Doctor insights on:
Dosages : Dosages are adjusted for the specific needs of each patient - there is no standard dose for any specific time period. Sinemet (carbidopa and levodopa) comes in carbadopa-levodopa doses of 10-100, 25-250, and 25-100. These can be combined and given at various times throughout the day to best relieve the symptoms of parkinson's disease. If you are not sure of your dose or the dose of someone you are caring for, you need to call the doctor that prescribed the medication to clarify. Good luck! ...Read more
Is it safe to take fluoxetine with Parkinson's medications such as sinemet and requip (ropinirole)?
Mild interaction: There is no severe interaction although if the fluoxetine were to be sedating to you then you may feel somewhat sedated. Additionally, the selective serotonin reuptake inhibitors that include fluoxetine have been known to produce mild extrapyramidal effects through obscure mechanisms. This would translate into a potential for mild motoric phenomena that would be only a nuisance. Stay safe! ...Read more
What is the difference between Parkinson's drug sinemet and stalevo (carbidopa and levodopa and entacapone)?
COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo (carbidopa and levodopa and entacapone) is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa. ...Read more
My mom, Safia, 60 years old, resident of Pakistan has drug induced parkinsonism, which is bothering a lot & worsening. Sinemet (carbidopa and levodopa) 25/250 every 4.5 hours?
Tachyphylaxis.: Dosing of Sinemet (carbidopa and levodopa) is a little strange, requiring front loading in the day and a long gap at night without dosing. If taken like most other medications, on a more regular dosing interval, tachyphylaxis develops, which essentially means the efficacy of the medication reduces. ...Read more
Is it safe to take clonazepam for sleep with sinemet (carbidopa and levodopa) for Parkinsons patient? Are there any drug interactions?
Probably safe...: ...but not especially the best choice! Although medications in that class (benzodiazepines) allay anxiety and can relax muscle spasm, they also interfere with normal sleep architecture and increase the risk of falling. I would certainly advise that you discuss this with your neurologist or a psychiatrist trained in sleep disorders or with additional training in geropsychiatry. ...Read more
Sinemet-CR: This has to be determined by careful titration thru your doctor. Initial dose is usually 50-200. Consult your Neurologist. ...Read more
See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read moreSee 1 more doctor answer
Sinemet (carbidopa and levodopa): Not sure what milligram each, but if that's what your doctor prescribed & your symptoms are under control & you are tolerating the medication well, then you should be ok. ...Read more
Yes: But the GI side effects would make it intolerable. ...Read more
It depends: Because of cost considerations its worth trying it for a while. Watch for peak dose dyskinesis and dose failures or wearing off. ...Read more
Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more
On sinemet (carbidopa and levodopa) 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree
with my diagnosis of pd.?
See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read moreSee 1 more doctor answer