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Change in shape: Sickle cell anemia is caused by a single code letter change in the dna. This in turn alters one of the Amino Acids in the hemoglobin protein. Valine sits in the position where glutamic acid should be. The valine makes the hemoglobin molecules stick together, especially under conditions of low oxygen, forming long fibers that distort the shape of the red blood cells, and this brings on an attack. ...Read more
My 9month old son has low hb even though he seems fine and eats alright. His sickling status is negative. What can be wrong?
More info needed: Is patient breast or bottle fed? Has patient been on any vitamin supplement? Any iron supplement? What are the blood counts--are they really anemic or at the low normal for age? Was infant premature? How has pediatrician caring for child advised the family--including introduction of solid foods-- good luck. ...Read moreSee 1 more doctor answer
Sickle cell pain: The vaso-occlusive crisis is caused by sickle-shaped red blood cells that obstruct capillaries and restrict blood flow to an organ, resulting in ischemia, pain, necrosis and often organ damage. Damage to the liver causes jaundice.The pathogenesis of chronic ulcers in scd is complex: mechanical obstruction, venous incompetence, in situ thrombosis, arteriovenous shunting, decreased local oxygen. ...Read more