Top
20
Doctor insights on: Sickle Cell Aniema

Share
1

1
Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

See 2 more doctor answers
Dr. James Ball
356 doctors shared insights

Sickle Cell Disease (Definition)

An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more


2

2
Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more

3

3
Is sickle cell anemia contagious?

Is sickle cell anemia contagious?

No: Sickle cell anemia is not an infection - thus it is not contagious. It is a genetic disease and so, it is hereditary. ...Read more

See 1 more doctor answer
4

4
What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

See 1 more doctor answer
6

6
Is sickle cell disease genetic?

Is sickle cell disease genetic?

Yes: The recessive sickle gene is carried silently in a percentage of the population.When two carriers produce offspring their is 25% risk with each conception that an affected baby will be born. ...Read more

7

7
Different between sickle cell anaemia and beta-thalassemia?

Different between sickle cell anaemia and beta-thalassemia?

Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. Two hgbs alleles causes sickle cell dz. But you can inherit one hgbs and one beta thal allele (so called sickle-beta thal). Dz severity depends on beta globin expression from thal allele. ...Read more

8

8
What is sickle cell anemia?

What is sickle cell anemia?

Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capillaries. Blocked circulation causes extreme pain in joints, abdomen, or chest. ...Read more

See 1 more doctor answer
9

9
What is the difference between sickle cell trait & sickle cell disease?

What is the difference between sickle cell trait & sickle cell disease?

Carrier vs. Affected: Sickle cell trait denotes being a carrier while sickle cell disease is someone who has the disorder. Sickling requires 2 genes. A person with the s gene and a normal gene would be a carrier and considered to have sickle cell trait. Someone who has s and s would be considered to have sickle cell disease and would likley be affected. ...Read more

10

10
What is sickle cell trait and anemia?

What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

12

12
Can people with sickle cell anemia donate blood?

Can people with sickle cell anemia donate blood?

No: A diagnosis of sickle cell disease precludes donation of blood. This is not only because of the presence of the disease itself, but also because patients with sickle cell disease fail to meet the hemoglobin criteria for donors set by the red cross, which is 12.5g/dl. ...Read more

14

14
What is sickle cell disease?

Abnormal blood cells: Sickle cell disease occurs when there is an abnormal type of hemoglobin in blood cells. Thought to be a survivor advantage against malaria, when these cells have too little oxygen they collapse and get stuck in small vessels. This cuts off the blood supply to organs and causes severe pain. Sickle cell traits is when only half the genes code for the abnormal hemoglobin, usually not symptomatic. ...Read more

See 1 more doctor answer
15

15
What is sickle cell disease?

Red blood disorder: Autosomal recessive disorder when rbc's become rigid and cannot carry oxygen. The hemoglobin is abnormal. Also know as hbss vs hbas or trait. With low oxygen tension the beta chain of the hemoglobin molecule cannot carry oxygen properly and takes a different form-becomes sickle shaped, inelastic. They cannot pass through capillaries and lead to occlusion and ischemia. Rx transfusions, fluids. ...Read more

See 1 more doctor answer
Dr. Jay Park Dr. Park
2 doctors agreed:
16

16
What chromosome carries the gene for sickle cell anemia?

Dr. Jay Park Dr. Park
2 doctors agreed:
What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

See 1 more doctor answer
18

18
What chromosome is mutated in sickle cell disease?

What chromosome is mutated in sickle cell disease?

11: The beta globin gene is mutated in sickle cell anemia; it is located on chromosome 11. ...Read more

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
20

20
Is sickle cell anemia painful?

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more