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Sickle Beta Plus Thalassemia
Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount.See 1 more doctor answer
Blood test: Sickle Beta cell Thalassemia is an inherited disorder and new born screening is available and should be done. This disorder is due to decreased synthesis or absence of beta globulin chains. It may manifest in infancy and early childhood and may cause serious medical problems which need to be treatedSee 1 more doctor answer
Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms.See 1 more doctor answer
Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. Two hgbs alleles causes sickle cell dz. But you can inherit one hgbs and one beta thal allele (so called sickle-beta thal). Dz severity depends on beta globin expression from thal allele.
I'm 33 with sickle cell beta+thalassemia I'm having sharp pain in right ear n jaw n throat. My neck hurtscslso all on my right side. What's wrong? Tp
More information?: For short duration pain, Sickle crisis may be but this pain sounds like many other problems. While deep pain may be difficult to pinpoint for the patient, she can have all of the diseases other people have. TMJ arthritis, supperative otitis media, lesions of middle ear, TM, upper pharynx. Many people with Sickle beta plus thal do not know it and never have seizures, others have them more oftenSee 2 more doctor answers
SICKLE CELL AFFECTS: With sickle cell the spleen can be destroyed by the crisis episodes.See 1 more doctor answer
I have a hemoglobinopathy (not sickle cell or thalassemia). At what point is medication considered for my anemia?
Symptoms or severe: Depends on specific etiology, as treatments may vary significantly. Generally aggressive tx like transfusions are avoided except in emergencies, but other tx will be considered if there are sxs (like dizziness, weakness, shortness of breath) or if the blood level is low enough to cause other issues (e.g., high-output heart failure). Diet may be important as well in minimizing or avoiding meds.See 3 more doctor answers
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B (0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B (+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount.
Yes!: Sickle cell and beta thalassemia both affect the same part of hemoglobin. If you inherit a sickle gene from one parent and a thalassemia gene from the other, you have sickle/b-thalassemia. The severity depends on whether the thal gene works a little (b+) or not at all (b0). Sickle cell and Alpha thalassemia are inherited independently; you can inherit both from the same parent or one from each.
Yes: The mutations causing sickle cell disease and beta thalassemias both occur in the beta hemoglobin gene. There are many people who have one copy of beta hemoglobin with the sickle cell mutation, and the other copy carries a beta-thalassemia mutation. Depending on the combination, symptoms can vary. For a nice summary, see: http://www. Cdc. Gov/ncbddd/sicklecell/facts. Html.See 1 more doctor answer
Yes: Both sickle cell and beta thalassemia affect the same gene; each person has 2 copies of that gene. If you have a sickle mutation on one gene and a thal mutation on the other you have sickle/beta-thal, which behaves much like sickle cell anemia. You can also inherit sickle cell anemia and Alpha thalassemia together.See 1 more doctor answer
If a person has a little higher than normal hgb f result, but no symptoms, does that confirm thalassemia b minor? No sickle cell in the family.
No.: Beta thalassemia would be suggested by an elevated HGB a2. There are many different genetic abnormalities that cause thalassemia. Some may increase HGB f, though this is not the norm. Also, thalassemia causes small red blood cells and an related red blood cell count with variable degrees of anemia due to low hemoglobin.See 1 more doctor answer
Yes and no: If you have the sickle cell mutation on one beta hemoglobin gene and a thalassemia mutation on the second gene, then you have sickle cell beta thalassemia - this is not a trait but a disease. The severity of the disease is dependent upon the size/ location of the thalassemia mutation.See 2 more doctor answers
It's an inherited: Disorder caused by mutation in the 6th codon of the beta globin chain, one of two globins that constitute hemoglobin-a. People who are homozygous (2 copies) for the mutation have sickle cell disease. People who are heterozygous for the mutation (1 copy) have sickle cell trait. Some pts inherit one hgbs allele and one "thalassemia" allele (aka sickle-beta thal), that's similar to sickle cell dz.See 1 more doctor answer
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