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Doctor insights on: Sickle Cel

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Why would someone need a sickling test?

Why would someone  need a sickling test?

Hemoglobin S: This test determines if a patient has an abnormal form of hemoglobin, that causes sickle cell trait or sickle cell disease. Even people with sickle cell trait can develop complications in circumstanced of low oxygen. ...Read more

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How does the presence of abnormal hb leads to sickling of rbc?

How does the presence of abnormal hb leads to sickling of rbc?

Change in shape: Sickle cell anemia is caused by a single code letter change in the dna. This in turn alters one of the Amino Acids in the hemoglobin protein. Valine sits in the position where glutamic acid should be. The valine makes the hemoglobin molecules stick together, especially under conditions of low oxygen, forming long fibers that distort the shape of the red blood cells, and this brings on an attack. ...Read more

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My 9month old son has low hb even though he seems fine and eats alright. His sickling status is negative. What can be wrong?

My 9month old son has low hb even though he seems fine and eats alright. His sickling status is negative. What   can be wrong?

More info needed: Is patient breast or bottle fed? Has patient been on any vitamin supplement? Any iron supplement? What are the blood counts--are they really anemic or at the low normal for age? Was infant premature? How has pediatrician caring for child advised the family--including introduction of solid foods-- good luck. ...Read more

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How does the sickling of cells cause jaundicr, ulcer and episodes of pains?

How does the sickling of cells cause jaundicr, ulcer and episodes of pains?

Sickle cell pain: The vaso-occlusive crisis is caused by sickle-shaped red blood cells that obstruct capillaries and restrict blood flow to an organ, resulting in ischemia, pain, necrosis and often organ damage. Damage to the liver causes jaundice.The pathogenesis of chronic ulcers in scd is complex: mechanical obstruction, venous incompetence, in situ thrombosis, arteriovenous shunting, decreased local oxygen. ...Read more

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What is sickle cell anemia?

What is sickle cell anemia?

Hereditary: Sickle cell anemia is a hereditary condition where some of the red blood cells become sickle shaped and rigid, and can't get through the smallest capillaries. Blocked circulation causes extreme pain in joints, abdomen, or chest. ...Read more

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Is sickle cell anemia painful?

Is sickle cell anemia painful?

Pain crisis=painful: Sickle cell anemia itself is not painful . However sickle cell anemia can be complicated with crisis episode either in a form of sickle cell pain crisis ( this is painful), or other episode such as acute chest syndrome , stroke etc. ...Read more

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Can I have sickle cell anemia?

Can I have sickle cell anemia?

Anyone can...: It would be unlikely that would could reach the age of 46 and not be diagnosed with sickle cell anemia. If you are truly concerned, testing is very easy. ...Read more

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How common is sickle cell anemia?

How common is sickle cell anemia?

Pretty common.: 1 in every 500 african-americans, and 1 in every 900 hispanic americans. ...Read more

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Is sickle cell anemia hereditary?

Is sickle cell anemia hereditary?

Yes.: it is an autosomal recessive disorder, meaning that both parents must be carriers of the mutation. If they are, the chance of each child being affected is 1 in 4. ...Read more

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Why is sickle cell anemia painful?

Why is sickle cell anemia painful?

Poor circulation: In sickle cell disease red cell stick together and block circulation to extremity and other organ so it cause pain crisis. ...Read more

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How is sickle cell anemia detected?

Blood test: Every newborn baby undergoes "newborn screening" test before they are released from hospital. Most of abnormal hemoglobins, e.g. Hemoglobin s in sickle cell disease, are detected. ...Read more

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How dangerous is sickle cell anemia?

More info needed: Patients with sickle cell anemia have greater tendency for severe anemia and infection. Usually children have more difficulties. Sometimes frequent transfusion is needed to assist in crises, or to suppress sickle hemoglobin and decrease sickling issues which can be very painful. Hydroxyurea is used to help symptoms and to increase fetal hemoglobin, vaccinations, and antibiotics help. See MD. ...Read more

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What is the trend in sickle cell anemia?

Who will have it bad: The trend currently is trying to find out why some people have very little problems and others can be so troubled by this disease. In some, the disease will cause strokes, lung problems, leg ulcers etc. If we knew early on who would have it bad, maybe treatments could be given earlier to prevent these problems. But not everyone has it bad, so it is hard to know. ...Read more

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Is sickle cell anemia a severe condition?

Depends: It depends on the type of sickle cell disease a patient has, and how many attacks they get in a year and how severe those attacks are. ...Read more

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What to tell me about sickle cell anemia?

What to tell me about sickle cell anemia?

See below: Sickle cell anemia occurs when 2 abnormal hemoglobin genes are present and a person's body produces sickle cell hemoglobin exclusively. 1 sickle cell gene and a normal gene produce sickle trait, which has no symptoms. Other abnormal hemoglobin genes can combine with a sickle cell gene and produce other types of anemia. There are several other genetic hemoglobin abnormalities. ...Read more

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What are the tests for sickle cell anemia?

What are the tests for sickle cell anemia?

Hb electrophoresis: CBC and hemoglobin electrophoresis have to be done -at least- to make a diagnosis of sickle cell anemia. ...Read more

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What is the symptoms of sickle cell anemia?

Anemia, pain, crises: The most frequent presenting signs/symptoms of sickle cell include anemia and typical sickle cell crises which include pain crises (severe pain in arms, legs, shoulders, back), acute chest crisis (shortness of breath, cough, fever, lung infiltrate), dactylitis (pain toes/fingers usually as a toddler) and others. Most patients that have sickle cell trait are completely asymptomatic. ...Read more

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What are the effects of sickle cell anemia?

Many.: Basically, sickle cell disease causes disturbance of the blood vessels, typically smaller vessels. Over time, this can cause many problems. Painful episodes, eye problems, lung problems (similar to pneumonia), strokes, decreased spleen function (which can cause severe infections), kidney problems, and o ther problems. Sickle cell disease is not the same in all people. Some have milder symptoms. ...Read more

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What kind of disorder is sickle cell anemia?

What kind of disorder is sickle cell anemia?

Genetic: With ss disease a genetic mutation changes the gene sequencing needed for normal hemoglobin production.The alteration changes the way the hemoglobin handles the oxygen molecule as it carries it in the blood.The blood cell then becomes distorted in the small capillaries and the spleen.The cell breaks down rapidly and or remains trapped.Anemia is a chronic problem. ...Read more

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What is the 'reverse' of sickle cell anemia?

What is the 'reverse' of sickle cell anemia?

None: Sicle cell anemia is an inherent disorder of the red blood cell. The reverse woould be normal blood cells. ...Read more