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Doctor insights on: Serzone Serotonin Antagonist And Reuptake Inhibitor

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How do "serotonin antagonist and reuptake inhibitors" ssris work?

How do "serotonin antagonist and reuptake inhibitors" ssris work?

Still unclear: We know what they do--block reuptake at the neuron. But, why that helps with depression and anxiety, among other disorders, remains unclear. Especially puzzling is why it typically takes weeks or even months to produce the effect, suggesting strongly that it is not the direct effect that causes improvement but some change that induces downstream. ...Read more

Dr. Zahid Niazi
26 doctors shared insights

Nefazodone (Definition)

Nefazadone (brand serzone) is an antidepressant closely related to trazodone. This is a potent 5-ht2a antagonist. Due to low affinities to other neurotransmitters it has fewer side effects. Unfortunately it was discontinued in many countries due to acute liver failure. Bristol-myers-squibb discontinued it in 2004. There are generic forms ...Read more


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What are alternatives to serotonin reuptake inhibitors (ssris)?

What are alternatives to serotonin reuptake inhibitors (ssris)?

Several: Although ssris have been by far the most popular class of antidepressants for many years, there are several other options that focus on different systems. Wellbutrin is thought to work through dopamine; remeron, cymbalta, effexor, & others, also affect norepinephrin; and deprenyl and others are MAO inhibitors. Each has pluses and minues and may work when ssris don't. ...Read more

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What does "selective" mean in selective serotonin reuptake inhibitor?

What does "selective" mean in selective serotonin reuptake inhibitor?

Just one type: "selective" in this case refers to the fact that the previous generation of antidepressants, the tricyclics, worked on all 3 of the neurotransmitters in the brain thought to be involved in depression in varying degrees; serotonin, norepinephrine, and dopamine. Prozac, and the other ssris act almost entirely on serotonin. ...Read more

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What is the definition or description of: selective serotonin reuptake inhibitor?

SSRI's: Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders. ...Read more

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Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

Which is more effective? Tricyclics or SSRIs (selective serotonin reuptake inhibitors)?

TCA/SSRI: Both are, depending on what they are prescribed for. The difference is in tolerability & side-effects. ...Read more

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Can some one tell me the best serotonin reuptake inhibitor to use for sadness?

Can some one tell me the best serotonin reuptake inhibitor to use for sadness?

Like perfume: There is no best without considering personal context. Also, there may be quite a few that will work for any given patient. Your insurance company will prefer you start with lowest price product. Like perfume, if you like the effect, then it is best for you. Potential for drug-drug interaction can also be a consideration, but that is a complex analysis that you need to figure out with your doctor. ...Read more

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Are mild auditory hallucinations linked to withdrawal from mood disorder medications, serotonin reuptake inhibitors in particular?

Are mild auditory hallucinations linked to withdrawal from mood disorder medications, serotonin reuptake inhibitors in particular?

Only in Effexor: Other more serious symptoms have also been reported with venlafaxine discontinuation and include auditory and visual hallucinations, illusions, prolonged delusions , tinnitus as well as other isolated but significant symptoms such as palinopsia, persistent and recurrent visual images. Not reported in cymbalta.J can acad child adolesc psychiatry. 2011 february; 20(1): 60–67. ...Read more

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Are selective serotonin reuptake inhibitors safe to use if you have high blood pressure?

Are selective serotonin reuptake inhibitors safe to use if you have high blood pressure?

Yes, BUT: Ssri's can be used, but certain medications used in managing hypertension can produce serious drug-drug interactions. Make sure all of your doctors know all of your medications, even the seemingly innocuous ones, and notify all of your doctors about any new medications added or deleted, including over the counter ones you may buy on your own! ...Read more

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How does lyrica work? Is it similiar to narcotic pain medicine? Or similiar to tramadol as norepinephrine and serotonin reuptake inhibitor?

Lyrica: Dear pika89800 lyrica enhances gaba in the brain and suppresses pain at a cortical level, pain has 3 main levels, local, spinal and brain (cortex), it is non narcotic, it is an antiseizure medication and can sometimes help both pain and anxiety the answer is purely for educational purposes, please contact your md. ...Read more

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Serotonin (Definition)

Serotonin is a chemical derived from the Amino Acid tryptophan and acts as a neurotransmitter (communicating ...Read more


Dr. John Landi
21 doctors shared insights

Serzone (Definition)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of ...Read more