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Side Effects Of Adriamycin And Cytoxan
Can you tell me about the long term side effects from the chemotherapy drugs adriamycin (doxorubicin) and cytoxin?
TWO MAJOR ONES: Adriamycin (doxorubicin) and Cytoxan is a great combination regimen used in breast cancer. The major long term side effects for both of these drugs is secondary leukemias, risk is around 1%. For adriamycin (doxorubicin) there is a concern for cardiotoxicity, but risk rises with cumulative dose. Risk is less than 10%. Patients get an echocardiogram or muga scan prior to therapy to evaluate heart status. Talk to your md. ...Read moreSee 1 more doctor answer
Had an ultrasound that showed the liver to be slightly heterogeneous. Can that be due to past chemo therapy with Adriamycin, (doxorubicin) Cytoxan and Taxol?
Hx ILC, tx high dose Adriamycin/Cytoxan 2006. Now, fatigue, difficult swallow, CT scan = one tonsil & lymph nodes in neck enlarged. Risk lymphoma?
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Adriamycin is a very effective drug and is widely used in oncology.
It does have some serious side effects but they can be manged quite well except for Hair loss. It can cause nausea and vomiting (but it can be easily controlled with anti-nausea medication. It can also affect the heart but your oncologist will take due precuations ...Read more
Reduction in WBC: Cytoxan (cyclophosphamide) can be used in two ways. When given in combination with other chemotherapeutic agents such as CMF it has strong tumoricdal effects on the treated lesion such as breast carcinoma. It essentially acts in a similar fashion on DNA the way nitrogen mustard effected tumors in the past. When used in low doses, it is effective in minimizing suppressor T cell activity. ...Read more
Nausea, vomiting: Cytoxan (cyclophosphamide) can be given orally or intravenously at various different dosage ranges. Nausea and vomiting are probaly the most common side-effects. Abdominal pain can occur sometimes when given orally. Hair loss, drop in blood counts, fatigue, loss of appetite, discoloration of the skin are not uncommon. High doses can irritate the urinary bladder and can cause blood in the urine. ...Read more
Reduce toxicity with: Fortunately I have not had to use it personally but some of my patients have. Doxorubicin can cause nausea, vomiting, low white blood cell count & hair loss, but the most serious side effect is serious heart failure.There is evidence that taking vit c, e, b2, coq10, carnitine and melatonin can protect against cardiotoxicity while enhancing effectiveness! I strongly advise taking these. See comment:. ...Read more
The drug is taxotere (docetaxel) and cyclophosphamide used in chemo due to early stage of invasive lobular carcinoma does side effect cause insomia, depression?
Chemo and cancer: Dealing with cancer and its treatment is not something easy to do in many cases. Not only it is affecting your physical condition, emotionally, you can also develop anxiety, depressed mood, depression etc through out the battle. The chemo themselves do not give you insomnia. However, steroids are given prior to chemo, and this can cause insomnia. Depression/anxiety cause insomnia too. ...Read more
While these agents: (alkylators) were the standfast drugs from the 1960's, their main role now is in very high doses prior to bone marrow or stem cell transplants. They reduce some cancers, particularly lymphoma and perhaps breast cancer, but the class is limited by marrow toxicity, resistance, and late effects. It can reduce some tumors, very few, but is usless in many. ...Read more
It depends: It's extremely helpful for some cases of lupus kidney disease, has little to offer for other presentations. The whole business of treating lupus is complicated enough that there's room for you to make an informed decision between possible Rx's. In my college days, lupus was often a death sentence; now it tends to be manageable but still difficult. Good luck. ...Read more
Adriamycin (doxorubicin): “Doxorubicin HCl is contraindicated in patients with: Severe myocardial insufficiency, Recent (occurring within the past 4–6 weeks) myocardial infarction, Severe persistent drug-induced myelosuppression, Severe hepatic impairment (defined as Child Pugh Class C or serum bilirubin level greater than 5 mg/dL) & Severe hypersensitivity reaction to Doxorubicin HCl including anaphylaxis/” See: ...Read more
It can: It can- but that will depend on the cumulative dose given, your age when receiving the treatment, whether you also received other kind of therapy? Radiation etc. Please discuss your situation with your oncologist. ...Read more
Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read moreSee 1 more doctor answer