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Doctor insights on: Serzone

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Dr. Gregory Moneta
22 doctors shared insights

Serzone (Overview)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of antidepressant drug (psychiatric drug).


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Is serzone still on the market?

Is serzone still on the market?

In the US, no.: Serzone, name brand, was withdrawn from the market in the us and canada in 2007. This was due to reports of potential liver damage. However, the generic form, Nefazodone is available in places. ...Read more

Dr. Gregory Moneta
22 doctors shared insights

Serzone (Overview)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of antidepressant drug (psychiatric drug).


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When do doctors choose to prescribe serzone (nefazodone)?

When do doctors choose to prescribe serzone (nefazodone)?

Good drug!: Serzone is related to trazadone, an earlier ad that put people to sleep. It is an effective antidepressant with low toxicity. The antidepressant action of Nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. As effective as newer ssris. ...Read more

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Can serzone b combined with cymbalta (duloxetine)?

Can serzone b combined with cymbalta (duloxetine)?

Theoretically : Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile. Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome. ...Read more

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How about serzone and its side effects?

How about serzone and its side effects?

Not in market: Was a great drug had issues with liver problem we have not used in a while has been pulled off the market according to my knowledge unless my peers want to update me. ...Read more

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What about long-term use of nefazodone, does a person get less and less benefit from it over time?

What about long-term use of nefazodone, does a person get less and less benefit from it over time?

Not really: Usually if you respond to a dose of an antidepressant, you maintain the response so long as you stay on the same dose. There is a "poop-out" occurance but it is uncommon and probably not related to the medication but to the disease. One example is people with bipolar disorder usually do not maintain their response because of medication-disease interaction. ...Read more

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Is serzone still on the market?

In the US, no.: Serzone, name brand, was withdrawn from the market in the us and canada in 2007. This was due to reports of potential liver damage. However, the generic form, Nefazodone is available in places. ...Read more

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Is serzone still available...And if not what happened?

Is serzone still available...And if not what happened?

Serzone: Serzone was withdrawn from the market in 2004 due to reports of liver failure leading to transplantation and death. However, its generic, nefazodone, is still available, . ...Read more

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How about serzone and its side effects?

Not in market: Was a great drug had issues with liver problem we have not used in a while has been pulled off the market according to my knowledge unless my peers want to update me. ...Read more

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True that serzone has no sexual side effects?

True that serzone has no sexual side effects?

Generally much less!: One possibly important way in which Nefazodone differs from other ssris is that while use of ssris is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. ...Read more

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Can serzone b combined with cymbalta (duloxetine)?

Theoretically : Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile. Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome. ...Read more

See 2 more doctor answers
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13
When do doctors choose to prescribe serzone (nefazodone)?

Good drug!: Serzone is related to trazadone, an earlier ad that put people to sleep. It is an effective antidepressant with low toxicity. The antidepressant action of Nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. As effective as newer ssris. ...Read more

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Help plz! Can serzone be combined with cymbalta (duloxetine)?

Help plz! Can serzone be combined with cymbalta (duloxetine)?

Yes: There is a small rare risk of serotonin syndrome whenever two antidepressants are combined. It is not something that should prevent you from taking the two meds together. ...Read more

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Is serzone or Prozac (fluoxetine) is better?

Is serzone or Prozac (fluoxetine) is better?

They r different: Serzone isn't available was associated with liver priblems. ...Read more

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What is the definition or description of: nefazodone?

What is the definition or description of: nefazodone?

An Antidepressant: Nefazadone (brand serzone) is an antidepressant closely related to trazodone. This is a potent 5-ht2a antagonist. Due to low affinities to other neurotransmitters it has fewer side effects. Unfortunately it was discontinued in many countries due to acute liver failure. Bristol-myers-squibb discontinued it in 2004. There are generic forms available in the us. ...Read more

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What happens when a person suddenly stops taking nefazodone?

What happens when a person suddenly stops taking nefazodone?

Depends on dose: Usually nothing happens. There maybe some mild withdrawal sx but more than likely not much but maybe poor sleep. The main problem is stopping a med and having relapse of the anxiety and depression that it is treating. If you are only getting a partial response, sudden stopping can be worse than if the depression and anxiety are all better. If stopping discuss with your prescriber to prepare. ...Read more

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What about long-term use of nefazodone, does a person get less and less benefit from it over time?

Not really: Usually if you respond to a dose of an antidepressant, you maintain the response so long as you stay on the same dose. There is a "poop-out" occurance but it is uncommon and probably not related to the medication but to the disease. One example is people with bipolar disorder usually do not maintain their response because of medication-disease interaction. ...Read more

Dr. Colin McCannel
27 doctors shared insights

Nefazodone (Definition)

Nefazadone (brand serzone) is an antidepressant closely related to trazodone. This is a potent 5-ht2a antagonist. Due to low affinities to other neurotransmitters it has fewer side effects. Unfortunately it was discontinued in many countries due to acute liver failure. Bristol-myers-squibb discontinued it in 2004. There are generic forms ...Read more