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Doctor insights on: Severe Dysesthesia

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L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse. Could I have glutamate metabolism disorder or glutamate receptor antibodies?

L-glutamic acid gives me severe dysesthesias. D-glutamic acid is worse.  Could I have glutamate metabolism disorder or glutamate receptor antibodies?

Possibly but...: Good question without an easy answer. Glutamate is an "excitotoxin" that is not healthy for anyone but some people are more sensitive to it than others. There are a variety of uncommon glutamate metabolism disorders but you do not need to have one of these to be adversely affected by glutamate. Dysesthesias are not a known symptom of antibodies to glutamate receptors. See my comments:. ...Read more

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What is dysesthesia?

Dysesthesia: is an uncomfortable abnormal sensation.

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What is the difference between the medical terms "paresthesias" and "dysesthesias"?

What is the difference between the medical terms "paresthesias" and "dysesthesias"?

Itching versus pain: Paresthesias refer to abnormal sensation "numbness and tingling" which can be annoying. Dysesthesias are a more intense version of the same sensation which you would call painful. The sensations run on the same nerve endings, again one is just more intense than the other. ...Read more

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Could antibodies to the nmda-like receptors in the epidermis cause dysesthesias?

Could antibodies to the nmda-like receptors in the epidermis cause dysesthesias?

Dysesthesias: There is some data about nmda-receptor antibodies leading to encephalitis and inflammatory issues, but this would need to be discussed with your neurologist. ...Read more

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Why does spinal toxoplasmosis cause dysesthesias and mental illness?

Why does spinal toxoplasmosis cause dysesthesias and mental illness?

Connexion: Spine is connected to brain. Even though the lesion is in spine, it can extend its menifestations to extend the whole central nervous system. ...Read more

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What is facial dysesthesia or neuralgia?!! Is that a problem for a 20 year old female?!

What is facial dysesthesia or neuralgia?!! Is that a problem for a 20 year old female?!

Men AND women: A dysesthesia is an alteration in any of the senses of the body especially that of touch. Commonly it is an unpleasant sensation produced by a normal stimulus. Neuralgia, however, is clearly a painful and BRIEF sensation which can be brought on by touch or other stimuli. INVESTIGATING IT'S CAUSE WHEN DISCOVERED SHOULD BE DONE IN MY OPINION in both men and women. ...Read more

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What do the paresthesias/dysesthesias associated with RLS usually feel like? Are they uncomfortable or are they truly painful?

What do the paresthesias/dysesthesias associated with RLS usually feel like? Are they uncomfortable or are they truly painful?

Could be both: They have been described as both. If they are really significantly painful there may be something else going on like circulation issue or neuropathy. ...Read more

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For approx 8 weeks i've had a "burning" type of sensation under skin through entire body. No visible hives. Could this be dysesthesia or ms-related?

For approx 8 weeks i've had a "burning" type of sensation under skin through entire body. No visible hives. Could this be dysesthesia or ms-related?

Possible answer: Has anyone discussed a diffuse small fibre neuropathy? This can cause diffuse burning pain, and may be associated with a number of conditions. To diagnose, you will need an EMG study, and perhaps, a 3 site skin punch biopsy. Additional blood studies are decided based on this approach. May wind up having a vitamin deficiency. Find an experienced neurologist in this regard. Doubt ms. ...Read more

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Why would you seek to find which of the two types of pain a patient feel (when it comes to numbness; paresthesia or dysesthesia? would diagnosis diffe

Why would you seek to find which of the two types of pain a patient feel (when it comes to numbness; paresthesia or dysesthesia? would diagnosis diffe

Dysesthesia: The most common paresthesia is "pins and needles," when a foot or hand "falls asleep." Paresthesia has no permanent ill effects, relatively mild, and can be from mild nerve compression. DYSesthesia is a sign of nerve damage, a painfully abnormal feeling like diabetic neuropathy. Medicine like Gabapentin or Pregabalin, Duloxetine or Trazadone can help with the pain but do not stop the paresthesias. ...Read more

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