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Doctor insights on: Sickle Cell Anemia Pamphlet

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Is malaria and sickle cell anemia related?

Is malaria and sickle cell anemia related?

Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read more

Dr. James Ball
365 doctors shared insights

Sickle Cell Disease (Definition)

An inherited blood disease causing red blood cells to be sickle (curved) shaped instead of round. It shortens life expectancy, and can result in bacterial infections, painful swelling of the hands and feet, fever, arthritis, leg ulcers, fatigue, anemia, eye damage, and ...Read more


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Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Can people with sickle cell anemia donate blood?

Can people with sickle cell anemia donate blood?

No: A diagnosis of sickle cell disease precludes donation of blood. This is not only because of the presence of the disease itself, but also because patients with sickle cell disease fail to meet the hemoglobin criteria for donors set by the red cross, which is 12.5g/dl. ...Read more

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Is sickle cell anemia contagious?

Is sickle cell anemia contagious?

No: Sickle cell anemia is not an infection - thus it is not contagious. It is a genetic disease and so, it is hereditary. ...Read more

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Is sickle cell crisis more severe in sickle cell thalassemia or sickle cell alone?

Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more

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Can we use hydroxyurea with sickle cell anemia patient?

Can we use hydroxyurea with sickle cell anemia patient?

Sickle cell: Hydrea (hydroxyurea) is approved in patients with sickle cell anemia and prevents sickling of these cells and avoids sickle crisis. Risks versus benefits have to be weighed in by a hematologist before prescribing it. ...Read more

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What is sickle cell anemia?

What is sickle cell anemia?

Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capillaries. Blocked circulation causes extreme pain in joints, abdomen, or chest. ...Read more

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What is sickle cell trait and anemia?

Genes: Sickle cell anemia occurs when someone has 2 sickle cell genes. Normal hemoglobin (hb) genes code for hb a. A sickle cell gene codes for hb s. Having 1 hb a gene & 1 hb s gene leads to sickle trait. This will have no symptoms, but has some health consequences. 2 genes for hb s leads to sickle cell anemia. To make things more complicated, there are other abnormal hb genes that can cause problems. ...Read more

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Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Do beta thalassemia and sickle cell anemia always reduce life expectancy?

Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more

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Dr. Jay Park Dr. Park
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Can sickle cell anemia be fatal?

Dr. Jay Park Dr. Park
5 doctors agreed:
Can sickle cell anemia be fatal?

Yes: Individuals with sickle cell anemia are at high risk to develop invasive bacterial infections, e.g., meningitis and bacteremia, especially by pneumococcus. Penicillin prophylaxis, immunization, and prompt medical attention for febrile illness have greatly reduced fatality from serious infection. ...Read more

Dr. Jay Park Dr. Park
2 doctors agreed:
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What chromosome carries the gene for sickle cell anemia?

Dr. Jay Park Dr. Park
2 doctors agreed:
What chromosome carries the gene for sickle cell anemia?

Chromosome No. 11: Point mutation at beta-globin gene located at chromosome no. 11 results in production of defective hemoglobin, sickle hemoglobin. ...Read more

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Different between sickle cell anaemia and beta-thalassemia?

Different between sickle cell anaemia and beta-thalassemia?

Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. Two hgbs alleles causes sickle cell dz. But you can inherit one hgbs and one beta thal allele (so called sickle-beta thal). Dz severity depends on beta globin expression from thal allele. ...Read more

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Describe symptoms of sickle cell anemia trait?

Usually none.: Patients with sca trait usually have no symptoms. If they are in an environment where oxygen is low, like high altitude, it is possible to have a pain crisis like sca patients get, but it is quite rare. ...Read more

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
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Is sickle cell anemia painful?

Dr. Liawaty Ho Dr. Ho
5 doctors agreed:
Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

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What is sickle cell beta thalassemia?

What is sickle cell beta thalassemia?

Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more

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How dangerous is sickle cell anemia?

More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more

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What is sickle cell anemia?

Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capillaries. Blocked circulation causes extreme pain in joints, abdomen, or chest. ...Read more

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What is the trend in sickle cell anemia?

Who will have it bad: The trend currently is trying to find out why some people have very little problems and others can be so troubled by this disease. In some, the disease will cause strokes, lung problems, leg ulcers etc. If we knew early on who would have it bad, maybe treatments could be given earlier to prevent these problems. But not everyone has it bad, so it is hard to know. ...Read more

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What are the effects of sickle cell anemia?

Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more

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Dr. Jay Park Dr. Park
5 doctors agreed:
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Can sickle cell anemia be fatal?

Dr. Jay Park Dr. Park
5 doctors agreed:

Yes: Individuals with sickle cell anemia are at high risk to develop invasive bacterial infections, e.g., meningitis and bacteremia, especially by pneumococcus. Penicillin prophylaxis, immunization, and prompt medical attention for febrile illness have greatly reduced fatality from serious infection. ...Read more

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Is sickle cell anemia contagious?

No: Sickle cell anemia is not an infection - thus it is not contagious. It is a genetic disease and so, it is hereditary. ...Read more

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Is there a cure for sickle cell anemia?

Is there a cure for sickle cell anemia?

So far only one: At present the only cure for sickle cell disease is a bone marrow transplant. This is being done with greater frequency, and many pediatric transplant centers are participating in a trial with this. The biggest limitation to this is the availability of suitable bone marrow donors. Brothers or sisters are best, but they must be a match and have no more than sickle trait. ...Read more

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Is malaria and sickle cell anemia related?

Sickle cell Trait: can offer some protective value regarding severity of malarial disease. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity..." ...Read more

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How did sickle cell anemia relate to malaria?

How did sickle cell anemia relate to malaria?

Malaria /sickle cell: In a person who has sickle-cell trait, the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.” S ...Read more

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How do you test fetus for sickle cell anemia?

Genetic test Sickle: Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents. ...Read more

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Describe symptoms of sickle cell anemia trait?

Usually none.: Patients with sca trait usually have no symptoms. If they are in an environment where oxygen is low, like high altitude, it is possible to have a pain crisis like sca patients get, but it is quite rare. ...Read more

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What causes sickle cell anemia besides malaria?

Malaria doesnt cause: Sickle cell anemia is a hereditary disease caused by a mutation in the dna coding for hemoglobin. Scientists have long known that sickle cell anemia protects carriers from malaria infections, which could be advantageous in certain parts of the world. Malaria does not cause sickle cell anemia. ...Read more

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What is the cause of sickle cell anemia in fetus?

What is the cause of sickle cell anemia in fetus?

You may be confused.: Fetuses do not suffer from sickle cell anemia in utero because they have a different type of hemoglobin (fetal) that is unaffected even in individuals destined to have sickle cell disease later in life. Affected fetuses come from affected or carrier parents and sickle cell disease is a genetic condition without cure at present. See a genetic counselor to discuss these issues in detail. ...Read more

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What are signs and symptoms of sickle cell anemia?

What are signs and symptoms of sickle cell anemia?

Anemia&pain: Anemia and pain crises ,it could be bone crises or vaso-occlusive sickle crisis.,acute chest syndrome,acute abdominal pain,infection ,and aplastic crisis. ...Read more

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I have sickle cell anemia trait can that affect me?

Usually not: Sickle cell trait is a hemoglobin genotype as and is generally regarded as a benign condition. However, individuals with sickle cell trait may have rare complications that mimic sickle cell disease. ...Read more

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Do i need a operation if I have sickle cell anemia?

Surgery: For sickle cell anemia, you don't need surgery unless a complication of sickle cell affecting your gall bladder or some kind of osteomyelitis requiring surgery. ...Read more

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Is sickle-cell anemia a recessive, sex-linked trait?

Yes and no: Sickle cell disease is recessive; you need to inherit a sickle gene from both parents to get the disease. It is not x-linked, however; if it were it would affect only boys. Boys and girls are equally affected by sickle cell disease. ...Read more

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What is the life expectancy with sickle cell anemia?

close to normal : Scd is many types , the most severe is the ss-disease . Even among patients with ss disease, there are risin the past it was about 4decades. With the improved care, prevention of serious complications by early diagnosis, blood transfusion, exchange for stroke patients and the use of hydroxy urea, life expectancy is becoming close to normal in many patients with scd who are under good medical care. ...Read more

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What are the signs and symptoms of sickle cell anemia?

What are the signs and symptoms of sickle cell anemia?

Sickle Cell Crises: Sickle cell disease can lead to very painful "crises" with severe pain in the bones and joints, in the chest, and in the head. This is caused by changes in the red blood cells, that cause round flexible red cells into stiff, "sickled" cells that cause blockages and blood blood clots. The pain is comes from lack of oxygen to the tissues - like having a heart attack, but in the bones. ...Read more

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Can you tell me how is sickle cell anemia passed down?

Can you tell me how is sickle cell anemia passed down?

Genetic: Sickle cell disease is a genetic condition. You get one set of genes from each of your parents. If they both carry the gene, it is possible for them to pass it to their child. If both parents pass the affected gene, then the child will have sickle cell disease. If one parent passes it to the child, then the child will be a carrier but not be affected by sickle cell disease. ...Read more

Dr. Steven Ginsberg
1,329 doctors shared insights

Anemia (Definition)

A condition marked by a deficiency of red blood cells or hemoglobin in the blood, resulting ...Read more