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Doctor insights on: Should I See A Rheumatologist If I Have Elevated Complement Levels

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Should I see a rheumatologist if I have elevated complement levels?

Should I see a rheumatologist if I have elevated complement levels?

Don t think so: Complement is an acute phase reactantant , having high complement levels only means there is a reaction , probably inflammatory . If the diagnosis is ulcerative colitis , but you don t have arthritis youndont need to see the rheumatologist for high complement leves. ...Read more

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Dr. Daniel Lebowitz
21 doctors shared insights

Complement Levels (Definition)

Total complement activity (CH50, CH100) looks at the overall activity of the complement system. Typically, other tests that are more specific for the suspected disease are performed first. C3 and C4 are the most commonly measured complement components. A complement test may be used to monitor patients with an autoimmune disorder and to see if treatment for their condition is working. For example, patients with active lupus erythematosus may have lower-than-normal levels of the complement ...Read more


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What do low complement levels indicate is going on?

What do low complement levels indicate is going on?

Some things: To consider: 1) autoimmunity (particularly sle) 2) immunodeficiency 3) blood dyscrasia or cancer. ...Read more

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What would having low complement levels indicate?

What would having low complement levels indicate?

Low complement: Low levels of complement are seen in persons with complement deficiency who are prone to recurrent infections as well as in certain autoimmune conditions, inherited angioedema conditions, and hives associated with vasculitis (inflammed blood vessels). These can all be serious. Collection of blood to measure complement is tricky and needs to be done right or low level could occur. ...Read more

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I've never head of complement levels, what do they mean when they are low?

I've never head of complement levels, what do they mean when they are low?

Complement: Complement are proteins in the blood that are part of the immune system. Individuals with very low or absent complement are prone to infections such as recurrent neisseria meningitis. If the blood test isn't put on ice right after it is drawn, then a low level could result that is incorrect. ...Read more

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I have vesico-ureteric reflux and acute hypertension, why would complement levels be an investigation?

I have vesico-ureteric reflux and acute hypertension, why would complement levels be an investigation?

See Below: Most likely they are looking to see if your body is attacking your kidneys by activating complement proteins in the kidney tissue. If there is complement deposition there then the explanation for your hypertension may be injury to your kidneys from this. ...Read more

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Can low complement levels cause lichen planus ( armpit) and tinea versicolor?

Can low complement levels cause lichen planus ( armpit) and tinea versicolor?

Yes and no: Tinea versicolor is a fungal infection. It may present due to a decrease in the immune system (low complement). Lichen planus is an autoimmune disorder of unknown origin. Various autoimmune illnesses are associated with increased incidence in lichen planus. Secondary raynaud's disease also has been linked with some autoinmune disorders such as lupus, rheumatoid arthritis and sjogren's syndrome. ...Read more

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Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP

Can you have lupus with completely normal bloodwork? ANA, ENA neg, Complement levels normal, CBC normal. ESR of 2 and normal CRP

ANA negative lupus: There is an entity called ANA negative lupus. Please visit this site for diagnostic criteria for SLE. From what you have described, it is unlikely that you have lupus. http://www.lupusresearchinstitute.org/lupus-facts/lupus-diagnosis ...Read more

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Have borderline low C3 and C4 complement levels and low 1:80 titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Have borderline low C3 and C4 complement levels and low 1:80  titre positive ANA speckled. With symptoms relating to sle and sjorgrens - atypical ?

Atypical for what?: Rheumatic disease generally requires a cluster of suggestive symptoms which is supported by lab studies. I do not know your symptoms, but your labs are not particularly suggestive of anything. ...Read more

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Would it be appropriate to see a hematologist regarding elevated aptt and promethin levels that were done for lupus? Or should I see a rheumatologist

See below: Sounds as if you may have a lupus anticoagulant based on what you are stating which can be seen in the setting of lupus. If have not had a major clotting episode or stroke, you may not need to see the hematologist but your rheumatologist or your primary can make that call. ...Read more

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Hi I recently had testing do to a miscarriage. My protein c level was elevated at a value of 202. Also my anti thrombin 3 was elevated value 126. What if any underlying conditions will cause elevation. I have been told to follow up with a rheumatologist.

Hi I recently had testing do to a miscarriage. My protein c level was elevated at a value of 202. Also my anti thrombin 3 was elevated value 126. What if any underlying conditions will cause elevation. I have been told to follow up with a rheumatologist.

Autoimmune disorders: There are numerous autoimmune disorders that can contribute to increased risk of miscarriage. In addition there may be abnormal clotting disorders related to protein C & thrombin. A thorough evaluation with a specialist in autoimmune disorders is recommended to avoid a recurrence. Best of luck. ...Read more

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Should i see a rheumatologist about ulnar nerve subluxation?

No: You are probably better served by seeing an orthopedist if you suspect ulnar nerve damage. ...Read more

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How often should I see a rheumatologist again, if my antinuclear antibody is positive, but i'm not sick?

How often should I see a rheumatologist again, if my antinuclear antibody is positive, but i'm not sick?

It depends: If the rheumatologist has told you nothing else is showing up, you may not need to see the specialist again for a long time, or ever. Lots of people have a positive ANA and it doesn't always mean there is a disease state. If it's very high, you are at higher risk of getting something, but if low, your primary care can recheck it annually as long as you continue to feel well. Ask the rheum. ...Read more

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Considering visco supplementation injections or steroid injection for arthritic knees. Should I see a rheumatologist or an orthopaedic for this?

Considering visco supplementation injections or steroid injection for arthritic knees. Should I see a rheumatologist or an orthopaedic for this?

ORS: Either can inject your painful arthritic knee. My preference would be an experienced board certified ORS, however, as he or she can treat you medically, and if your pain continues and it is indicated, surgically. Best of Luck! ...Read more

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Should I see a rheumatologist? I have really swelling in my hands that comes and goes. Recently I have a bump on my one knuckle that burns and itches.

Should I see a rheumatologist? I have really swelling in my hands that comes and goes. Recently I have a bump on my one knuckle that burns and itches.

Angioedema: Description sounds like angioedema that typically occurs in association with hives (in some cases). Let your primary care physician know about this, or see an Allergist or Dermatologist. This is sometimes caused by an environmental trigger. Treatment starts with a long-acting antihistamine. ...Read more

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How often should a child with jra/jia see her rheumatologist?

How often should a child with jra/jia see her rheumatologist?

It depends: If there is active disease and medication doses are being adjusted, it may need to be as frequent as every 2-4 weeks. If things are stable, visits can often be spaced out to every few months. ...Read more

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Complement (Definition)

The complement system is an important effector mechanism of both humoral and innate immunity. Its functions are to promote phagocytosis of microbes, to stimulate inflammation, and to induce lysis of these organisms. The system is highly complex and comprised of over 50 effector and regulatory molecules. It is activated via one of three pathways: antibody, lectin, or by ...Read more