Doctor insights on:
Sickle Beta Plus Thalassemia
Not if just 1 trait: Having either beta thalassemia trait or sickle cell trait is a mild condition and should not cause symptoms to the point of making a person frequently ill nor shortening life expectancy. Having beta thalassemia major or sickle cell disease, or both sickle cell trait and beta thalassemia trait, usually causes severe enough chronic disease symptoms to shorten lifespan an uncertain amount. ...Read more
Blood test: Sickle Beta cell Thalassemia is an inherited disorder and new born screening is available and should be done. This disorder is due to decreased synthesis or absence of beta globulin chains. It may manifest in infancy and early childhood and may cause serious medical problems which need to be treated ...Read more
Got both mutations: A person has sickle cell beta thalassemia if he inherited one gene mutation for sickle cell anemia, and also inherited one gene mutation for beta thalassemia. He can have symptoms of sickle cell disease, unlike patients with only sickle cell trait who are generally without symptoms. ...Read more
Beta thalassemia: Is a quantitative deficiency of beta globin, caused by alterations in regulatory elements governing beta globin expression. The mutation that causes sickle cell anemia is a qualitative abnormality of beta globin. Two hgbs alleles causes sickle cell dz. But you can inherit one hgbs and one beta thal allele (so called sickle-beta thal). Dz severity depends on beta globin expression from thal allele. ...Read more
I'm 33 with sickle cell beta+thalassemia I'm having sharp pain in right ear n jaw n throat. My neck hurtscslso all on my right side. What's wrong?tp
More information?: For short duration pain, Sickle crisis may be but this pain sounds like many other problems. While deep pain may be difficult to pinpoint for the patient, she can have all the diseases other people have. TMJ arthritis, supperative otitis media, lesions of middle ear, TM, upper pharynx. Many people with Sickle beta plus thal do not know it and never have seizures, others have them more often ...Read more
SICKLE CELL AFFECTS : With sickle cell the spleen can be destroyed by the crisis episodes. ...Read more
I have a hemoglobinopathy (not sickle cell or thalassemia). At what point is medication considered for my anemia?
Symptoms or severe: Depends on specific etiology, as treatments may vary significantly. Generally aggressive tx like transfusions are avoided except in emergencies, but other tx will be considered if there are sxs (like dizziness, weakness, shortness of breath) or if the blood level is low enough to cause other issues (e.g., high-output heart failure). Diet may be important as well in minimizing or avoiding meds. ...Read more
Most less severe: Most are less severe in sickle cell thalassemia, but depends. HbS/B(0)thal: similar to HbSS in severity maybe slightly less severe. HbS/B(+)thal: has 60% HbSS and 30% HbA, thus less severe than HbSS (sickle cell alone). HbS/A-thal: less severe than HbSS due to decreased HbSS amount. ...Read more
Yes!: Sickle cell and beta thalassemia both affect the same part of hemoglobin. If you inherit a sickle gene from one parent and a thalassemia gene from the other, you have sickle/b-thalassemia. The severity depends on whether the thal gene works a little (b+) or not at all (b0). Sickle cell and Alpha thalassemia are inherited independently; you can inherit both from the same parent or one from each. ...Read more
Yes: The mutations causing sickle cell disease and beta thalassemias both occur in the beta hemoglobin gene. There are many people who have one copy of beta hemoglobin with the sickle cell mutation, and the other copy carries a beta-thalassemia mutation. Depending on the combination, symptoms can vary. For a nice summary, see: http://www.Cdc. Gov/ncbddd/sicklecell/facts. Html. ...Read more
Yes: Both sickle cell and beta thalassemia affect the same gene; each person has 2 copies of that gene. If you have a sickle mutation on one gene and a thal mutation on the other you have sickle/beta-thal, which behaves much like sickle cell anemia. You can also inherit sickle cell anemia and Alpha thalassemia together. ...Read more
If a person has a little higher than normal hgb f result, but no symptoms, does that confirm thalassemia b minor? No sickle cell in the family.
No. : Beta thalassemia would be suggested by an elevated HGB a2. There are many genetic abnormalities that cause thalassemia. Some may increase HGB f, though this is not the norm. Also, thalassemia causes small red blood cells and a related red blood cell count with variable degrees of anemia due to low hemoglobin. ...Read more
Yes and no: If you have the sickle cell mutation on one beta hemoglobin gene and a thalassemia mutation on the second gene, then you have sickle cell beta thalassemia — this is not a trait but a disease. The severity of the disease is dependent upon the size/ location of the thalassemia mutation. ...Read more
It's an inherited: Disorder caused by mutation in the 6th codon of the beta globin chain, one of two globins that constitute hemoglobin-a. People who are homozygous (2 copies) for the mutation have sickle cell disease. People who are heterozygous for the mutation (1 copy) have sickle cell trait. Some (pts) inherit one hgbs allele and one "thalassemia" allele (aka sickle-beta thal), that's similar to sickle cell dz. ...Read more
Depends on type...: There are different types of beta thalassemia (minor, intermedia, or major for example) that have much different impacts on a patient's health. Treatment can range from nothing (minor) to requiring frequent blood transfusions, iron chelation therapy or even a bone marrow transplant (major). A hematologist can help with the management of all types. ...Read more
Yes: Thalassemia is one of the most common gene mutations in the world. Overall, an estimated 20-25 million people are carriers (1/300) (about 1/1000 in low-risk peoples, and about 1/30 in high-risk peoples). Low risk: japanese, korean, n. European caucasians, native canadians, native americans. High risk: mediterranean, middle eastern, south asian, south-east Asian (western pacific rim), caribbean. ...Read more
No: I am going to assume you have beta thalassemia minor. This is a minor abnormality that makes you trivially anemic and makes your blood cells look a little odd. If you marry someone else who has this, each of your children had 1/4 chance of having thal major, which is a horrible illness. Heads up. Best wishes. ...Read more
What kind?: Beta thal minor shouldn't be a problem. If you have beta thal major and are asking this question, you should be congratulated on your excellent response to treatment and I hope that you get what you want -- but don't be disapponted if you're asked to remain a civilian. ...Read more
Major or minor?: Beta thal minor is a non-problem; the rate of red cell production is somewhat higher so get plenty of Folic Acid in your diet or supplement. Beta thal major is a very serious illness requiring lifelong close management by a physician; again, the need for Folic Acid and a generally nutritious diet is worth remembering but there's no magical food remedy. Good luck. ...Read more
How to know if someone had thalassemia @ beta thalassemia? What criteria if they had it is dangerous?
Why is it that alpha and beta -thalassemias result in more clinically severe diseases than other types of thalassemia?
Used for blood cells: Alpha globulin (made by the Alpha genes) and beta globulin (made by the beta genes) are the 2 globulin molecules needed to make normal adult hemoglobin (the red stuff in normal red blood cells). Mutations that prevent Alpha and beta globulin production will cause severe symptoms, but other mutations may not be as noticeable if the proteins the other genes make are not as crucial to life. ...Read more
I have beta thalassemia and I have hemoglibin d, my fiancee has minor beta thalassemia, is there any problem for our child in future?
I would: Suggest you better directly ask a hematologist or a geneticist they are in position to give you best answer... ...Read more
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