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Doctor insights on: Sickle Cell And Bone Marrow Transplant

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Will a bone marrow transplant cure bone marrow cancer?

Will a bone marrow transplant cure bone marrow cancer?

Yes: However it depends on the type of cancer, if it is in remission or not ,age of the patient and the type of donor. It also depends on the type of transplant, from self or another donor ...Read more

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Dr. Dariush Saghafi
3 doctors shared insights

Transplant (Definition)

In medicine: a transfer from one body or body part to another of an organ (liver, heart, lung, kidney, pancreas bowel) or tissue (hand, face, hair). The immune system fights foreign invaders (like infections) so it will reject transplants from other people (allotransplants) because they look like infections. So transplants usually require drugs to ...Read more


Dr. Liawaty Ho Dr. Ho
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How does aplastic anemia and bone marrow transplant relate?

Dr. Liawaty Ho Dr. Ho
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How does aplastic anemia and bone marrow transplant relate?

Aplastic anemia: Aplastic anemia is a condition where for some unclear reason the bone marrow fails to produce normal blood cells. It could be due to underlying genetic mutation plus environmental -i.e. Drugs, chemical agent, infection, etc. Immunosupressant agent has been used to treat aplastic anemia with some response. Allogeneic bone marrow transplant will be the treatment of choice to cure the disease. ...Read more

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What lethal diseases are treated with bone marrow or stem cell transplants?

What lethal diseases are treated with bone marrow or stem cell transplants?

Many: The main lethal disease treated with stem cell transplants are hematologic malignancies such as leukemia, lymphoma and myeloma. Bone marrow failure (aplastic anemia) is also treated with stem cell transplants. Some life-threatening genetic disease can also be treated with a transplant. ...Read more

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Why are umbilical cord stem cells sometimes uses along with donor cells in an allogeneic bone marrow transplant?

Why are umbilical cord stem cells sometimes uses along with donor cells in an allogeneic bone marrow transplant?

One of the other: Stem cells can be obtained from 3 different sources: from Bone marrow of the Donor, blood of the donor or stem cells from umbilical cord. But we have to give an adequate number(Dose) of stem cells in order to have full protection. So combining them may only be needed because of inadequate number of stem cells from one of the sources ...Read more

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Sickle cell disease bone marrow transplant. Is that working out or not?

Sickle cell disease bone marrow transplant. Is that working out or not?

No clear results.: There is not level 1 evidence to show bone marrow transplant increases survival in patients with sickle cell disease. Although there are several reports with success a systematic randomized trial remains to be done. Bone marrow transplant is a procedure with multiple complications. After the procedure the recipient has to take meds for life. Cost/effective therapy analyses are not present. ...Read more

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Sickle cell disease - is it curable with a bone marrow transplant?

Sickle cell disease - is it curable with a bone marrow transplant?

I do not know.: Most patients with sickle cell diseaes have a very benign manifestation of the diseas (trait) and they can live close to a normal life. E few percentage of this people has severe disease. I do not have experience with bone marrow transplant for sickle cell disease. ...Read more

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What's allogeneic bone marrow transplantation like?

What's allogeneic bone marrow transplantation like?

BMT from a donor: Allogeneic bone marrow transplantation (bmt) uses another person as the source of stem cells (bone marrow) as opposed to autologous bmt which uses the patient's own cells (usually frozen). Syngeneic bmt uses an identical twin for the donor. Allogeneic donors can be relatives (usually siblings) or totally unrelated. For more info on bmt check out: http://marrow.Org/. ...Read more

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How good is the bone marrow transplant for a sickle cell patient?

How good is the bone marrow transplant for a sickle cell patient?

Very!: If a patient with sickle cell disease has a well-matched donor and gets through the transplant procedure safely with good engraftment of the donor bone marrow, they will be converted to normal or sickle trait depending on the donor. ...Read more

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Could stem cells prevent need for a bone marrow transplant?

Could stem cells prevent need for a bone marrow transplant?

NO: Bone marrow transplant is a stem cell procedure. This can be your own bone marrow stem cells, a family member or match for bone marrow or embryonic stem cells. ...Read more

Emily Lu Dr. Lu
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What does a bone marrow transplant do for sickle cell?

Emily Lu Dr. Lu
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What does a bone marrow transplant do for sickle cell?

Replacing RBCs: Sickle cell disease is caused by a person producing faulty red blood cells (rbcs). Since all blood cells are produced in the bone marrow, a bone marrow transplant from a healthy donor should be able to replace the faulty bone marrow with healthy bone marrow that is able to produce normal red blood cells. However, this is not a common treatment so its clinical efficacy is not well-established. ...Read more

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What is a autologous bone marrow transplant?

What is a autologous bone marrow transplant?

The patient is donor: In case of myeloma certain lymphomas in general patients receive chemotherapy , achieve a response and then have stem cells mobilized from their marrow- frozen- patient goes through high doses of chemo to clear the marrow or kill as many tumor cells as possible and then reinfuse cells back. The idea is that high doses of chemotherapy can cause prolong remission or cure ...Read more

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Can someone with type 1 diabetes donate bone marrow or stem cells?

Can someone with type 1 diabetes donate bone marrow or stem cells?

Yes: The potential donor would have to be screened based on the entire health picture. Diabetes is not a contraindication to stem cell donation. ...Read more

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Life expectancy of myeloma patients after autologous stem cell transplant?

Life expectancy of myeloma patients after autologous stem cell transplant?

Myeloma : There are many things that go into predicting life expectancy of somebody with myeloma who has an autologous stem cell transplant. The rough estimate for somebody getting a transplant in first remission is about 6-7 years now. However, this is something your oncologist or transplant doctor can talk to you about with more specific information. ...Read more

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What's involved in allogeneic stem cell transplantation?

What's involved in allogeneic stem cell transplantation?

Donor matching.: This involves two people: the (healthy) donor and the (patient) recipient. Donors must have a tissue (hla) type that matches the recipient. Matching is performed on three or more loci of the hla gene, and a perfect match at these loci is preferred. Even with this, immunosuppression is often needed due to graft vs host disease. ...Read more

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Does stem cell transplantation treat hematologic cancer?

Yes: Stem cell transplant is used to treat leukemias and lymphomas, both are types of hematologist malignancies. ...Read more

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Is aml cancer cured by getting bone marrow transplant?

Yes, but...: Depending on the age of the patient and characteristics of aml, a bone marrow transplantation may be warranted in order to cure a patient. However, in some situations, some subtypes can be cured with chemotherapy alone. ...Read more

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Why avascular necrosis in sickle cell disease involve long bone only?

The ends of : The long bones have the most tenuous blood supply, and thus are at the greatest risk. ...Read more

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Dr. Keith Stockerl-Goldstein
109 doctors shared insights

Bone Marrow Transplant (Definition)

This refers to using chemotherapy and/or radiation therapy to treat patients and then replacing their bone marrow cells with their own stem cells (autologous transplant) or a donors stem cells (allogeneic transplant). Bone marrow transplant generally refers to using bone marrow cells but is often used when using stem cells collected ...Read more


Bone Marrow (Definition)

Bone marrow is the flexible tissue found in the interior of bones. In humans, red blood cells are produced in the heads of long bones, in a process known as hematopoesis. On average, bone marrow constitutes 4% of the total body mass of humans; in an adult weighing 65 kilograms (140 lb), bone marrow accounts for approximately ...Read more