Doctor insights on:
Sickle Cell What Is It
A constitutional Dz: Ssdz is a constitutional malady that affects all organ systems. The underlying pathology is micro vascular occlusion that compromises the tissue downstream. We worry about multiple sequelae of this disease. Pain crises are most common. More ominous are the acute chest syndrome and stroke, both of which can be life threatening. Pts with sickle disorders need care in comprehensive centers by experts. ...Read more
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
Penicillin: Children less than 5 years of age should receive penicillin prophylaxis every day. They should receive their immunizations as scheduled, including annual influenza vaccines, Pneumovax 23 and Menactra vaccines at 2 years of age. The grand child should see a pediatric hematologist every 6 months. Lastly, fever of 101 degrees or higher is a medical emergency- see md immediately. ...Read moreSee 1 more doctor answer
Disease or Trait?: Do you have sickle cell disease or trait (carrier)? Sickle cell disease is inherited in an autosomal recessive pattern. If both parents have sickle cell disease, then the child will have the disease. If both parents have sickle cell trait, then there is a 25% chance of having a child with sickle cell disease and 50% chance of having a child with sickle cell trait (carrier). ...Read moreSee 1 more doctor answer
A healthy child: Expect a healthy child! if you have sickle cell anemia then you will pass that trait on to all your children and they will lead normal lives with just sickle cell trait. It is important to know if the father of the child has sickle trait...If so then there is a 50 % chance your children together will have sickle cell anemia. Have you discussed this with your physician? You need to. ...Read more
May help: Usually spleens autoinfarct (shrink to small fibrous tissue), sometimes spleens capture red cells and get very large with a lot of blood in them. This is called splenic sequestration syndrome and sometimes splenectomy is required. Infection is the major complication and can be prevented with vaccinations and oral antibiotics. Please speak to your child's doctor. ...Read more
Check with Heme Dr.: Hematology doctors who takes care of the sickle problems have guidelines on cold medications that are ok to use. Some doctors recommend not using tylenol/motrin/advil to treat fever, because such meds may "mask" a fever that would otherwise send a patient to the doctor to get treatment for an infection. Some recommend avoiding meds that can increase heart rate (such as phenylephrine and sudafed). ...Read more
Both carriers of sickle cell anemia. What can you tell them about their chances of any child of theirs exhibiting this disease?
My husband and I are both carriers of sickle cell anemia. What are our chances of our children exhibiting this disease?
25%: If both of you have sickle cell trait then each of you has one normal beta hemoglobin gene (a) and one with the sickle cell mutation (s). Your children will inherit one beta globin gene from each of you for a total of two. Therefore for each child that you have, there is a 25% chance of sickle cell disease (ss), a 50% chance sickle cell trait (as), and 25% chance of normal hemoglobin (aa). ...Read moreSee 1 more doctor answer
Please see doctor: Infants with sickle cell disease (or anemia--same), should be followed by a pediatric hematologist. The infants usually do very well on antibiotic prophylaxis and folic acid. Sickle cell disease is caused by the s hemoglobin gene given to the new baby by each parent. One gene would produce the sickle trait from one parent. Fever with the disease is an emergency and must be seen immediately. ...Read moreSee 1 more doctor answer
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