Doctor insights on:
Sinemet Drug Interactions
Is it safe to take clonazepam for sleep with sinemet for Parkinsons patient? Are there any drug interactions?
Probably safe...: ...but not especially the best choice! Although medications in that class (benzodiazepines) allay anxiety and can relax muscle spasm, they also interfere with normal sleep architecture and increase the risk of falling. I would certainly advise that you discuss this with your neurologist or a psychiatrist trained in sleep disorders or with additional training in geropsychiatry. ...Read more
COMT inhibitor: Entacaptone is a selective catecholamine-o methyl transferase (comt) inhibitor that increases the bioavailabilty of dopamine. Like Carbidopa in sinemet it does not cross the blood brain barrier. Stalevo is a combination of l dopa, Carbidopa and entacaptone. Sinemet is a combination of Carbidopa and l-dopa. ...Read more
My mom, Safia, 60 years old, resident of Pakistan has drug induced parkinsonism, which is bothering a lot & worsening. Sinemet 25/250 every 4.5 hours?
Tachyphylaxis.: Dosing of Sinemet is a little strange, requiring front loading in the day and a long gap at night without dosing. If taken like most other medications, on a more regular dosing interval, tachyphylaxis develops, which essentially means the efficacy of the medication reduces. ...Read more
See below: Sinemet® (carbidopa-levodopa) is a combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome.Sinemet® cr (carbidopa-levodopa) is a sustained-release combination of Carbidopa and Levodopa for the treatment of parkinson's disease and syndrome. ...Read moreSee 1 more doctor answer
On sinemet 2 times per day 62.5. I want off this to try other alternatives first how do I safely do this. I do not agree
with my diagnosis of pd.?
See your doctor: If you can't find any common ground then it's best to part ways and find a physician you feel mors comfortable with. That said, you should negotiate a time period during which you can try alternatives before resuming orthodox therapy. Your doctor will help wean you. ...Read moreSee 1 more doctor answer
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