Doctor insights on:
Sickle Cell Anemia Genetic Disorder
I Don't Think So: I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. ...Read more
A genetic disease is a disease that is caused by a defect in the genetic (dna) material in a gene(s). It can be inherited and mosy pose a risk to other family members and/or to future children. For many genetic diseases there are molecular tests that allow detection of a change(s) called mutations, we can also detect deltions or other changes to the gene's dna that can also result ...Read more
Blood: The genetic defect is in the hemoglobin molecule. ...Read more
Hemoglobinopathy: Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. ...Read more
Yes: A bone marrow transplant can replace the cells responsible for creating sickle cells with cells that produce normal hemoglobin. This is a very difficult and dangerous procedure that can lead to significant complications and death. This is why it is not routinely used to treat sickle cell anemia. Research is ongoing in attempts to have people with sickle cell anemia make normal blood cells. ...Read more
Inherited disease.: Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent. This disease is more common in blacks (people of african heritage). Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other. Those with trait are "carriers" and are often asymptomatic. ...Read moreSee 1 more doctor answer
Yes: It is a defect present from birth, yes. Would i call it a birth defect, no. It is a genetically derived abnormality in the metabolism of hemoglobin that results in sickling of the red cells under some circumstances. As a metabolic disease, it is inherited in a similar fashion to pku or cystic fibrosis. The term birth defect is more appropriate for a kid with malformation of an organ or body part. ...Read more
Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more
If you suffer from a chronic pain disorder such as sickle cell anemia what natural pain relief is there?
Prevent ss crisis: Hydration, a lot of fluids, oxygenation, Folic Acid supplements, treat infection new studies suggest sickle cell patient cannot vasodilate due to low nitric oxide--resveratrol, present in grapes, red wine increase nitric oxide! ---but I am skeptical. ...Read moreSee 1 more doctor answer
Is it possible to be diagnosed with sickle cell anemia at 43? Even without ever experiencing any symptoms of the disease?
Possible, but...: Most people will have symptoms of enough severity to be diagnosed before adulthood. That being said, there is variation in the severity of sickle cell disease, most likely due to a number of other genes that modulate the symptoms. Thus, it probable is quite rare, but there could be that individual with a particular genetic makeup that has minimal disease that goes undiagnosed. ...Read moreSee 1 more doctor answer
Genetics: Sickle cell disease must be inherited from both parents. Sickle cell trait (1 sickle gene, 1 normal gene) is usually asymptomatic. 2 persons with sickle cell trait have a 1/4 chance of having a child with sickle cell disease, but the parents are often unaware that they have anything. ...Read moreSee 2 more doctor answers
From a medical standpoint, "genetic" refers to the potential heritability of various medical conditions. While some conditions are inevitable (at some point in one's life) as a consequence of simple genetic heritability (eg huntington's disease), a large number of medical conditions (including all behaviorial health disorders) are the expressed final pathway of a ...Read more
This is a genetic disorder in which hemoglobin is abnormally made., more common in people of african descent. This abnormality causes red blood cells to become stiff and fall apart. This can cause very specific symptoms: pain, pneumonias, strokes, spleen problems, and many other problems. Some have mild disease, some ...Read more
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