Doctor insights on:
Serum Glutamate Pyruvate Transaminase
Can autoantibodies against glutamine synthetase and/or glutamate dehydrogenase cause glutamate metabolism disorders?
Still searching: Glutamine synthase is part of the glutamine synthetase family. Ammonia incorporation in animals occurs through the actions of glutamate dehydrogenase and glutamine synthase. Glutamate plays the central role in mammalian nitrogen flow, serving as both a nitrogen donor and nitrogen acceptor. I am unble to find references in my search so far as to autoantibodies to these but see comment. ...Read more
Yes.: In the most common situation it is inherited in an x-linked pattern, affecting hemizygous males (with one x chromosome) and heterozygous females (two x chromosomes, one with mutation). Less commonly it is inherited in an autosomal recessive pattern, in which a mutation must be provided by both the mother and the father of the affected person. ...Read moreSee 1 more doctor answer
Inorgan.Phosphate0.77, serum total protein63, serum globulin14, all slightly low. Norm. Calcium &albumin.Tsh9.25, known hypothyroidism. Further tests?
Blood results: alt/sgpt serum level=40 iu/l, serum alkaline phosphatase=43 iu/l, serum bilirubin level=2 umol/l, serum urea level=2.3 mmol/l. Normal?
Normal: It is very important to know why these were drawn in what sounds to be an otherwise healthy 19 year old. Did you expect to find something wrong? ...Read more
Enzymes: Pyruvate dehydrogenase complex is a complex of three enzymes in the mitichondria that change the Amino Acid pyruvate into the molecule acetyl-coa by a process called pyruvate decarboxylation. Acetyl-coa is used in the citric acid cycle to make energy for cells the complex links the metabolic pathway that breaks down glucose (elemental sugar) to the citric acid cycle. ...Read more
Plasma Vitamin D <4.2 ng/mL
Serum Vitamin B12 -197
Serun Alkaline Phosphatase-356
Need Vits D3 and B12: You are severely deficient in Vitamins D3 and B12. I recommend 10,000 IU of Vit D3 per day, and 1,000 mcg methylcobalamin each day. Your D3 levels should be 60-70 ng/dl. ...Read more
Max 3.2 ng: Sensitivity of prostatic acid phosphatase is very low 39% of the prostatic carcinomas acid phosphatase level was below the upper limit of normal fixed at 3.2ng. Specificity is high t 96% of cases with abnormally high ri acid phosphatase levels, the diagnosis was adenocarcinoma. In the absence of bone metastases high acid phosphatase level is predictive of lymph node involvement in 90%. ...Read more
Pyruvate: Please go online to Wikipedia and look for pyruvate dehydrogenase deficiency. Not easy reading but important. If that is what you have it can be controlled to some extent. Take your time reading the article(s) and then discuss with your doctor. ...Read more
Could asupplement with aminoacids, vitamins(l-carnitine, l-tartaric acid, potassium chloride, l-leucine, isoleucine, valine, nicotinic)cause damage on brain?
Increased aldolase, complement c3/c4 serum, sed rate, c-react. Protein, beta globulin, monocytes, bun/creatin low mcv-mch, vit d-possible causes?
Complicated: When i was doing clinical medicine, these were collectively sort of the flags for sarcoid disease but I am not saying that's the case here. This is because sarcoid is a diagnosis of exclusion so the advice is to rule out other diseases with additional diagnostic tests which can be done by a primary care physician or rheumatologist. ...Read more
Don't treat labs: Omega-3's have been a massive disappointment in most areas when subjected to scientific testing. Most important is finding WHY these liver tests are up. If it's chronic hepatitis B or C, hemochromatosis, Wilson's, or autoimmune hepatitis, you're going to die if you're not diagnosed & Rx'd. If this is non-alcoholic steatohepatitis, nothing will help as much as getting aerobically fit. ...Read more
Diagnosis needed: Serum creatinine is affected by protein intake, gender, age, race, muscular build, and renal function. A rising creatinine is always of concern. "normal" on lab tests is generally less than 1.2 mg/dl. Renal function can be estimated with a more complex formula or measured with a 24 h urine collection. See your internist for further evaluation. ...Read more
I like to know what albumin serum 4.4 calcium serum 9.8 creatinine serum and posassium serum 3.8 protein total serum 6.9 and sodium serum 142
What would cause an intolerance to glutamic acid? Gad autoantibodies? Gad deficiency? Glutamate receptor autoantibodies(anti-nmda, anti-ampa)?
None of the above.: Msg - ubiquitous Amino Acid and major excitatory neurotransmitter in brain. Studied extensively. Does not cause allergy or intolerance except at high dose and only then in susceptible persons when given in large doses without food. See fda, j. Nutrition, food chem and toxicology, etc. ...Read moreSee 1 more doctor answer
I did a liver profile test :
alkaline phosphatase 47.1 u/l
aspartate aminotransferase (sgot )39 u/l alanine transaminase (sgpt)53.7 u/l?
Get a follow-up: Expect these to be repeated iwth you off alcohol and any meds you don't truly need. There may be a hepatitis, iron overload, wilson's ; maybe autoimmue hepatitis workup in your future. You also list B12 ; vitamin d deficiency; i trust these are being managed ; the causes identified. ...Read more
Sir which high enzyme levels indicate significant liver damage due to alcohol? GGT levels or SGPT or SGOT levels..
SGOT / SGPT: These are better markers for damage. SGPT 38, SGOT 28 are not concerning though they're higher than most young men's. Some men run a high GGT even if they don't drink and this shouldn't be taken as proving anything. If you're drinking daily, this might be a good time to cut way back -- who really needs to be doing this? ...Read more
Total protein 8.3, serum albumin 4.2 , serum globulin 3.8, albumin globulin ratio 1.2.. Is this abnormal?
Abnormal labs: It would be helpful that for the labs mentioned above. If you. Can find the normal range or reference range and list it than our answer can be more educated and helpful. The reference range does vary from one lab to another. ...Read more
Protein Total Serum 8.7
Globulin Serum 4.20
Albumin/ Globulin Ratio 1.07
Urea/ CreatinineRatio 18.54
rest normal . Any worries here ?
Need more info.: All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, there is no immediate concern, however, your globulin level may be higher than normal and you should discuss it with the doctor who ordered the tests. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex. ...Read more
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