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Doctor insights on: Side Effects Of Adriamycin And Cytoxan

TWO MAJOR ONES: Adriamycin (doxorubicin) and Cytoxan is a great combination regimen used in breast cancer. The major long term side effects for both of these drugs is secondary leukemias, risk is around 1%. For adriamycin (doxorubicin) there is a concern for cardiotoxicity, but risk rises with cumulative dose. Risk is less than 10%. Patients get an echocardiogram or muga scan prior to therapy to evaluate heart status. Talk to your md. ...Read more

Many: Side effects of this chemotherapy combination include fatigue, hair loss, nausea, vomiting, finger and toe nail changes, low blood counts. ...Read more

Yes: Yes many drugs can affect the liver. Chemotherapy medications can cause these changes to the liver. Discuss this with your oncologist ...Read more

Possible: Adriamycin/cytoxan therapy are risk factors for the development of future neoplasms, including lymphoma. See your PCP for further eval by an oncologist. ...Read more

Tell us more about y: Please give us some background about your question.
Adriamycin is a very effective drug and is widely used in oncology.
It does have some serious side effects but they can be manged quite well except for Hair loss. It can cause nausea and vomiting (but it can be easily controlled with anti-nausea medication. It can also affect the heart but your oncologist will take due precuations ...Read more

Possible AE's: May include infertility, heart dysfunction, bone marrow insuficiency, a second malignancy (leukemia) - which may develop years after treatment has ended. ...Read more

Reduction in WBC: Cytoxan (cyclophosphamide) can be used in two ways. When given in combination with other chemotherapeutic agents such as CMF it has strong tumoricdal effects on the treated lesion such as breast carcinoma. It essentially acts in a similar fashion on DNA the way nitrogen mustard effected tumors in the past. When used in low doses, it is effective in minimizing suppressor T cell activity. ...Read more

Cytoxan (cyclophosphamide): Open this link:

http://www. Nlm. Nih. Gov/medlineplus/druginfo/meds/a682080.Html

if any concern, see and discuss with your md in detail. ...Read more

Nausea, vomiting: Cytoxan (cyclophosphamide) can be given orally or intravenously at various different dosage ranges. Nausea and vomiting are probaly the most common side-effects. Abdominal pain can occur sometimes when given orally. Hair loss, drop in blood counts, fatigue, loss of appetite, discoloration of the skin are not uncommon. High doses can irritate the urinary bladder and can cause blood in the urine. ...Read more

Reduce toxicity with: Fortunately I have not had to use it personally but some of my patients have. Doxorubicin can cause nausea, vomiting, low white blood cell count & hair loss, but the most serious side effect is serious heart failure.There is evidence that taking vit c, e, b2, coq10, carnitine and melatonin can protect against cardiotoxicity while enhancing effectiveness! I strongly advise taking these. See comment:. ...Read more

Chemo and cancer: Dealing with cancer and its treatment is not something easy to do in many cases. Not only it is affecting your physical condition, emotionally, you can also develop anxiety, depressed mood, depression etc through out the battle. The chemo themselves do not give you insomnia. However, steroids are given prior to chemo, and this can cause insomnia. Depression/anxiety cause insomnia too. ...Read more

While these agents: (alkylators) were the standfast drugs from the 1960's, their main role now is in very high doses prior to bone marrow or stem cell transplants. They reduce some cancers, particularly lymphoma and perhaps breast cancer, but the class is limited by marrow toxicity, resistance, and late effects. It can reduce some tumors, very few, but is usless in many. ...Read more

Yes: Cytoxan (cyclophosphamide) is used to treat some of the manifestations of lupus. Most commonly this can be involvement of organs such as the brain, kidneys etc. ...Read more

It depends: It's extremely helpful for some cases of lupus kidney disease, has little to offer for other presentations. The whole business of treating lupus is complicated enough that there's room for you to make an informed decision between possible Rx's. In my college days, lupus was often a death sentence; now it tends to be manageable but still difficult. Good luck. ...Read more

Adriamycin (doxorubicin): “Doxorubicin HCl is contraindicated in patients with: Severe myocardial insufficiency, Recent (occurring within the past 4–6 weeks) myocardial infarction, Severe persistent drug-induced myelosuppression, Severe hepatic impairment (defined as Child Pugh Class C or serum bilirubin level greater than 5 mg/dL) & Severe hypersensitivity reaction to Doxorubicin HCl including anaphylaxis/” See: ...Read more

Adriamycin (doxorubicin): Doxorubicin is brand name of the generic Adriamycin (doxorubicin). ...Read more

Yes and no: Depends on the dose. At higher doses, yes. ...Read more

It can: It can- but that will depend on the cumulative dose given, your age when receiving the treatment, whether you also received other kind of therapy? Radiation etc. Please discuss your situation with your oncologist. ...Read more

Adriamycin (doxorubicin): Adriamycin (doxorubicin) is beneficial in the treatments of a number of types of cancer including leukemia. ...Read more

Not a standard treat: Cytoxan (cyclophosphamide) and 5-fu jused to be used as first line chemo for breast cancer, but there are much more effacious drugs available now. I would not use these drugs now as first line treatment fofr anything except in special circumstances. ...Read more

Lupus cytoxan: Finished cytoxan Rx and WBC low? Asks what could be causing this? ANS: cytoxan or lupus. Ask your team as they know you best. ...Read more

Adriamycin (doxorubicin): Yes, Adriamycin (doxorubicin) requires a prescription.

Cyclophosphamide: "“Cyclophosphamide is contraindicated in patients who have a history of severe hypersensitivity reactions to it, any of its metabolites, or to other components of the product. Possible cross-sensitivity with other alkylating agents can occur. Cyclophosphamide is contraindicated in patients with urinary outflow obstruction.” See: http://dailymed. Nlm. Nih. Gov/dailymed/drugInfo. Cfm? Setid=591d9955-3d9 ...Read more

Cytoxan (cyclophosphamide): Cytoxan (cyclophosphamide) is one type of drug that has been used widely to treat different problems such as - rheumatological problem, blood disorder and different kind of cancer- blood and solid cancer. Yes, it is an effective treatment -if it is used in appropriate setting. For furthe info regarding Cytoxan (cyclophosphamide) - open this link: http://www. Nlm. Nih. Gov/medlineplus/druginfo/meds/a682080.Html. ...Read more

Yes.: Generic name of Cytoxan is cyclophosphamide. It is a drug commonly used to treat a variety of cancers, but may also be used to treat some autoimmune disorders, such as lupus. ...Read more

Yes: Used in breast cancer, lymphomas, sometimes myeloma, occasionally ovarian cancer. Probably one of the most common chemotherapy drugs used. ...Read more

Good, but....: PredForte is considered first line. Serious uveitis is best treated the Himira or Enbrel (etanercept) like TNF-alpha inhibitors. Cyclophosphamide works as do other immunosuppressants! Keep in mind that chronic, recurrent uveitis can lead to glaucoma and is associated with a number of rheumatic diseases: sarcoidosis, spondylitis, Reiter's, psoriatic arthritis, etc! ...Read more

Cyclophosphamide: Cyclophosphamide is beneficial in the treatment of leukemia. ...Read more

Dry skin and Chemo: Chemotherapy destroys The Bad and the Good cells in the skin. It also depletes the ability of your follicles to produce sebum (natural moisturizer). you can try Lac-Hydrin lotion over the counter for skin rehydration. ...Read more

Cyclophosphamide: Cyclophosphamide is FDA Pregnancy Category D (Positive evidence of risk). ...Read more