa and levodopa) depends upon what the medication is being used for and this needs to be determine in consultation with your physician. ...Read more
Slow taper: If sinemet (carbidopa and levodopa) needs to be stopped, depending on the amount and indication for the medication, the most desire able way is to taper the medication. Parkinson's patients can have severe side effects if sinemet (carbidopa and levodopa) is abruptly stopped. ...Read more
Probably not bad: I had to look up rhodiola as that was one I had never heard of. There are no reasons, at least theoretically, that the two should be a problem. I did a literature search and there are no articles in the medical literature looking at rhodiola and sinemet (carbidopa and levodopa). There are some laboratory papers that suggest rhodiola should be helpful in pd, but I could not find any clinical studies in people. ...Read more
Depends...: Regretfully, there is no typical Sinemet (carbidopa and levodopa) dose following DBS, given that each patient is different and their need for treatment varies. Discuss this with your neurologist. ...Read more
Typical- Misnomer...: Quite honestly, as a neurologist I've found LESS AND LESS TYPICAL starting doses of any of the anit-parkinsonian medications as I get farther into my career. Oh, sure there are textbook numbers but when the actual DIAGNOSIS of PD cannot be firmly made at times for years after presentation should there really be such as a thing as a TYPICAL starting dose of Sinemet (carbidopa and levodopa)? Commonly seen is 25/100 3x/day. ...Read more
Sometimes: Sinemet (carbidopa and levodopa) should be tapered slowly over many weeks to months foll. The combination of DBS and meds usually works better than either alone. There may be some sinemet (carbidopa and levodopa) reduction with a single DBS, and even more with a second DBS. The target allowing the most med reduction is STN. Every patient needs a different approach and everyone is different so it is hard to say how much it can be reduced. ...Read more
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