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Doctor insights on: Serzone

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Dr. Al Hegab
22 doctors shared insights

Serzone (Overview)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of antidepressant drug (psychiatric drug).


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Is serzone still on the market?

Is serzone still on the market?

In the US, no.: Serzone, name brand, was withdrawn from the market in the us and canada in 2007. This was due to reports of potential liver damage. However, the generic form, Nefazodone is available in places. ...Read more

Dr. Al Hegab
22 doctors shared insights

Serzone (Overview)

Serzone is a serotonin antagonist and reuptake inhibitor which is a kind of antidepressant drug (psychiatric drug).


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When do doctors choose to prescribe serzone (nefazodone)?

When do doctors choose to prescribe serzone (nefazodone)?

Good drug!: Serzone is related to trazadone, an earlier ad that put people to sleep. It is an effective antidepressant with low toxicity. The antidepressant action of Nefazodone is thought to be dependent on its ability to block postsynaptic serotonin type-2 receptors and inhibit presynaptic serotonin reuptake. Nefazodone also blocks norepinephrine reuptake. As effective as newer ssris. ...Read more

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Can serzone b combined with cymbalta (duloxetine)?

Can serzone b combined with cymbalta (duloxetine)?

Theoretically : Serzone (nefazodone) is an antidepressant quite popular when introduced due to a favorable side effect profile. Post- marketing research showed that it can cause liver failure at a rate higher than the rate in the general population. Bristol-myers squibb discontinued it, but it is still available in generic form. Combining it with Cymbalta (duloxetine) may increase risk of serotonin syndrome. ...Read more

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How about serzone and its side effects?

How about serzone and its side effects?

Not in market: Was a great drug had issues with liver problem we have not used in a while has been pulled off the market according to my knowledge unless my peers want to update me. ...Read more

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What about long-term use of nefazodone, does a person get less and less benefit from it over time?

What about long-term use of nefazodone, does a person get less and less benefit from it over time?

Not really: Usually if you respond to a dose of an antidepressant, you maintain the response so long as you stay on the same dose. There is a "poop-out" occurance but it is uncommon and probably not related to the medication but to the disease. One example is people with bipolar disorder usually do not maintain their response because of medication-disease interaction. ...Read more

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Is serzone still on the market?

In the US, no.: Serzone, name brand, was withdrawn from the market in the us and canada in 2007. This was due to reports of potential liver damage. However, the generic form, Nefazodone is available in places. ...Read more

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Is serzone still available...And if not what happened?

Is serzone still available...And if not what happened?

Serzone: Serzone was withdrawn from the market in 2004 due to reports of liver failure leading to transplantation and death. However, its generic, nefazodone, is still available, . ...Read more

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How about serzone and its side effects?

Not in market: Was a great drug had issues with liver problem we have not used in a while has been pulled off the market according to my knowledge unless my peers want to update me. ...Read more

Dr. Steven Griggs
27 doctors shared insights

Nefazodone (Definition)

Nefazadone (brand serzone) is an antidepressant closely related to trazodone. This is a potent 5-ht2a antagonist. Due to low affinities to other neurotransmitters it has fewer side effects. Unfortunately it was discontinued in many countries due to acute liver failure. Bristol-myers-squibb discontinued it in 2004. There are generic forms ...Read more