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Doctor insights on: Serzone

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Dr. Milton Alvis Jr
22 doctors shared insights

Serzone (Overview)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of antidepressant drug (psychiatric drug).


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Is serzone still on the market?

Is serzone still on the market?

In the US, no.: Serzone, name brand, was withdrawn from the market in the us and canada in 2007. This was due to reports of potential liver damage. However, the generic form, Nefazodone is available in places. ...Read more

Dr. Milton Alvis Jr
22 doctors shared insights

Serzone (Overview)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of antidepressant drug (psychiatric drug).


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When do doctors choose to prescribe serzone (nefazodone)?

When do doctors choose to prescribe serzone (nefazodone)?

Good drug!: Serzone is related to trazadone, an earlier ad that put people to sleep. It is an effective antidepressant with low toxicity. The antidepressant action of Nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. As effective as newer ssris. ...Read more

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Can serzone b combined with cymbalta (duloxetine)?

Can serzone b combined with cymbalta (duloxetine)?

Theoretically : Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile. Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome. ...Read more

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How about serzone and its side effects?

How about serzone and its side effects?

Not in market: Was a great drug had issues with liver problem we have not used in a while has been pulled off the market according to my knowledge unless my peers want to update me. ...Read more

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What about long-term use of nefazodone, does a person get less and less benefit from it over time?

What about long-term use of nefazodone, does a person get less and less benefit from it over time?

Not really: Usually if you respond to a dose of an antidepressant, you maintain the response so long as you stay on the same dose. There is a "poop-out" occurance but it is uncommon and probably not related to the medication but to the disease. One example is people with bipolar disorder usually do not maintain their response because of medication-disease interaction. ...Read more

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Is serzone still on the market?

In the US, no.: Serzone, name brand, was withdrawn from the market in the us and canada in 2007. This was due to reports of potential liver damage. However, the generic form, Nefazodone is available in places. ...Read more

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Is serzone still available...And if not what happened?

Is serzone still available...And if not what happened?

Serzone: Serzone was withdrawn from the market in 2004 due to reports of liver failure leading to transplantation and death. However, its generic, nefazodone, is still available, . ...Read more

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How about serzone and its side effects?

Not in market: Was a great drug had issues with liver problem we have not used in a while has been pulled off the market according to my knowledge unless my peers want to update me. ...Read more

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True that serzone has no sexual side effects?

True that serzone has no sexual side effects?

Generally much less!: One possibly important way in which Nefazodone differs from other ssris is that while use of ssris is often associated with sexual dysfunction and sleep disturbances, these side-effects have been reported infrequently in people taking nefazodone. ...Read more

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Can serzone b combined with cymbalta (duloxetine)?

Theoretically : Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile. Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome. ...Read more

See 2 more doctor answers
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When do doctors choose to prescribe serzone (nefazodone)?

Good drug!: Serzone is related to trazadone, an earlier ad that put people to sleep. It is an effective antidepressant with low toxicity. The antidepressant action of Nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. As effective as newer ssris. ...Read more

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Help plz! Can serzone be combined with cymbalta (duloxetine)?

Help plz! Can serzone be combined with cymbalta (duloxetine)?

Yes: There is a small rare risk of serotonin syndrome whenever two antidepressants are combined. It is not something that should prevent you from taking the two meds together. ...Read more

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Is serzone or Prozac (fluoxetine) is better?

Is serzone or Prozac (fluoxetine) is better?

They r different: Serzone isn't available was associated with liver priblems. ...Read more

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What is the definition or description of: nefazodone?

What is the definition or description of: nefazodone?

An Antidepressant: Nefazadone (brand serzone) is an antidepressant closely related to trazodone. This is a potent 5-ht2a antagonist. Due to low affinities to other neurotransmitters it has fewer side effects. Unfortunately it was discontinued in many countries due to acute liver failure. Bristol-myers-squibb discontinued it in 2004. There are generic forms available in the us. ...Read more

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What happens when a person suddenly stops taking nefazodone?

What happens when a person suddenly stops taking nefazodone?

Depends on dose: Usually nothing happens. There maybe some mild withdrawal sx but more than likely not much but maybe poor sleep. The main problem is stopping a med and having relapse of the anxiety and depression that it is treating. If you are only getting a partial response, sudden stopping can be worse than if the depression and anxiety are all better. If stopping discuss with your prescriber to prepare. ...Read more

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What about long-term use of nefazodone, does a person get less and less benefit from it over time?

Not really: Usually if you respond to a dose of an antidepressant, you maintain the response so long as you stay on the same dose. There is a "poop-out" occurance but it is uncommon and probably not related to the medication but to the disease. One example is people with bipolar disorder usually do not maintain their response because of medication-disease interaction. ...Read more

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Can nefazodone and cymbalta (duloxetine) be taken together?

Can nefazodone and cymbalta (duloxetine) be taken together?

Possibly: Both of these medications increase serotonin. If used together they should be monitored closely. ...Read more

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Is nefazodone dangerous? My rx'er declined a trial due to the potential liver risks, but I'm not convinced given it's rarity.

Is nefazodone dangerous?  My rx'er declined a trial due to the potential liver risks, but I'm not convinced given it's rarity.

Side FX: Liver toxicity occurs in about 0.1-1% of nefazodone users. Headache and sleepiness occur in 28-36%, and nausea in 23% of users. There are many less common side effects. It may not be good to use in combination with other medicines- that may be a reason not to use it too. ...Read more

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If you had an allergy to nefazodone, would you also have allergy to trazodone?

If you had an allergy to nefazodone, would you also have allergy to trazodone?

You might: It is not uncommon to have allergic reactions (ar's) to both Nefazodone and trazodone. It is easy to confuse ar's with medication side effects (se's). Common ar's are skin rashes, breathing problems, and chills/fever. Common se's for these medications include blurred vision, dry mouth, sedation, and GI problems. Check with your md to determine if your reactions were true ar's or se's! ...Read more

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Is nefazodone or Prozac (fluoxetine) better to relax you and help you get some sleep?

Is nefazodone or Prozac (fluoxetine) better to relax you and help you get some sleep?

Serzone/Prozac: Serzone is used to be prescribed for depression & insomnia. Prozac (fluoxetine) is unlikely to be sedating. Best to discuss with your doctor the sleep hygiene techniques or google that for more info. ...Read more

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Some people have an allergy to nefazodone. Would they also have a similar allegy to trazodone?

Some people have an allergy to nefazodone.  Would they also have a similar allegy to trazodone?

Not necessarily: They are different compounds with differing effects. However, anyone with an allergy to one med is at higher risk to be allergic to another. Going on and off meds repeatedly may sensitive you to a medication. ...Read more

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What happens if someone suddenly stops taking prescribed anti-depressant medication such as nefazodone?

What happens if someone suddenly stops taking prescribed anti-depressant medication such as nefazodone?

Sometimes nothing.: There is a prevalent theory that individuals put on an antidepressant should try and be weened off twice after a three, then six month trial. If negative vfeelings relapse, they should be kept on the antidepressant. However, sudden cessation of any antidepressant without medical supervision can lead to rebound depression. ...Read more

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I really want to try a Zoloft/nefazodone combo. Is it safe? If so, what doses? I am also on 50 mg Trazdone. Thank you!!!

I really want to try a Zoloft/nefazodone combo.  Is it safe? If so, what doses?  I am also on 50  mg Trazdone.  Thank you!!!

Risk when combined: Zoloft, (sertraline) Nefazodone, and trazodone increase serotonin which may lead to rare serotonin syndrome which requires immediate medical attention when it occurs. Work closely with prescriber and report all side effects. Combo of medication and psychotherapy and life skills is best. Best regards for relief. ...Read more

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My doctor ordered nefazodone for depression. Is this strange for a first line drug?

My doctor ordered nefazodone for depression. Is this strange for a first line drug?

Not really: Prescriptions for Nefazodone decreased several years ago due to concerns over liver toxicity. It is an effective antidepressant with a very low degree of sexual side effects. ...Read more

Dr. Ana Adelstein
27 doctors shared insights

Nefazodone (Definition)

Nefazadone (brand serzone) is an antidepressant closely related to trazodone. This is a potent 5-ht2a antagonist. Due to low affinities to other neurotransmitters it has fewer side effects. Unfortunately it was discontinued in many countries due to acute liver failure. Bristol-myers-squibb discontinued it in 2004. There are generic forms ...Read more