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Doctor insights on: Sickle Cell Animation

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Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more

Dr. James Ball
355 doctors shared insights

Sickle Cell Disease (Definition)

A group of disorders that cause red blood cells to become ...Read more


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What is the difference between sickle cell trait & sickle cell disease?

What is the difference between sickle cell trait & sickle cell disease?

Carrier vs. Affected: Sickle cell trait denotes being a carrier while sickle cell disease is someone who has the disorder. Sickling requires 2 genes. A person with the s gene and a normal gene would be a carrier and considered to have sickle cell trait. Someone who has s and s would be considered to have sickle cell disease and would likley be affected. ...Read more

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What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

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Is sickle cell anemia contagious?

Is sickle cell anemia contagious?

No: Sickle cell anemia is not an infection - thus it is not contagious. It is a genetic disease and so, it is hereditary. ...Read more

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What causes the sickle cell trait?

What causes the sickle cell trait?

It is inherited: Hemoglobin (HGB) is a complicated chemical that is in the red blood cells and carries oxygen. We inherit one gene from each parent that makes one of the parts of HGB called beta chains. If we inherit a sickle beta chain gene from one parent and a normal beta chain gene from the other, we have sickle trait. If we inherit a sickle beta chain gene from both parents, we have sickle cell anemia. ...Read more

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Are white blood cells affected by sickle cell trait?

Are white blood cells affected by sickle cell trait?

No, they are not.: In sickle cell trait, only the red blood cells carry an anormality. The white blood cells and platelets are not affected. ...Read more

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What chromosome carries the gene for sickle cell anemia?

What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

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Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Can sickle cell trait affect the white blood cells?

Can sickle cell trait affect the white blood cells?

No.: Sickle cell trait (one copy of beta-globin gene with sickle mutation and one normal copy) will not affect white blood cells. Those with sickle cell disease (two sickle genes) can have chronically elevated white blood cell counts, caused in part by inflammation in the blood vessels. ...Read more

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What is sickle cell trait and anemia?

What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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Please help? Is the sickle cell trait deadly?

Please help? Is the sickle cell trait deadly?

No: The vast majority of patients with sickle cell trait have no health consequences whatsoever. ...Read more

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Different between sickle cell anaemia and beta-thalassemia?

Different between sickle cell anaemia and beta-thalassemia?

Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. Two hgbs alleles causes sickle cell dz. But you can inherit one hgbs and one beta thal allele (so called sickle-beta thal). Dz severity depends on beta globin expression from thal allele. ...Read more

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Is sickle cell disease genetic?

Is sickle cell disease genetic?

Yes: The recessive sickle gene is carried silently in a percentage of the population.When two carriers produce offspring their is 25% risk with each conception that an affected baby will be born. ...Read more

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What chromosome is mutated in sickle cell disease?

What chromosome is mutated in sickle cell disease?

11: The beta globin gene is mutated in sickle cell anemia; it is located on chromosome 11. ...Read more

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Ivf ethical for people with sickle cell trait?

Yes: But you should also have your partner tested. If he also has the sickle cell trait, then you can actually have the option to do genetic testing to pick embryos that are not effected with sickle cell disease. ...Read more

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How does exchange transfusion benefit sickle cell patients?

How does exchange transfusion benefit sickle cell patients?

Removes sickle cells: Acute red cell exchange is useful in acute infarctive stroke, in acute chest and multi-organ failure syndromes. The process replaces sickled red blood cells with normal red blood cells. This procedure can also benefit certain patients on chronic transfusion plans by replacing sickled cells without increasing the viscosity of blood. ...Read more

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What make sickle cell patients lean?

What make sickle cell patients lean?

Not all patients....: With sickle cell disease are lean, but most are. There are several reasons, and many things we don't know. First, the half life of sickle red cells is much shorter than for normal rbcs. Thus pts must make red cells much more often, which requires energy. Also, caloric intake for sickle cell pts is less than required at quiescence and falls during crises and hospitalization. Many other factors 2. ...Read more

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Is malaria and sickle cell anemia related?

Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read more

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