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Doctor insights on: Serum Sickness Like Syndrome

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What's serum sickness?

What's serum sickness?

Systemic allergic: Systemic allergic response in which antibody-antigen reaction in the blood stream causes systemic problems. Read more

Dr. James Chapman
16 Doctors shared insights

Serum Sickness (Definition)

Serum sickness is a type of hypersensitivity reaction (type iii immune reaction) that occurs when the immune system develops antibodies to a foreign protein. The antibody and the foreign protein combine to form an immune complex (ic) that can settle in areas of the body such as the joints or the kidney. The ic can damage these areas and cause arthralgias ...Read more


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Can serum sickness be cured?

Can serum sickness be cured?

Yes: The most common treatment for serum sickness is discontinuation of the offending drug, combined with the use of both antihistamines and glucocorticoids. Withdrawal of the drug by itself is usually sufficient treatment for patients with mild symptoms. Fever and joint pains resolve within 48 hours. To prevent recurrence, the culprit drug should be avoided in the future, if possible. Read more

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How can I treat serum sickness?

How can I treat serum sickness?

Avoidance: Not much can be done specifically to treat serum sickness, other than avoiding the antigen that caused it in the first place. If there is significant joint or other inflammation, steroids can help reduce the symptoms while waiting for the reaction to go away. Read more

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Can you die from serum sickness?

Can you die from serum sickness?

Unfortunately...Yes: Serum sickness got it's name from reactions after treatments with high doses of horse serum given for treatments snake bites or tetanus. Antibiotics can also cause this. The persons antibodies clump with the foreign serum proteins. These clumps (immune complexes) can clog small blood vessels in the skin, mucous membranes, joints, kidneys and intestines. Fulminant severe reaction can be fatal. Read more

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Has anyone else had serum sickness?

Has anyone else had serum sickness?

Serum Sickness: Serum sickness is a reaction that is similar to an allergy. The immune system reacts to medications that contain injected proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that contains antibodies given to a person to help protect them against germs or poisonous substances. Read more

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Are the symptoms of serum sickness bad?

Are the symptoms of serum sickness bad?

Can be: Serum sickness usually causes fever, lymph node enlargement, arthritis, muscle pain, weakness, renal disease, severity of the disease would determine the severity of symptoms. Read more

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Has anyone ever heard of "serum sickness"?

Has anyone ever heard of "serum sickness"?

Systemic allergic: Systemic allergic response in which antibody-antigen reaction in the blood stream causes systemic problems. Read more

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Can I die from serum sickness if I ignore it?

Can I die from serum sickness if I ignore it?

Yes: Serum sickness can lead to organ damage and vascular collapse if the offending agent is not stopped. Normally however it is a self-limited syndrome which resolves after the offending agent is removed. Read more

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Are some people more prone to getting serum sickness?

Are some people more prone to getting serum sickness?

Serum sickness: Classic serum sickness is caused by administration of a protein antigen from a non-human species. There have been some case reports implicating the drugs Rituximab and Infliximab (used to treat chron's disease and rheumatoid arthritis). Rarely, repeated blood transfusions, insect stings, and mosquito bites can cause serum sickness-type reactions. Read more

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What is the definition or description of: serum sickness?

What is the definition or description of: serum sickness?

Hypersensitivity: Serum sickness is a type of hypersensitivity reaction (type iii immune reaction) that occurs when the immune system develops antibodies to a foreign protein. The antibody and the foreign protein combine to form an immune complex (ic) that can settle in areas of the body such as the joints or the kidney. The ic can damage these areas and cause arthralgias and glomerulonephritis for example. Read more

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What are the differences between arthrus reaction and serum sickness?

What are the differences between arthrus reaction and serum sickness?

Similar: Both are type III hypersensitivity or allergic reactions that occur from antibody antigen complexes. The arthus reaction typically occurs after an injection into the skin and the reaction is vasculitis at the site. Serum sickness commonly follows an oral ingestion (like a drug) and symptoms are more general with fever, rash, joint aches, lymph node swelling and sometimes protein in the urine. Read more

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Can remicaide cause serum sickness and if so, how can I test for sensitivity to it?

Yes, and more: Remicade (infliximab), as any foreign protein, can cause a number of adverse effects. It is "humanized", meaning part of it comes from cells that originally were of mice. Our body can produce antibodies to Remicade in our blood that can be measured in specialty laboratories. Even if a patient develops such antibodies, there are ways to help tolerate Remicade or use alternative medications. Read more

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My 3 yr old had sever serum sickness in june. Her entire body swelled / joints had red marks. She still complains about pain. Is this common?

My 3 yr old had sever serum sickness in june. Her entire body swelled / joints had red marks. She still complains about pain. Is this common?

Yes-possible: Serum sickness is a self-limited disorder, ; symptoms resolve with time as the immune complexes are cleared from the system. The use of antihistamines, nonsteroidal anti-inflammatory drugs (nsaids), and corticosteroids helps to ameliorate the symptoms. Symptoms like your comment about pain can last 1-2 weeks. Nsaids are given to relieve this pain. See an allergist/immunologist if still concerned. Read more

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4yr old son has serum sickness, hives are getting worse and ankles are swollen, ive been giving him ben. And mot. Is there something else for itching?

4yr old son has serum sickness, hives are getting worse and ankles are swollen, ive been giving him ben. And mot. Is there something else for itching?

Doctor evaluation: If your son was diagnosed with serum sickness, and has lupus, his doctor is best to judge what he needs more, sometimes steroids might be added, but that's the doctor's judgement Read more

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I've taken three dosages of bactrum ds can I still end up having serum sickness? My left hand hurts right on the top. For no apparent reason. That's why I was wondering

I've taken three dosages of bactrum ds can I still end up having serum sickness? My left hand hurts right on the top. For no apparent reason. That's why I was wondering

NO: Serum sickness develops with sulfa drugs after a period (usually long term) of treatment!
FURTHERMORE serum sickness joint pain is SYMMETRICAL. ...not just with L hand/wrist!

Hope this helps!
Dr Z Read more

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What negative results in paraneoplastic serum panel mean? What the like hood to have the neurology syndrome with negative results?

What negative results in paraneoplastic serum panel mean? What the like hood to have the neurology syndrome with negative results?

Based on H&P: A para neoplastic syndrome is based on history and exam. Do not base the absence of a para neoplastic syndrome on a negative serum panel. I rarely get the panel because you treat the person and the disease not the test. Hope this helps. Read more

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Is it possible to have serum sickness without presence of fever? (3 yr old, onset 12 days after starting amoxicillin, itchy rash and swollen joints)

Is it possible to have serum sickness without presence of fever? (3 yr old, onset 12 days after starting amoxicillin, itchy rash and swollen joints)

Usually not possible: fever is present in almost all cases, could there be exceptions, yes, but also it could be something else other than serum sickness, hard to make a diagnosis or suggest treatment on this platform, you need to see her doctor or a doctor who can guide you well, ? Order some lab tests and imaging studies after careful history and physical exam, good luck Read more

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Does a serum prolactin level test show your serotonin level 2 can I get serotonin syndrome from 10mg a nite of amitriptyline when it not 1st time used?

Does a serum prolactin level test show your serotonin level 2 can I get serotonin syndrome from 10mg a nite of amitriptyline when it not 1st time used?

Serum prolactin test: Measures prolactin, not serotonin.

Serotonin syndrome usually is caused by a combination of medicines, not just one.

Please see this link for very helpful information including a list of drugs to compare to those you are taking.

http://www. Mayoclinic. Com/health/serotonin-syndrome/ds00860. Read more

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Serum (Definition)

Serum is the component of blood that does not contain cells or clotting factors. It does contain electrolytes an ...Read more