Doctor insights on:
Side Effects Of Bcg Treatment For Bladder Cancer
No: Bcg is a topical therapy that is essentially a type of immune based therapy applied only to bladder cells. Traditional chemotherapy is given intravenously and thus all body cells are exposed. Some chemotherapy drugs can be given topically like BCG and probably exert their effect via typical cancer cell-killing compared to immune stimulating effects of BCG similarly administered. ...Read more
Cancer is a group of diseases that is characterized by uncontrolled cell growth leading to invasion of surrounding tissues that spread to other parts of the body. Cancer can begin anywhere in the body and is usually related to one or more genetic mutations that allow normal cells to become malignant by interfering with internal cellular control mechanisms, such as programmed cell death or by preventing ...Read more
See below : Intravesical BCG used to both treat and prevent recurrence of urothelial bladder cancer. Despite its widespread common usage, its specific mechanism of action poorly understood. BCG is an attenuated form of the bacteria that causes TB (much like a vaccine) that "stimulates" (not weakens) ones immune system in such a way to kill the tumor cells. Pts with weak immune systems have poorer responses. ...Read more
I failed interferon treatment and BCG treatment for bladder cancer. Is surgery the only option left?
Probably best option: If you have failed tretament with BCG and interferon, some patients may reposnd to treatment with valstar (valrubicin). However, depending on the specifics of your bladder cancer, cystectomy and urinary diversion may be your best option. You should discuss this with your urologist. ...Read more
I was diagnosed with bladder cancer in 1980 and one treatment with BCG 1990, since then one tumor and haven't had tumor since 2000. Do i need a cysto ?
Maybe: I think you can avoid a cystoscopy if you do not have any symptoms and your urinalysis is normal. Also, I would base it on your original pathology. If it was a low grade tumor you can hold off. You could do a urine cytology, urine sample looking for abnormal cells, to insure there is no evidence of a more aggressive tumor. ...Read more
Immune system based: Bcg is a weakened bacteria in the family of germs that causes tuberculosis. In bladder cancer, it is believed that interactions of BCG and molecules in the cellular structure of the bladder itself induces an immune-mediated response which can cause superficial cancers of the bladder to regress and can delay or prevent recurrence in many cases. It is usually given weekly for 6 weeks to start. ...Read more
BCG plus interferon : There is evidence that BCG plus ifn can salvage or successfully treat people who have failed BCG alone. Also, your overall risk depends on the grade and stage of your original cancer. If it is low grade low stage, then the overall risk is quite different than patient with high grade superficial bladder cancer. ...Read more
For a 70-year-old man who was recently diagnosed with bladder cancer, is BCG a reasonable 1st treatment?
Maybe: Bcg is a first good step but depends on the biopsy specimen. Bcg is standard treatment for certain types of bladder cancer and if the patient meets those criteria, then it is a good first step. It is not necessarily dependent on age. ...Read more
Not really: Neither one has any benefit but they also do no harm. ...Read more
Yes.: Ask your doctor, of course, since your particular circumstance may differ...but intravesicular (in the bladder) BCG treatment for superficial bladder cancer does not make shingles vaccine dangerous or ineffective. Your age and medical history put you at enough risk of shingles that a vaccination is beneficial. ...Read more
My mom 68 is diagnosed with bladder cancer t1 grade 2-3. They’re suggesting a second TURBT 3 weeks after the first and BCG treatment will start later.how serious is her case? Will she be ok ?
Not very serious:
This is early stage of bladder Cancer which is superficial(not going into the muscle layer).
After the bulk of the tumor is removed with TURBT, BCG treatments are instilled into the bladder cavity once week. This is a form of immunotherapy which can control early bladder cancer in most cases. She will need periodic monitoring to follow the tumor and see how she is doing over the next several years ...Read more
Will treatment with BCG for bladder cancer cause possible complications to a recent aortic tissue valve replacement?
Not likely: This is a reasonable concern, but this would be an unusual complication. A 2010 study in journal of urology found that this complication is no more likely in patients with valves and other prostheses than in the general population, and that having a valve should not prevent you from receiving this treatment. ...Read more
I have had 4 turb's for non invasive bladder cancer and have decided not to have BCG treatments. Can I just have my bladder removed?
Not standard: Local bladder therapy such as BCG and others can put off the need for bladder removal for quite a period. Bladder removal can be done but urine pathway reconstruction will need to be surgically done too. Your urologist can discuss other local treatment drugs besides bcg. Finally, many centers are looking at robotic bladder surgery. ...Read more
I'm about to have my 6th of 6 mitomycin treatment for bladder cancer. Taking vesicare (solifenacin). Feeling very fatigued with horse throat; is that side effects?
Bladder Cancer: This depends on the extent of surgery/treatment and whether part of the bladder is resected, the whole bladder - requiring a urinary division procedure - or localized intra vesicular procedures. In some cases, an adjuvant drug, such as bcg, is used inside the bladder. The best resource I use is http://www.Cancer.Gov/cancertopics/pdq/treatment/bladder/patient/page1. ...Read more
Surgery: Depending on the stage and type of bladder cancer, treatment will vary. This includes observation, instilling medicines into the bladder (bcg), radical surgery, chemotherapy, and radiation therapy. The appropriate treatment will be dependent on the stage, type of cancer, and patient preference. ...Read more
Hello Dr Bennett, I have experienced hardening of the bladder wall after chemo and radio treatment for stage 4 bladder cancer, will this condition go?
Will remain: Best results are for lesions of the mucosa. Once bladder wall invaded, especially with extension beyond the bladder then depending on overall situation, radical cystectomy with neobladder utilized. If lesion too advanced primary lesion therapy may be relegated to local RT chemo for control of symptoms. ...Read more
How often does bladder cancer come back? After successful bladder cancer treatment, is it common for it to come back? Can it grow back as a metastatic cancer even after having your whole bladder removed?
Stage dependent: It depends on the stage and type of bladder cancer when it was diagnosed as well as whether or not all recommended treatments wee taken. It can metastasize and that is why some patients need chemotherapy whennsafenafter surgery. It takes only remnant microscopic cells to have leaked out before surgery for it to get into the blood stream or outside the bladder. Stats are stage and path dependent. ...Read more
Best guess what would is the prognosis of an 87 y/o w/ metastatic bladder cancer that spread to the lung without treatment and is otherwise healthy?
Bloody urine with some clots, painful urination. All went away after treatment on bactrim (sulfamethoxazole and trimethoprim). Lab report not in. Is this likely UTI or bladder cancer?
I had BCG chemo for bladder cancer & developed serious infection requiring hospitalization. What other chemo drug can be used?
It depends: Bcg sepsis is a known, yet uncommon complication of BCG treatment for bladder cancer. The next option really depends on your specific bladder cancer - your urologist will be bettre ablet o discuss this with you. The next option may be for intravesical mitomycing, intravesical valrubicin, or possibly cystectomy. ...Read more
Bladder cancer path showed stage 1 noninvasive. Instead of next step being chemo or BCG Dr is doing another biopsy to "re-look". Opinions please?
Rebiopsy possible: Pre invasive bladder Ca means lesion is confined to lining and has not invaded muscle. No problem in rebiopsy but after that even if neg. there is usually a field effect in which benign appearing cells adjacent to a tumor are p remalignant. On that basis it would be better to have BCG treatment after the second look and then follow carefully ...Read more
Inc in creatinine (2.0 vs 1.6) post hosp for kidney reaction (creat 5, then ret to normal) to BCG for 0-stage bladder cancer. 79 yo cauc m good health?
No: Bcg is not a vaccine that prevents bladder cancer. It is used as a treatment for certain types of superficial bladder cancer by being placed directly into the bladder. It is believed to stimulate an immune response against the tumor itself. ...Read more
The bladder is a muscular organ in the pelvis that accepts urine from the kidneys, stores the urine at low pressure, & expels the urine during voluntary voiding. Though seemingly a simple reservoir, the bladder is a complex organ intricately connected with the brain and spinal cord with sensory, motor, and autonomic circuits. The muscular layer that contracts during voids ...Read more