Doctor insights on:
Sickle Cell Thalassemia
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read moreSee 1 more doctor answer
I have a hemoglobinopathy (not sickle cell or thalassemia). At what point is medication considered for my anemia?
Symptoms or severe: Depends on specific etiology, as treatments may vary significantly. Generally aggressive tx like transfusions are avoided except in emergencies, but other tx will be considered if there are sxs (like dizziness, weakness, shortness of breath) or if the blood level is low enough to cause other issues (e.g., high-output heart failure). Diet may be important as well in minimizing or avoiding meds. ...Read moreSee 2 more doctor answers
Im 33 with sickle cell beta+thalassemia Im having sharp pain in right ear n jaw n throat. My neck hurtscslso all on my right side. Whats wrong?tp
More information?: For short duration pain, Sickle crisis may be but this pain sounds like many other problems. While deep pain may be difficult to pinpoint for the patient, she can have all of the diseases other people have. TMJ arthritis, supperative otitis media, lesions of middle ear, TM, upper pharynx. Many people with Sickle beta plus thal do not know it and never have seizures , others have them more often ...Read moreSee 2 more doctor answers
Yes: The mutations causing sickle cell disease and beta thalassemias both occur in the beta hemoglobin gene. There are many people who have one copy of beta hemoglobin with the sickle cell mutation, and the other copy carries a beta-thalassemia mutation. Depending on the combination, symptoms can vary. For a nice summary, see: http://www.Cdc.Gov/ncbddd/sicklecell/facts.Html. ...Read moreSee 1 more doctor answer
Yes!: Sickle cell and beta thalassemia both affect the same part of hemoglobin. If you inherit a sickle gene from one parent and a thalassemia gene from the other, you have sickle/b-thalassemia. The severity depends on whether the thal gene works a little (b+) or not at all (b0). Sickle cell and Alpha thalassemia are inherited independently; you can inherit both from the same parent or one from each. ...Read more
Yes: Both sickle cell and beta thalassemia affect the same gene; each person has 2 copies of that gene. If you have a sickle mutation on one gene and a thal mutation on the other you have sickle/beta-thal, which behaves much like sickle cell anemia. You can also inherit sickle cell anemia and Alpha thalassemia together. ...Read moreSee 1 more doctor answer
Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. Two hgbs alleles causes sickle cell dz. But you can inherit one hgbs and one beta thal allele (so called sickle-beta thal). Dz severity depends on beta globin expression from thal allele. ...Read more
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