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Doctor insights on: Sikle Cell

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What chromosome carries the gene for sickle cell anemia?

What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

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Could a the sickle cell trait skip generations?

Could a the sickle cell trait skip generations?

No: Sickle cell trait is when a person has one mutated copy of the beta-hemoglobin gene and one normal copy. You always inherit the mutated hemoglobin from one of your parents. Thus, one parent always has at least sickle cell trait if the child has sickle cell trait. Therefore trait does not skip a generation. ...Read more

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Help docs, is hemoglobin AC a sickle cell trait?

No: Hgb AC is a heterozygous genetic state that is not sickle cell trait ( Hgb AS). Patient's with Hgb AC are clinically well with at worst mild asymptomatic anemia (most are not anemic). Individuals with Hgb AC can have children with Hgb SC (a type of severe sickle cell hemoglobinopathy) if their partner has either sickle cell trait (25% chance) or sickle cell disease (50% chance) ...Read more

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What chromosome is mutated in sickle cell disease?

What chromosome is mutated in sickle cell disease?

11: The beta globin gene is mutated in sickle cell anemia; it is located on chromosome 11. ...Read more

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Sickle cell disease - is it curable with a bone marrow transplant?

Sickle cell disease - is it curable with a bone marrow transplant?

I do not know.: Most patients with sickle cell diseaes have a very benign manifestation of the diseas (trait) and they can live close to a normal life. E few percentage of this people has severe disease. I do not have experience with bone marrow transplant for sickle cell disease. ...Read more

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What is the difference between sickle cell trait & sickle cell disease?

What is the difference between sickle cell trait & sickle cell disease?

Carrier vs. Affected: Sickle cell trait denotes being a carrier while sickle cell disease is someone who has the disorder. Sickling requires 2 genes. A person with the s gene and a normal gene would be a carrier and considered to have sickle cell trait. Someone who has s and s would be considered to have sickle cell disease and would likley be affected. ...Read more

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160 days Post auto stem cell transplant for NHL double hit cell counts low hemoglobin 9.6 platelets 63 white cells 1.7. Can this resolve on its own in time? How long? Fearing MDS.

160 days Post auto stem cell transplant for NHL double hit cell counts low hemoglobin 9.6  platelets 63   white cells 1.7.  Can this resolve on its own in time?  How long?  Fearing MDS.

Several possibilitie: There are several possibilities, but this may simply be a slow recovery after engraftment, especially if the trend is one of gradual improvement. You should be checked for vitamin B12 and folate (folic acid) deficiency. If the low counts are progressing, then discuss with your transplant physician a bone marrow with cytogenetics to rule out MDS, although MDS usually occurs at a longer interval after SCT. ...Read more

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Please help? Is the sickle cell trait deadly?

No: The vast majority of patients with sickle cell trait have no health consequences whatsoever. ...Read more

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Which is worse, b cell lymphoma or t cell lymphoma?

Which is worse, b cell lymphoma or t cell lymphoma?

T-cell NHL: The prognosis for t-cell non-hodgkin's lymphoma (nhl) vs. B-cell nhl depends on multiple factors, but in general t-cell nhl has a worse prognosis. One reason is that b-cell, cd20+ nhl can be treated with the anti-cd20 monoclonal antibody Rituximab in addition to chemotherapy. We currently don't have such an effective, low toxicity antibody (biologic treatment) for t-cell nhl. ...Read more

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With germ cell tumor that to deal with germ cell tumor cancer?

With germ cell tumor that to deal with germ cell tumor cancer?

Clarify, can be CA.: These can be cancer. These are tumors of germ cells which can be from the gonads, or ovary and testis, or from outside these areas and occur during embryonic development. These can be cancerous or non-cancerous. Prognosis varies. Some, like seminoma, have a very good prognosis. ...Read more

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If I have sickle cell trait is it possible to now be sickle cell anemia?

If I have sickle cell trait is it possible to now be sickle cell anemia?

Confusing question: SS disease requires the genes for sickle cell from both parents, while S trait has it from one. You cannot change the genetic makeup that you were born with. Someone with trait can have a kid with SS if the partner has trait or SS. ...Read more

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What is a merkel cell or a merkel cell cancer?

Rare skin cancer: Merkel cell is a rare skin cancer which must be treated surgically. It is derived from neuron doctrine cells and is rare compared to melanoma, basal or squamous cell carcinoma. It can occur on the face or extremities mad removal may recur lymph node dissection. It can spread to lymph nodes and radiation may be used after surgery to increase cure. ...Read more

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Asian strain of sickle cell anemia, what to do?

Asian strain of sickle cell anemia, what to do?

Asian strain?: I am not sure what you mean by "asian strain" of sickle cell anemia. One possibility could mean a person carries one copy of sickle hemoglobin, and the other copy is a different mutation that has a higher prevalence in asians (hb e or c or d). Whatever you are referring to, it is essential you have a good hematologist to advise you. Ask your question with more specifics if you know them. ...Read more

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My father has a rare type of sickle cell that affects his WBC's instead of RBC's. Is there any information on this type of Sickle Cell Trait?

Get better info: Your dad may have a white cell disorder but it has nothing to do with sickle cell trait which is a specific red cell disorder. You need to consult with your day and find out the proper name for his disorder before we can comment. A doc may have compared it to sickle cell trait to try to explain it. ...Read more

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Will a blood transfusion cause the sickle cell trait?

Will a blood transfusion cause the sickle cell trait?

No. : Blood transfusions will not cause sickle trait. Sickle trait is an inherited disease. You will get it from one of your parents. ...Read more

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What is large cell t cell lymphoma exactly?

What is large cell t cell lymphoma exactly?

Cancer of T-cells: T-cell non-hodgkin's lymphoma is a cancer of the t type (subset) of lymphocytes. Other types of lymphocytes include b cells. Other lymphomas include over 40 subtypes including hodgkin's lymphoma. ...Read more

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