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Doctor insights on: Sinemet Dopamine Affecting Agent

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What antidepressant medications selectively block neurotransmitters?

What antidepressant medications selectively block neurotransmitters?

Most newer ones: Most of the newer antidepressant medications affect specific neurotransmitters. Each does it slightly differently, accounting for the different response rates amongst them. The SSRI's primarily increase serotonin, the SNRI's both serotonin and norepinephrine, and buproprion mostly norepinephrine alone, and Brintellix affects many of them in different ways and in different places in the brain. ...Read more

Dr. John Landi
46 doctors shared insights

Sinemet (Definition)

Sinemet is a dopamine affecting agent which is a kind of anti-Parkinson's drug ...Read more


Dr. Alan Ali Dr. Ali
6 doctors agreed:
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Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Dr. Alan Ali Dr. Ali
6 doctors agreed:
Is zoloft's dopaminergic effect dose dependant like effexor's noradrenalinergic effect?

Zoloft (sertraline): Yes it is. Dopamin reuptake inhibition increases as dose increase. ...Read more

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Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

Does dopamite(dopamine supplement) increase more dopamine level or prescribed medicine like biperiden(dopamine reuptake inhibitor) does?

I'm curious: Why do you believe you need to take medication that claims to affect dopamine, especially OTC remedy which will NOT cross the brain-blood barrier? If you are depressed, you could see a psychiatrist, and if you have Parkinson's disease, a neurologist. ...Read more

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Which is more potent sinemet (carbidopa and levodopa) or the generic of carbidopa/levodopa?

Neither: Generic drugs are held to standards where the manufacturer must prove "bioequivalence" to the branded drug. The molecules must be structurally the same, and the same standard of quality and purity must be met. The pills and the packaging themselves may look different, but the active ingredient is the same. It can be thought of as the difference between clorox bleach and safeway brand bleach. ...Read more

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Is risperdal dopamine agonist?

No: How Risperdal (also called risperidone) works isn't entirely clear. It does act on Dopamine receptors, but it's an antagonist. It's also a serotonin receptor antagonist. ...Read more

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Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Is the selective norepinephine reuptake inhibitor, reboxetine, effective ?

Evidence says not: One meta-analysis* (a study pooling results from multiple other studies) suggested that reboxetine is ineffective & may be harmful. *(eyding d et.Al. "reboxetine for acute treatment of major depression: systematic review &meta-analysis of published &unpublished placebo &selective serotonin reuptake inhibitor controlled trials."bmj. 2010; 341:c4737). ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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Is Depakote a dopamine antagonist?

Is Depakote a dopamine antagonist?

No: According to our current understanding, Depakote work by altering calcium current, sodium channel, and the synthesis and breakdown of gaba, the main inhibitory neurotransmitter in the brain. ...Read more

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Is dopaminergic pathway involved in drug addiction?

Is dopaminergic pathway involved in drug addiction?

Yes: All drugs of abuse activate the Dopamine system in the reward pathway. ...Read more

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Does triavil block dopamine receptors in the central nervous system?

Does triavil block dopamine receptors in the central nervous system?

Yes: Triavil is an old medicine that is not often used anymore. It's a combination of Amitriptyline and perphenazine. The latter is a neuroleptic (antipsychotic) medication that mainly acts by blocking Dopamine receptors in the brain. ...Read more

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How effective is this medicine for treating Parkinson's disease: sinemet (carbidopa and levodopa) (carbidopa-levodopa)?

Probably the best: This medication has never been supplanted, and is still the standard to treat the Parkinsonian issue with dopamine depletion. ...Read more

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Do only dopaminergic neurons release dopamine?

Do only dopaminergic neurons release dopamine?

Yes: Yes, only dopaminergic neurons release dopamine, but there are several dopaminergic pathways in the brain. Dopaminergic neurons in midbrain are the main source of Dopamine in the mammalian cns. Losing these is associated with parkinson's disease. Dopamine neurons are involved with voluntary movement and other behavioral processes such as mood, reward, addiction, psychosis, and stress. ...Read more

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Can periactin (cyproheptadine hydrochloride) (cyproheptadine) be useful in relieving serotonin induced migraine caused by an ssri? Periactin (cyproheptadine hydrochloride) has antiserotonin affinity. Head hurts..

Might be useful: Although Cyproheptadine is nominally an anti-histamine, it does have seratonin antagonistic effects, and, has been best used as a migraine preventative in years past. Since it is cheap, could try it, but likely should start low dose and aim for about 4mg every 6 hrs. May take about two weeks to decide success at the higher dose. ...Read more

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Only noradrenergic antidepressant works for me, does inderal (propranolol) acts negative on noradrenergic effects of antidepressant ?At vasomotor centers.Regards.

Only noradrenergic antidepressant works for me, does inderal (propranolol) acts negative on noradrenergic effects of antidepressant ?At vasomotor centers.Regards.

Venlafaxine: It's not the vasomotor centers that are important in antidepressant response; it's the neuron synapses in the brain. Effexor (venlafaxine) inhibits reuptake of both serotonin and ne. Inderal can suppress some of the physical symptoms of anxiety (rapid heart rate, sweaty palms, tremulousness, etc). Some on chronic (not intermittent or "prn") Inderal have had more depression. Not everyone. You should be okay. ...Read more

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What meds, other than wellbutrin, (bupropion) can increase the dopamine re~uptake inhibitors?

What meds, other than wellbutrin, (bupropion) can increase the dopamine re~uptake inhibitors?

Several: Levodopa, which is used to treat parkinson's, encourages the brain to make dopamine. Tyrosine, an Amino Acid made from phenylalanine, is converted into levodopa, which is in turn converted to dopamine. Wellbutrin (bupropion) & the maoi's can also increase dopamine. Most tca's have minimal affinity for dat and thus don't increase Dopamine levels. Periwinkle and st. John's wort may also increase dopamine. ...Read more

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Is selegiline effective as azilect (rasagiline) for parkinsons?

Is selegiline effective as azilect (rasagiline) for parkinsons?

MAO-B inhibitors: Both selegiline (eldepryl) and Rasagiline (azilect) are mao-b inhibitors, with a couple important differences. Azilect (rasagiline) is much more specific for mao-b, meaning no risk of serotonergic crisis when used alongside ssri antidepressants (celexa, lexapro, etc). Azilect (rasagiline) is also the only neuroprotective drug for parkinson's. Take care! ...Read more

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Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?

Sine seratonin depletes other nerotransmitters like dopamine, norepinephrine, and epinephrine...By "deplete" does it mean a permanent thing?

Not correct: Serotonin does not deplete other neurotransmitters, but there is a balance especially between Dopamine and serotonin. This balance is dynamic and constantly re-establishing itself. Unless there is damage to neurons (which there can be when abusing certain drugs) neurotransmitter changes would not be permanent. ...Read more

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Can rhodiola interact with sinemet (carbidopa and levodopa)?

Probably not bad: I had to look up rhodiola as that was one i had never heard of. There are no reasons, at least theoretically, that the two should be a problem. I did a literature search and there are no articles in the medical literature looking at rhodiola and sinemet (carbidopa and levodopa). There are some laboratory papers that suggest rhodiola should be helpful in pd, but i could not find any clinical studies in people. ...Read more

Dr. James Lin
4 doctors shared insights

Dopamine Affecting Drug (Definition)

Dopamine affecting agents are a kind of anti-Parkinson's drug ...Read more


Dr. Martin Johnson
907 doctors shared insights

Dopamine (Definition)

Dopamine is an inotrope which is a kind of heart ...Read more