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Doctor insights on: Sickle Cel

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Why would someone need a sickling test?

Why would someone  need a sickling test?

Hemoglobin S: This test determines if a patient has an abnormal form of hemoglobin, that causes sickle cell trait or sickle cell disease. Even people with sickle cell trait can develop complications in circumstanced of low oxygen. ...Read more

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How does the presence of abnormal hb leads to sickling of rbc?

How does the presence of abnormal hb leads to sickling of rbc?

Change in shape: Sickle cell anemia is caused by a single code letter change in the dna. This in turn alters one of the Amino Acids in the hemoglobin protein. Valine sits in the position where glutamic acid should be. The valine makes the hemoglobin molecules stick together, especially under conditions of low oxygen, forming long fibers that distort the shape of the red blood cells, and this brings on an attack. ...Read more

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My 9month old son has low hb even though he seems fine and eats alright. His sickling status is negative. What can be wrong?

My 9month old son has low hb even though he seems fine and eats alright. His sickling status is negative. What   can be wrong?

More info needed: Is patient breast or bottle fed? Has patient been on any vitamin supplement? Any iron supplement? What are the blood counts--are they really anemic or at the low normal for age? Was infant premature? How has pediatrician caring for child advised the family--including introduction of solid foods-- good luck. ...Read more

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How does the sickling of cells cause jaundicr, ulcer and episodes of pains?

How does the sickling of cells cause jaundicr, ulcer and episodes of pains?

Sickle cell pain: The vaso-occlusive crisis is caused by sickle-shaped red blood cells that obstruct capillaries and restrict blood flow to an organ, resulting in ischemia, pain, necrosis and often organ damage. Damage to the liver causes jaundice.The pathogenesis of chronic ulcers in scd is complex: mechanical obstruction, venous incompetence, in situ thrombosis, arteriovenous shunting, decreased local oxygen. ...Read more

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What is sickle cell anemia?

What is sickle cell anemia?

Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capillaries. Blocked circulation causes extreme pain in joints, abdomen, or chest. ...Read more

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Is sickle cell anemia painful?

Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

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Can I have sickle cell anemia?

Can I have sickle cell anemia?

Anyone can...: It would be unlikely that would could reach the age of 46 and not be diagnosed with sickle cell anemia. If you are truly concerned, testing is very easy. ...Read more

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How common is sickle cell anemia?

How common is sickle cell anemia?

Pretty common.: 1 in every 500 african-americans, and 1 in every 900 hispanic americans. ...Read more

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Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Why is sickle cell anemia painful?

Why is sickle cell anemia painful?

Poor circulation: In sickle cell disease red cell stick together and block circulation to extremity and other organ so it cause pain crisis. ...Read more