Doctor insights on:
Serum Ionized Calcium
Why r my calcium levels normal, while my ionized calcium levels are high? I have bone pain, fatigue, kidney stones. I don't know pth level, or vit. D.
Most calcium in the blood is bound to a molecule called albumin, and this calcium fluctuates depending on the level of albumin. The rest is "ionized" calcium and this is freely available for biologic processes. Labs used to only be able to measure total calcium - calcium bound to Albumin + ionized. Now we can measure ionized calcium and not be mislead that calcium is low ...Read more
Ionized Calcium 4.65, PTH 133, Calcium 10.3, Vitamin D 7, Phosphorus 4.9, recurrent Kidney stones. Thyroid lobe, two parathyroids removed in 2004.
Uncertain: These test results don't add up to a straight forward answer. However, I would be concerned about the possibility of recurrent primary hyperparathyroidism. You should take Vit D to eliminate Vit D deficiency as a cause for high PTH levels. Once this is done, if you still have high PTH with high calcium levels, you have recurrent primary HPTH and will need surgery again. ...Read more
For someone with serum calcium and ionized calcium both at the 95% cutoff level (highest normal), are vitamin D injections of safe?
Not advised: Vitamin D helps the gut absorb calcium into the bloodstream. If your calcium level is already relatively high, extra vitamin d would not be a good idea. You might want to check your parathyroid hormone level to find out why your calcium level is high. ...Read moreSee 1 more doctor answer
Albumin deficiency: Total calcium is attached to albumin, an important protein in the blood. Your serum calcium may be erroneously normal if your ionized calcium is significantly elevated, look at Albumin level and also repeat the calcium tests to make sure no mistake. May need to look at mg, phos, and intact pth. ...Read moreSee 1 more doctor answer
A low vitamin d=10.1mg/ml, calcium serum =10.9 mg/dl.Pth=31pg/ml and ionized calcium serum=5.1mg/dl is it normal?Doctor gave me 50, 000 units of vit
Don't think so.: Each lab report should have a reference range of "normal" values. The reference range changes from lab to lab because each lab runs their test differently. Automated (machine) analyzers tend to have less variability, and in most of those machines, an ionized calcium of 1.1 to1.2 Is about in the middle of the "reference range". ...Read more
Hypocalcemia: You should see your physician. Hypocalcemia has many causes, lab error, Vitamin D deficiency, hypoparathyroidism, pseudohypoparathyroidism, kidney disease or end stage renal disease causing vitamin D deficiency, critical illness, drugs, post-parathyroidectomy, malabsorption,etc. Signs to watch for are muscle spasms , parenthesias, numbness around the mouth. http://tinyurl.com/p22ebrx ...Read more
Depends on context: More information is needed, especially in regards to a correction factor against the serum albumin in hypocalcemia. Ionized calcium is a good measure too, but again, context is necessary. Please see your doctor to help you with clinical context of laboratory values, because the values are not really significant until they are applied to your clinical situation. ...Read moreSee 2 more doctor answers
What's the difference between low ionized calcium and low calcium? Which one is the true measure of hypocalcemia?
Both: If you can measure (rarely done), calculate (complicated formula) or estimate (calcium minus albumin), you will get the ionized calcium. About half of the calcium in the blood is ionized and this is the active form. In real-life, this means that a lot of sick people with low albumin also have low total calcium but needn't worry as the physiologic ionized calcium is what's regulated. ...Read more
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